Frederick Korley, MD, PhD

Frederick K. Korley
Associate Chair of Research
Massey TBI Grand Challenge Scientific Director-Weil Institute
Professor of Emergency Medicine
Medical School
[email protected]
Available to mentor
Frederick Korley, MD, PhD
Frederick K. Korley
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Korley is a Professor and the Associate Chair for Research in Emergency Medicine at the University of Michigan. He is also the scientific director of the Massey TBI Grand Challenge, sponsored by the Weil Institute at the University of Michigan. This challenge distributes up to $750,000 annually to investigators with high-risk and high-reward ideas for developing novel diagnostics and therapeutics for traumatic brain injury (TBI).
    He completed his medical degree and residency training in emergency medicine at Northwestern University, where he served as chief resident. Subsequently, he completed a doctoral degree in clinical investigation at the Johns Hopkins University Bloomberg School of Public Health and was elected to Phi Beta Kappa. He was formerly on faculty at Johns Hopkins University where he was the inaugural recipient of the Robert E. Meyerhoff Endowed Professorship.
    Dr. Korley has conducted pioneering work in uncovering and quantifying gaps in emergency department evaluation and management of traumatic brain injury (TBI) and has developed novel diagnostic and therapeutic approaches to bridge these gaps. He is a PI of several NIH and Department of Defense-funded studies that aim to develop novel therapies for TBI and to use blood-based biomarkers to monitor response to therapy. He holds four patents for panels of brain‑injury biomarkers and the methods used to measure them at the bedside. Dr. Korley’s research has been published as first-author manuscripts in high-impact journals such as NEJM, JAMA, JAMA Cardiology, Journal of the American College of Cardiology, and Lancet Neurology. He is the recipient of the 2021 SAEM Mid-Career Investigator Award. He is an elected member of the American Society for Clinical Investigators and the National Academy of Medicine.

    Qualifications

    • KL2 Clinical Research Scholar
      Johns Hopkins Institute for Clinical and Translational Research, Baltimore, United States
      2010 - 2012
      Postdoctoral Research
    • Emergency Medicine
      Northwestern University Feinberg School of Medicine, Department of Emergency Medicine, Chicago, United States
      2003 - 2007
      Residency
    • Emergency Medicine
      Northwestern University Feinberg School of Medicine, Emergency Medicine, Chicago, United States
      2006 - 2007
      Chief Resident

    Center Memberships

    • Center Member
      University of Michigan Injury Prevention Center
    • Center Member
      Weil Institute for Critical Care Research
    • Center Member
      Center for Computational Medicine and Bioinformatics

    Research Overview

    • Development of Novel Diagnostics and Therapeutics for Traumatic Brain Injury
    • Building an Emergency Medicine Learning Health System

