Andrzej A Dlugosz, MD
Poth Professor of Cutaneous Oncology
Associate Chair, Department of Dermatology
Associate Director for Basic Science, Rogel Cancer Center
Professor of Dermatology and Professor of Cell and Developmental Biology
Medical School
Available to mentor
Andrzej A Dlugosz, MD
Professor
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About
Work in my lab is focused on basal cell carcinoma, other Hedgehog-driven cancers, and a virus-associated cancer called Merkel cell carcinoma. We have developed and characterized multiple genetically-engineered mouse models to address fundamental questions in cancer biology, including identifying potential cells of origin of cancer, functions of oncogenic signaling in tumor maintenance, significance of cross-talk between signaling pathways in cancer, interactions between tumor cells and their microenvironment, and the regulation of tumor cell fate.
Qualifications
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MDPennsylvania State University College of Medicine, USA
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
Recent Publications
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Plazyo O, Chopp LB, Peela R, Young K, Zhang H, Bogle R, Hesson A, Langen ES, Bergin IL, Syu L-J, Erba J, Kirma J, Dey P, Zhang L, Sarkar MK, Swindell WR, Gallagher KA, Ward NL, Singer K, Kahlenberg JM, Billi AC, Dlugosz AA, Ganesh SK, Tsoi LC, Gudjonsson JE. Circulation, 2026 Apr 9;Journal ArticleDefective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network.
DOI:10.1161/CIRCULATIONAHA.125.076218 PMID: 41953989 -
Eido A, Gonzalez ME, Syu L, Dlugosz AA, Kleer CG. Cancer Research, 2026 Apr 5; 86 (7_Supplement): 6096 - 6096.Journal ArticleAbstract 6096: Characterization of a novel doxycycline inducible model of EZH2 overexpression in mammary glands
DOI:10.1158/1538-7445.am2026-6096 -
Pedersen EA, Grachtchouk M, Harms PW, Furgal AKC, Wilbert D, Hoover A, Hodgson DV, Fiehler K, Alam A, Lingam N, Wong SY, Verhaegen ME, Dlugosz AA. Jid Innovations, 2026 Mar 1; 6 (2):Journal ArticleSpatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice
DOI:10.1016/j.xjidi.2025.100441 -
Murad N, Xu Z, Zhang J, Liu X, Ramawickrama P, Tao R, Rivero-Hinojosa S, Schoof M, Schüller U, Chen Q, Rood BR, Packer R, Nair LR, Grachtchouk M, Dlugosz A, Yang J, Taylor MD, Pei H, Pei Y. Neuro Oncol, 2026 Feb 18;Journal ArticleSpatiotemporal Role of GLI2 in Driving SHH-Medulloblastoma Tumorigenesis.
DOI:10.1093/neuonc/noag033 PMID: 41706711 -
Aqeel J, Kondrachuk O, Syed TA, Holtz CE, Harms KL, Angeles CV, Dlugosz AA, Pedersen EA. Cancer Research, 2026 Jan 15; 86 (1_Supplement): a018 - a018.Journal ArticleAbstract A018: Investigating the fibroblastic phenotype of dermatofibrosarcoma protuberans in primary tumors and non-fusion-bearing fibroblasts
DOI:10.1158/1538-7445.fusionpositive26-a018 -
Pedersen EA, Syu L-J, Dlugosz AA, Verhaegen ME. Cancer Research, 2026 Jan 15; 86 (1_Supplement): a019 - a019.Journal ArticleAbstract A019: Investigating of the impact of COL1A1::PDGFB fusion in mouse Col1a2+ dermal embryonic fibroblasts as a potential cell of origin of dermatofibrosarcoma protuberans
DOI:10.1158/1538-7445.fusionpositive26-a019 -
Veniaminova NA, Grachtchouk M, Dlugosz AA, Wong SY. Methods in Molecular Biology Clifton N J, 2026 Jan 1; 3031: 185 - 192.Journal ArticleA Protocol to Prepare and Stain Dorsal Skin Whole Mounts from Mice
DOI:10.1007/978-1-0716-5253-4_13 PMID: 42149447 -
Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleIdentification of Meibomian gland stem cell populations and mechanisms of aging
DOI:10.1038/s41467-025-56907-6 PMID: 39955307
