Frederick Korley, MD, PhD
Associate Chair of Research
Professor of Emergency Medicine
[email protected]

Available to mentor

Frederick Korley, MD, PhD
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Frederick Korley, M.D., Ph.D. is a Professor of Emergency Medicine at the University of Michigan. He completed his medical degree and residency training in emergency medicine at the Northwestern University where he served as chief resident. He subsequently completed a doctoral degree in clinical investigation at the Johns Hopkins University Bloomberg School of Public Health and was elected to Phi Beta Kappa. He was formerly on faculty at Johns Hopkins University as the inaugural recipient of Robert E. Meyerhoff Endowed Professorship.

    His research work is focused on the development of novel diagnostics and therapeutics for traumatic brain injury (TBI). With regards to the development of novel diagnostics, Dr. Korley has two patents for biofluid-based biomarkers for brain injury detection and outcome prognostication. In collaboration with colleagues in engineering, Dr. Korley is developing a credit card-sized microfluidic device for point-of-care measurement of TBI biofluid biomarkers. He is also a national principal investigator of two federally funded multi-center research studies that are investigating the use of biofluid-based biomarkers for 1) subject selection in clinical trials; 2) monitoring individual patient response to promising neuroprotective agents. With regards to the development of therapeutics for TBI, Dr. Korley is a principal investigator of an NINDS funded phase II adaptive design clinical trial that is investigating the optimal treatment parameters of hyperbaric oxygen that is most likely to demonstrate improvement in the rate of good neurological outcome versus control in a subsequent confirmatory trial. During the ongoing COVID-19 pandemic, Dr. Korley is leveraging his expertise in the testing of novel therapeutics to lead an NHLBI-funded multi-center clinical trial of COVID-19 convalescent plasma in outpatients (C3PO) as one of the national co-PIs. He is a member of the NINDS Neurological Sciences and Disorders A (NSD-A) study section and the National Academies of Sciences, Engineering and Medicine’s Committee on Accelerating Progress in Traumatic Brain Injury Research and Care. Dr. Korley is the recipient of the 2021 Society of Academic Emergency Medicine (SAEM) Mid-Career Investigator Award.

    Qualifications
    • KL2 Clinical Research Scholar
      Johns Hopkins Institute for Clinical and Translational Research, Baltimore, 2012
    • Emergency Medicine
      Northwestern University Feinberg School of Medicine, Department of Emergency Medicine, 2007
    • Emergency Medicine
      Northwestern University Feinberg School of Medicine, Emergency Medicine, 2007
    Center Memberships
    • Center Member
      Center for Integrative Research in Critical Care
    • Center Member
      University of Michigan Injury Prevention Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    Research Overview

    • Development of Novel Diagnostics and Therapeutics for Traumatic Brain Injury
    • Building an Emergency Medicine Learning Health System

    Recent Publications See All Publications
    • Journal Article
      Improved mortality analysis in early-phase dose-ranging clinical trials for emergency medical diseases using Bayesian time-to-event models with active comparators.
      Shi X, Wick JA, Martin RL, Beall J, Silbergleit R, Rockswold GL, Barsan WG, Korley FK, Rockswold S, Gajewski BJ. Stat Med, 2024 Aug 30; 43 (19): 3649 - 3663. DOI:10.1002/sim.10141
      PMID: 38885949
    • Journal Article
      Relationship Between Posttraumatic Headache and Depression After Mild Traumatic Brain Injury.
      Beal ML, Psoter KJ, Bechtold KT, Nagpaul V, Peters ME, Rao V, Van Meter TE, Falk H, Korley FK, Roy D. J Neuropsychiatry Clin Neurosci, 2024 Aug 8; appineuropsych20230143 DOI:10.1176/appi.neuropsych.20230143
      PMID: 39113495
    • Journal Article
      Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study.
      Yue JK, Lee YM, Sun X, van Essen TA, Elguindy MM, Belton PJ, Pisică D, Mikolic A, Deng H, Kanter JH, McCrea MA, Bodien YG, Satris GG, Wong JC, Ambati VS, Grandhi R, Puccio AM, Mukherjee P, Valadka AB, Tarapore PE, Huang MC, DiGiorgio AM, Markowitz AJ, Yuh EL, Okonkwo DO, Steyerberg EW, Lingsma HF, Menon DK, Maas AIR, Jain S, Manley GT, The TRACK-TBI Investigators . J Neurosurg, 2024 Aug 1; 141 (2): 417 - 429. DOI:10.3171/2023.11.JNS231425
      PMID: 38489823
    • Journal Article
      Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.
      Yue JK, Etemad LL, Elguindy MM, van Essen TA, Belton PJ, Nelson LD, McCrea MA, Vreeburg RJG, Gotthardt CJ, Tracey JX, Coskun BC, Krishnan N, Halabi C, Eagle SR, Korley FK, Robertson CS, Duhaime A-C, Satris GG, Tarapore PE, Huang MC, Madhok DY, Giacino JT, Mukherjee P, Yuh EL, Valadka AB, Puccio AM, Okonkwo DO, Sun X, Jain S, Manley GT, DiGiorgio AM, TRACK-TBI Investigators , Badjatia N, Barber J, Bodien YG, Fabian B, Ferguson AR, Foreman B, Gardner RC, Gopinath S, Grandhi R, Russell Huie J, Dirk Keene C, Lingsma HF, MacDonald CL, Markowitz AJ, Merchant R, Ngwenya LB, Rodgers RB, Schneider ALC, Schnyer DM, Taylor SR, Temkin NR, Torres-Espin A, Vassar MJ, Wang KKW, Wong JC, Zafonte RD. Trauma Surg Acute Care Open, 2024 9 (1): e001501 DOI:10.1136/tsaco-2024-001501
      PMID: 39081460
    • Journal Article
      Diagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study.
      Puccio AM, Yue JK, Korley FK, Okonkwo DO, Diaz-Arrastia R, Yuh EL, Ferguson AR, Mukherjee P, Wang KKW, Taylor SR, Deng H, Markowitz AJ, Sun X, Jain S, Manley GT. J Neurotrauma, 2024 Jun; 41 (11-12): 1353 - 1363. DOI:10.1089/neu.2023.0186
      PMID: 38251868
    • Journal Article
      Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study.
      Yue JK, Yuh EL, Elguindy MM, Sun X, van Essen TA, Deng H, Belton PJ, Satris GG, Wong JC, Valadka AB, Korley FK, Robertson CS, McCrea MA, Stein MB, Diaz-Arrastia R, Wang KKW, Temkin NR, DiGiorgio AM, Tarapore PE, Huang MC, Markowitz AJ, Puccio AM, Mukherjee P, Okonkwo DO, Jain S, Manley GT. J Neurotrauma, 2024 Jun; 41 (11-12): 1310 - 1322. DOI:10.1089/neu.2023.0253
      PMID: 38450561
    • Proceeding / Abstract / Poster
      Emergency Department Use of Neuroimaging and Hospitalization for Transient Ischemic Attacks in the United States: A Cross-Sectional Study
      Mamer LE, Cranford JA, Kocher KE, Korley FK, Scott PA. Journal of Clinical and Translational Science, 2024 Apr 3; 8 (s1): 98 - 98. DOI:10.1017/cts.2024.290
    • Patent
      Microfluidic device for size and deformability measurements and applications thereof
      Burns M, Krausz A, Mena S, De Beer P, Ward K, Korley F. 2024 Feb 13;