Melvin G McInnis, MD, FRCPsych

Melvin G McInnis
Thomas B and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression
Professor of Psychiatry
Professor of Learning Health Sciences
Program Director of Bipolar Psychiatry
Medical School
Available to mentor
Melvin G McInnis, MD, FRCPsych
Melvin G McInnis
Professor
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  • Center Memberships

    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Eisenberg Family Depression Center

    Recent Publications

    See All Publications
    • Journal Article
      Parental but not child reports of affective lability in offspring predict conversion to bipolar disorder in youth at increased genetic risk
      Roberts G, Ratheesh A, Fullerton JM, Cignarella C, Francis E, Kamali M, Stapp EK, Ghaziuddin N, Hulvershorn L, McInnis MG, Wilcox HC, Edenberg HJ, Nurnberger JI, Mitchell PB. Journal of Affective Disorders, 2026 Nov 1; 412: DOI:10.1016/j.jad.2026.122077
    • Journal Article
      Predicting suicidal ideation from depression screening data: A network-augmented machine learning approach.
      Kim H, Yocum AK, McInnis MG, Sperry SH. J Affect Disord, 2026 Mar 23; 121671 DOI:10.1016/j.jad.2026.121671
      PMID: 41881118
    • Journal Article
      Potential Impact of Childhood Abuse on Quality of Life During Mood-Stabilising Treatment in Individuals Living With Bipolar Disorder
      Wrobel AL, Dean OM, Lotfaliany M, Berk M, Sylvia LG, Thase ME, Deckersbach T, Tohen M, McInnis MG, Kocsis JH, Shelton RC, McElroy SL, Turner A, Nierenberg AA. Bipolar Disorders, 2026 Mar 1; 28 (2): DOI:10.1111/bdi.70079
      PMID: 41677164
    • Journal Article
      Adverse childhood experiences and cardiometabolic risk factors in people with bipolar disorder
      Turner A, Kuperberg M, McGovern H, Wrobel A, Dean OM, Berk M, Sylvia L, McElroy SL, Tohen M, Shelton RC, Iosifescu DV, Thase ME, Kocsis JH, Ostacher MJ, Deckersbach T, McInnis MG, Köhler-Forsberg O, Nierenberg AA. Journal of Affective Disorders, 2026 Jan 15; 393: DOI:10.1016/j.jad.2025.120270
      PMID: 40935250
    • Journal Article
      Clinical outcomes of youth at familial risk for bipolar disorder: A 2-year longitudinal, observational study
      Pandina G, DelBello MP, Rassnick S, Solanki B, Canuso CM, Fristad MA, Correll CU, Nurnberger JI, Singh MK, McInnis MG, Atkinson S, Stedman M, Goes FS, Strakowski SM, Greer TL, Nierenberg AA, Salvadore G, Drevets WC. Journal of Affective Disorders, 2026 Jan 15; 393: DOI:10.1016/j.jad.2025.120492
      PMID: 41106637
    • Journal Article
      Considerations in the development of learning health networks for mood disorders
      Lipschitz JM, Adler C, Almeida JRC, Assari S, Bond DJ, Breitzig MT, DePaulo JR, El-Mallakh R, Fiedorowicz J, Freshley J, Fries GR, Frye MA, Goes FS, Gonzalez R, Huber R, Jamison K, Liu G, Machado-Vieira R, Mahon P, McInnis MG, Meyer TD, Youssef NA, Nurnberger JI, Ostacher M, Parikh SV, Pinjari O, Raj K, Respino M, Sanches M, Schneck CD, Singh MK, Soares JC, Strakowski SM, Sullivan A, Suppes T, Thase ME, Wang P, Waxmonsky JA, Yurgelun-Todd D, Zandi PP, Burdick KE. Journal of Affective Disorders, 2026 Jan 15; 393: DOI:10.1016/j.jad.2025.119904
      PMID: 40652981
    • Journal Article
      Clinical Judgment and the Architecture of Reasoning in Psychiatry
      McInnis MG, DePaulo JR. Acta Psychiatrica Scandinavica, 2026 Jan 1; 153 (1): 3 - 5. DOI:10.1111/acps.70047
      PMID: 41265865
    • Journal Article
      Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition
      Kraft JD, Suzuki T, Menkes MW, Andrews CM, McInnis MG, Deldin PJ, Tso IF. Clinical Neurophysiology, 2025 Dec 1; 180: DOI:10.1016/j.clinph.2025.2111386
      PMID: 41124888

    Featured News & Stories

    Close-up of a studio microphone on a boom arm in front of a blurred audio mixing console and equipment, suggesting a podcast or radio recording setup.
    Research News

    Hidden Brain “Rethinking Depression”: Dr. Jonathan Rottenberg highlights Dr. Melvin McInnis

    Cornell psychologist Jonathan Rottenberg, Ph.D., reflects on recovering from depression and reconnecting with Melvin McInnis, M.D., in Hidden Brain’s “Rethinking Depression.”
    Colorful, wooden Tetris-style blocks arranged in a partially completed puzzle on a blue background, with one bright red piece set aside from the rest.
    Research News

    Clinical Judgment and the Architecture of Reasoning in Psychiatry

    "Clinical Judgment and the Architecture of Reasoning in Psychiatry," editorial from Melvin McInnis, M.D., director of the Heinz C. Prechter Bipolar Research Program and Raymond DePaulo, M.D., Johns Hopkins University
    A person sits on a couch using a laptop, with a glowing AI symbol appearing on the screen. The text above reads, "Ask the Doctor: How Safe Is AI for Mental Health Information?"
    Research News

    New "Ask the Doctor" column written by Dr. Melvin McInnis for bpHope

    New "Ask the Doctor" column written by Dr. Melvin McInnis for bpHope
    Heinz C. Prechter Bipolar Research logo with the University of Michigan block M on a dark blue background
    Research News

    A Letter from the Director

    A letter from the Director of the Heinz C. Prechter Bipolar Research Program.
    Smiling photo of the Wagners standing in front of the Caribbean in Grand Cayman.
    Philanthropy News

    From seeking answers to fueling progress

    Patricia and Jerry Wagner have provided ongoing, dedicated support to the Heinz C. Prechter Bipolar Research Program at University of Michigan Heatlh.
    Illustration depicting mental health and therapy. In the center, there is a large clipboard with a drawing of a human head in profile, showing tangled lines inside the brain area, symbolizing confusion or mental distress. To the left, a person is lying on a therapy couch, talking, with a speech bubble showing a spiral. Next to them, a therapist sits on a chair taking notes on a laptop. On the right, another person sits on stacked books with their head in their hands and orange stress lines above their head.
    Research News

    Prechter Program Director featured in WebMD article

    Dr. Melvin McInnis discusses the latest treatments for bipolar disorder in a WebMD interview.