    Recent Publications

    See All Publications
    • Journal Article
      Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study.
      Yue JK, Fu AY, Jain S, Puccio AM, Eagle SR, Korley FK, van Essen TA, Samanta R, Li LM, Roberts CJ, Caldwell DJ, Elguindy MM, Vassar MJ, Belton PJ, Bhattacharyay S, Nelson LD, Tracey JX, Etemad LL, Gotthardt CJ, Satris GG, Wang MB, Demos C, Sigal GB, Amorim E, Madhok DY, Radabaugh HL, Ferguson AR, Markowitz AJ, Robertson CS, Valadka AB, Mukherjee P, Yuh EL, McCrea MA, Hinson HE, Schneider ALC, Sun X, Okonkwo DO, Kobeissy FH, Manley GT, Diaz-Arrastia R, Wang KKW, TRACK-TBI Investigators . J Neuroinflammation, 2026 May 28; DOI:10.1186/s12974-026-03891-3
      PMID: 42210282
    • Journal Article
      Early Autonomic Dysfunction After Severe Traumatic Brain Injury: A Brief Report.
      Wongsripuemtet P, Dong K, Vavilala MS, Miller JB, Minic Z, Ohnuma T, Laskowitz D, Goldstein B, Korley F, Meurer W, Kaakati A, Chaikittisilipa N, Kiatchai T, Wang Z, Hu X, Krishnamoorthy V. Anesth Analg, 2026 Mar 30; DOI:10.1213/ANE.0000000000008019
      PMID: 41910955
    • Journal Article
      Continuous Ketone Monitoring in Diabetic Ketoacidosis: Prospective Multicenter Method-Comparison and Feasibility Study.
      Haas NL, Korley FK, Schneider RM, Mamillapalli SL, Hepworth E, Cranford JA, Lin YK, Griffey RT. Diabetes Technol Ther, 2026 Mar 9; 15209156261428034 DOI:10.1177/15209156261428034
      PMID: 41800718
    • Journal Article
      Abstract WP370: Potential of Plasma GFAP to Rule Out Minor Stroke in Low-Risk Emergency Department Patients
      Mamer L, Korley F, Zahuranec D, Scott P. Stroke, 2026 Jan 31; 57 (Suppl_1): DOI:10.1161/str.57.suppl_1.wp370
    • Journal Article
      A Bayesian model with seasonal effects for predicting accrual in clinical trials: Application to HOBIT and BOOST-3 trials for severe traumatic brain injury
      Rahman MM, Saif MSI, Beall J, Martin RL, Rockswold GL, Barsan WG, Korley FK, Silbergleit R, Stevenson V, Gajewski B. Contemporary Clinical Trials Communications, 2025 Dec 1; 48: DOI:10.1016/j.conctc.2025.101586
    • Journal Article
      Longitudinal pain intensity and interference symptomatology in mild traumatic brain injury: a TRACK-TBI study.
      Gotthardt CJ, Barber JK, Eagle SR, van Essen TA, Nelson LD, Fu AY, Satris GG, Vreeburg RJG, Tracey JX, Etemad LL, Wong JC, Elguindy MM, Belton PJ, Madhok DY, Korley FK, Ferguson AR, Torres-Espin A, Duhaime A-C, Halabi C, Huang MC, Tarapore PE, DiGiorgio AM, Valadka AB, Robertson CS, Mukherjee P, Yuh EL, Puccio AM, Okonkwo DO, Giacino JT, McCrea MA, Temkin NR, Manley GT, Yue JK, TRACK-TBI Investigators . Pain, 2025 Nov 19; DOI:10.1097/j.pain.0000000000003869
      PMID: 41734261
    • Journal Article
      Bayesian enrollment modeling for several emergency medicine clinical trials.
      Beall J, Yeatts SD, Silbergleit R, Shutter L, Korley F, Gajewski B. Trials, 2025 Nov 10; 26 (1): 483 DOI:10.1186/s13063-025-08748-3
      PMID: PMC12599014
    • Proceeding / Abstract / Poster
      Abstract Sat203: Rapid UCH-L1 and GFAP Brain Injury Biomarker Detection in Out-of-Hospital Cardiac Arrest: A Swine Model and Prehospital Feasibility Study
      Moll K, Sharpe Z, Harding L, Gomez C, Duckett Z, Greer N, Tiba M, Gherasim C, Korley F, Rees P, Price J, Hsu C. Circulation, 2025 Nov 6; 152 (Suppl_3): asat203 - asat203. DOI:10.1161/circ.152.suppl_3.sat203

    Featured News & Stories

    Fred Korley speaks at a podium with a screen that reads "Emergency Medicine Funding rankings: 1. Vanderbilt 2. Yale 3. U-M"
    Department News

    Barsan Day Highlights Emergency Medicine Research and Innovation

    From artificial intelligence and cardiac arrest innovation to national clinical trials and education research, the University of Michigan Department of Emergency Medicine’s annual Barsan Research Day showcased the research shaping the future of emergency care.
    Dr. Frederick Korley welcomes attendees to the 2026 Massey TBI Grand Challenge kickoff. On the projector screen behind him is an image of Joyce and Don Massey of the Massey Family Foundation, whose gift led to the establishment of the TBI Grand Challenge as well as other TBI focused programs at the Weil Institute..
    Research News

    University of Michigan innovators unite to transform care and outcomes in TBI

    Highlights from the 11th Massey Traumatic Brain Injury Grand Challenge kickoff event.
    In the foreground, a patient wearing a continuous glucose monitor on their left arm listens to a clinician, who is seated across from them and is holding a tablet.
    Research News

    Weil team’s publication the second most downloaded in critical care-focused medical journal

    The study’s authors speculate that the recognition by CHEST Critical Care could indicate a rising interest in critical care research led by emergency departments.
    Dee E. Fenner, M.D., Lisa Hope Harris, M.D., Ph.D., and Frederick Kofi Korley, M.D., Ph.D., new elected members of the National Academy of Medicine
    News Release

    Three U-M faculty elected to National Academy of Medicine

    Dee E. Fenner, M.D., Lisa Hope Harris, M.D., Ph.D., and Frederick Kofi Korley, M.D., Ph.D., are the latest University of Michigan Medical School faculty to join the National Academy of Medicine
    MRI of brain
    News Release

    U-M researchers receive $13 million to transform traumatic brain injury care

    University of Michigan has received two grants to change how traumatic brain injury is treated.
    Clinician looking at brain MRI images
    Research News

    Weil research teams land major Department of Defense grants to reshape brain injury care

    Research teams led by Dr. J. Brian Fowlkes and Dr. Frederick Korley have received nearly $8.5 million in funding from the Department of Defense for their novel approaches to addressing challenges in the diagnosis, monitoring and management of traumatic brain injury (TBI).