Eliza PS Tsou, PhD

 Eliza Tsou
Frederick G L Huetwell Research Professor of Rheumatology II
Assistant Professor of Internal Medicine
Assistant Professor of Pharmacology
Medical School
Office:
Michigan Medicine
Internal Medicine/Rheumatology
2800 Plymouth Road, Building 20, Room 1822
Ann Arbor, Michigan 48109
Email:
[email protected]
Phone:
Available to mentor
Eliza PS Tsou, PhD
Eliza Tsou
Assistant Professor
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • Qualifications
    • PhD, Department of Pharmaceutical Sciences. School of Pharmacy
      University at Buffalo, State University of New York, Buffalo, NY, United States
      2002 - 2008
    • BSc, Department of Pharmacy
      National Taiwan University, Taipei, Taiwan
      1997 - 2001

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Global REACH

    Recent Publications

     See All Publications
    • Journal Article
      Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
      Ma F, Tsou PS, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nature Communications, 2024 Dec 1; 15 (1): DOI:10.1038/s41467-023-44645-6
      PMID: 38172207
    • Journal Article
      Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa
      van Straalen KR, Ma F, Tsou PS, Plazyo O, Gharaee-Kermani M, Calbet M, Xing X, Sarkar MK, Uppala R, Harms PW, Wasikowski R, Nahlawi L, Nakamura M, Eshaq M, Wang C, Dobry C, Kozlow JH, Cherry-Bukowiec J, Brodie WD, Wolk K, Uluçkan Ö, Mattichak MN, Pellegrini M, Modlin RL, Maverakis E, Sabat R, Kahlenberg JM, Billi AC, Tsoi LC, Gudjonsson JE. Journal of Clinical Investigation, 2024 Feb 10; 134 (3): DOI:10.1172/JCI169225
      PMID: 38051587
    • Journal Article
      Senescent Cells Accumulate in Systemic Sclerosis Skin
      Shi B, Tsou PS, Ma F, Mariani MP, Mattichak MN, LeBrasseur NK, Chini EN, Lafyatis R, Khanna D, Whitfield ML, Gudjonsson JE, Varga J. Journal of Investigative Dermatology, 2023 Apr 1; 143 (4): 661 - 664.e5. DOI:10.1016/j.jid.2022.09.652
      PMID: 36191640
    • Journal Article
      Soluble CD13 in systemic sclerosis: clinical observations and transcriptomic insights from peripheral blood
      Ikari Y, Lu C, Rosek A, Cai A, Khanna N, St Clair J, Webber A, Foster C, Chen YC, Ali RA, Khanna D, Fox DA, Tsou PS. Arthritis Research and Therapy, 2026 Dec 1; 28 (1): DOI:10.1186/s13075-025-03723-4
      PMID: 41520101
    • Journal Article
      A Bisubstrate Inhibitor of NNMT Suppresses Myofibroblast Reprogramming to Mitigate Skin Fibrosis.
      Saba K, Kataria S, Shi B, Kumar U, Verma P, Keyorkgy J, Walters G, Chini CCS, Chini EN, Zhao T, Iyamu ID, Huang R, Tsou P-S, Amin MA, Varga J. J Invest Dermatol, 2026 Sep 9; DOI:10.1016/j.jid.2026.07.037
      PMID: 42716212
    • Journal Article
      Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation
      Maeda K, Campbell PL, Wu Q, Tsou P-S, Cooney LA, Mao-Draayer Y, Fox DA, Gurrea-Rubio M. Frontiers in Immunology, 2026 Aug 20; 17: 1918840 DOI:10.3389/fimmu.2026.1918840
    • Journal Article
      CD6-Directed Immunotherapy Targets Breast Cancer Stem Cell Function and Enhances Immune-Mediated Cytotoxicity in Triple-Negative Breast Cancer
      Gurrea-Rubio M, Sloan S, Chada A, Amarista CI, Maeda K, Campbell PL, Tsou P-S, Cooney LA, Wicha MS, Fox DA. Biomolecules, 2026 Aug 19; 16 (8): 1202 - 1202. DOI:10.3390/biom16081202
    • Proceeding / Abstract / Poster
      0170 CaMKII integrates calcium signaling and oxidative stress to promote fibrosis in scleroderma fibroblasts
      Kataria S, Ikari Y, Rosek A, Kahnna N, Vichaikul S, Wu Q, Khanna D, Tsou P. Journal of Investigative Dermatology, 2026 Jul 22; 146 (8): s30 DOI:10.1016/j.jid.2026.06.201

    Featured News & Stories

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    Protein found in rheumatic diseases causes inflammation in COVID-19 patients

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    Targeting and blocking sCD13 protein could lead to systemic sclerosis treatment

    Targeting and blocking the sCD13 protein from interacting with the B1R protein can pave the way for new fibrosis and systemic sclerosis treatments.