Costas A Lyssiotis, PhD
Maisel Research Professor of Oncology
Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
Director Academic Program
Graduate Program in Cancer Biology
Office of Graduate and Postdoctoral Studies
Co-Director of the Rogel and Blondy Center for Pancreatic Cancer
Rogel Cancer Center
Medical School
6308 Cancer Center
1150 E. Medical Center Drive
Ann Arbor, Michigan 48109-5942
[email protected]
1150 E. Medical Center Drive
Ann Arbor, Michigan 48109-5942
Available to mentor
Costas A Lyssiotis, PhD
Professor
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About
Prof. Lyssiotis obtained his bachelor’s degree in Chemistry and Biochemistry from the University of Michigan in 2004, his PhD in Chemical Biology from The Scripps Research Institute in 2010, and then completed postdoctoral training in the laboratory of Lewis C. Cantley at Harvard and Cornell. In 2015, Prof. Lyssiotis joined the faculty at the University of Michigan with appointments in the Departments of Physiology and Medicine. His lab studies the biochemical pathways and metabolic requirements that enable tumor survival and growth. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, his group aims to transition new information about these processes into targeted therapies for cancer and other diseases. He is the recipient of several junior scholar awards including being named a Lefkofsky Scholar, a Kimmel Scholar, an AACR NextGen young investigator, a Dale F. Frey Breakthrough Scientist, and a V Foundation Fellow.
Links
Lyssiotis Lab
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
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Center MemberMM-PKUHSC Joint Institute
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Center MemberRogel Cancer Center
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Center MemberGlobal REACH
Research Overview
Tumor Metabolism, Cancer Biochemistry, Immunometabolism, Tumor Microenvironment, Pancreatic Cancer, Metabolomics, Immunotherapy, Cancer-Diet Interactions, Diffuse Intrinsic Pontine Glioma (DIPG)
Recent Publications
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Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee H-J, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. Nature, 2023 Jun; 618 (7963): 151 - 158.Journal ArticleUridine-derived ribose fuels glucose-restricted pancreatic cancer.
DOI:10.1038/s41586-023-06073-w PMID: PMC10232363 -
Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Cell, 2023 Apr 13; 186 (8): 1729 - 1754.Journal ArticlePancreatic cancer: Advances and challenges
DOI:10.1016/j.cell.2023.02.014 PMID: 37059070 -
Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Nature Cancer, 2022 Nov 1; 3 (11): 1386 - 1403.Journal ArticleDifferential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells
DOI:10.1038/s43018-022-00463-1 PMID: 36411320 -
Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. Science Immunology, 2022 Nov 1; 7 (77):Journal ArticleOXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment
DOI:10.1126/SCIIMMUNOL.ABM8182 PMID: 36399539 -
Kerk SA, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, Hoffman MT, Wen HJ, Long D, Ackenhusen SE, Ramos J, Gao X, Nwosu ZC, Galbán S, Halbrook CJ, Lombard DB, Piwnica-Worms DR, Ying H, Magliano MPD, Crawford HC, Shah YM, Lyssiotis CA. Elife, 2022 Jul 1; 11:Journal ArticleMetabolic Requirement for GOT2 in Pancreatic Cancer Depends on Environmental Context
DOI:10.7554/elife.73245 PMID: 35815941 -
Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, Zhang L, Pratt MR, Keshari KR, Ying H, Lyssiotis CA. Elife, 2021 Dec 1; 10:Journal ArticleHyaluronic acid fuels pancreatic cancer cell growth
DOI:10.7554/eLife.62645 PMID: 34951587 -
Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. Nature Reviews Immunology, 2021 Oct 1; 21 (10): 637 - 652.Journal ArticleA guide to interrogating immunometabolism
DOI:10.1038/s41577-021-00529-8 PMID: 33859379 -
Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA. Nature Reviews Cancer, 2021 Aug 1; 21 (8): 510 - 525.Journal ArticleMetabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment
DOI:10.1038/s41568-021-00375-9 PMID: 34244683
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Brain cancer digital twin predicts treatment outcomes
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Brain cancer digital twin predicts treatment outcomes
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Ribbon-cutting for new pancreatic cancer program
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Two U-M PhD students named to the HHMI Gilliam Fellows Program
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Drug targets identified for pancreatic cancer
U-M researchers have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models.
