Andrzej A Dlugosz, MD

 Andrzej A. Dlugosz
Professor
Available to mentor
Andrzej A Dlugosz, MD
Andrzej A. Dlugosz
Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • About

    Work in my lab is focused on basal cell carcinoma, other Hedgehog-driven cancers, and a virus-associated cancer called Merkel cell carcinoma. We have developed and characterized multiple genetically-engineered mouse models to address fundamental questions in cancer biology, including identifying potential cells of origin of cancer, functions of oncogenic signaling in tumor maintenance, significance of cross-talk between signaling pathways in cancer, interactions between tumor cells and their microenvironment, and the regulation of tumor cell fate.

    Qualifications
    • MD
      Pennsylvania State University College of Medicine, USA

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center

    Recent Publications

     See All Publications
    • Journal Article
      Functional Roles of Wnt/β-catenin Pathway Components in Pre-Basal Cell Carcinoma-like Cell Proliferation and Survival.
      Zhu X, Dlugosz AA, Seykora JT, Millar SE. J Invest Dermatol, 2026 Oct 9; DOI:10.1016/j.jid.2026.09.856
      PMID: 42854951
    • Proceeding / Abstract / Poster
      0809 Matrisome alterations in aged human skin and their impact on skin cancer development
      Zhang Z, He T, Guo C, Marella S, Billi A, Gudjonsson JE, Dlugosz AA, Fisher GJ, Voorhees JJ, Quan T. Journal of Investigative Dermatology, 2026 Jul 22; 146 (8): s140 DOI:10.1016/j.jid.2026.06.840
    • Journal Article
      0818 Age-related dermal microenvironment drives keratinocyte skin cancer initiation and progression
      Quan T, Guo C, Kim AJ, Kim J, Qin Z, He T, Voorhees JJ, Dlugosz AA, Fisher GJ. Journal of Investigative Dermatology, 2026 Jul 22; 146 (8): s141 DOI:10.1016/j.jid.2026.06.849
    • Proceeding / Abstract / Poster
      0997 VGLL3-TEAD interaction as a therapeutic target in cutaneous lupus
      Van Drongelen V, Griffin E, Rew JE, Young K, Gharaee-Kermani M, Bogle R, Tsoi LC, Kahlenberg M, Dlugosz AA, Gudjonsson JE, Billi AC. Journal of Investigative Dermatology, 2026 Jul 22; 146 (8): s172 DOI:10.1016/j.jid.2026.06.1028
    • Preprint
      An immunocompetent Merkel cell carcinoma model for preclinical studies
      Verhaegen ME, Bhatia S, Singer KL, Baumbick M, Huang P-W, Syu L-J, Wilbert D, Selig A, Farjo GA, Walter E, Wolinski N, Furgal A, Galloway DA, Harms PW, Cieslik M, Dlugosz AA. 2026 Jun 28; bioRxiv, DOI:10.64898/2026.06.25.734228
    • Journal Article
      Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network
      Plazyo O, Chopp LB, Peela R, Young K, Zhang H, Bogle R, Hesson A, Langen ES, Bergin IL, Syu LJ, Erba J, Kirma J, Dey P, Zhang L, Sarkar MK, Swindell WR, Gallagher KA, Ward NL, Singer K, Kahlenberg JM, Billi AC, Dlugosz AA, Ganesh SK, Tsoi LC, Gudjonsson JE. Circulation, 2026 Jun 2; 153 (22): DOI:10.1161/CIRCULATIONAHA.125.076218
      PMID: 41953989
    • Journal Article
      Spatiotemporal role of GLI2 in driving SHH-medulloblastoma tumorigenesis
      Murad N, Xu Z, Zhang J, Liu X, Ramawickrama P, Tao R, Rivero-Hinojosa S, Schoof M, Schüller U, Chen Q, Rood BR, Packer R, Nair LR, Grachtchouk M, Dlugosz A, Yang J, Taylor MD, Pei H, Pei Y. Neuro Oncology, 2026 Jun 1; 28 (6): 1541 - 1555. DOI:10.1093/neuonc/noag033
      PMID: 41706711
    • Proceeding / Abstract / Poster
      0863 Orthotopic injection of syngeneic melanoma cell lines into mouse ear skin reveals variable engraftment, metastasis, and skin depigmentation
      Holtz C, Kondrachuk O, Syed T, Aqeel J, Dlugosz A, Angeles C, Pedersen E. 2026 May 13;