Lonnie Shea

 portrait of Lonnie Shea
Steven A Goldstein Collegiate Professor of Biomedical Engineering
Professor of Biomedical Engineering, College of Engineering and Medical School
Professor of Chemical Engineering, College of Engineering
Professor of Surgery, Medical School
[email protected]
Available to mentor
Lonnie Shea
portrait of Lonnie Shea
Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    The Shea Lab works at the interface of regenerative medicine, biomaterials, and systems biology. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation, promote tissue regeneration or function, and monitor disease initiation or progression.

    Links
    • https://shearesearch.engin.umich.edu/

    Qualifications
    • Postdoctoral Fellow
      University of Michigan, School of Dentistry, USA
      Postdoctoral Fellowship
    • PhD
      University of Michigan, USA

    Center Memberships
    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Biointerfaces Institute
    • Center Member
      Rogel Cancer Center
    • Center Member
      Biosciences Initiative
    • Center Member
      Regenerative Medicine Resource Center
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    Of particular emphasis in the lab is:

    Applying the controllable microenvironments to in vitro and in vivo models of tissue formation, including nerve regeneration, and islet formation and function.
    Engineering nanoparticles or environments to modulate innate and adaptive immune responses for autoimmune and allergic disease, responses to trauma, and to prevent rejection of transplanted cells or tissue.
    Developing diagnostic systems for cancer, autoimmune disease, and transplant rejection that can detect immune dysregulation associated with disease onset, and monitor for the response to therapy.

    Recent Publications

     See All Publications
    • Journal Article
      Gamma Irradiation of Poly(lactide-co-glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates
      King JL, Spencer C, Youngblood R, Crumley K, Bealer E, Rios PD, Joshi I, Ghani S, Isa D, McGarrigle JJ, Cook D, Locke C, Abraham A, Clark A, Oberholzer J, Shea LD. Biotechnology and Bioengineering, 2026 Mar 1; 123 (3): 742 - 751. DOI:10.1002/bit.70134
      PMID: 41439800
    • Preprint
      Microtubule Stabilization and Biomaterial Guidance Synergize to Enhance CST Regeneration and Motor Recovery After Chronic SCI
      Nekanti U, Sakthivel PS, Nishi RA, Anzalone A, Dumont CM, Bin Lee J, McDonald S, Song H, Obenaus A, Gershon PD, Bradke F, Shea LD, Cummings BJ, Anderson AJ. 2026 Feb 11; bioRxiv, DOI:10.64898/2026.02.05.703927
    • Journal Article
      Longitudinal monitoring of type 1 diabetes progression to disease onset
      King JL, Roy J, Urie RR, Bealer E, Crumley K, Rad L, Soleimanpour SA, Shea LD. Science Advances, 2026 Jan 28; 12 (5): DOI:10.1126/sciadv.adw8946
      PMID: 41604487
    • Journal Article
      Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche.
      Pereles RS, Roy J, Brooks MD, Wicha MS, Jeruss JS, Shea LD, Orbach SM. Biotechnol Bioeng, 2026 Jan 10; DOI:10.1002/bit.70140
      PMID: 41518488
    • Journal Article
      STING/type I interferon pathway is required for antigen-containing PLGA nanoparticle- and apoptotic cell-induced CD4+ T cell tolerance
      Podojil JR, Cogswell AC, Neef T, Chiang MY, Beddow SA, Arellano G, Kakade S, McCarthy DP, Elhofy A, Harp CT, Khan M, Meeks JJ, Xu D, Shea LD, Miller SD. Science Advances, 2026 Jan 2; 12 (1): eadv8860 DOI:10.1126/sciadv.adv8860
      PMID: 41481727
    • Journal Article
      Nanoparticle induction of antigen-presenting monocyte-derived dendritic cells relieves immunosuppression and inhibits metastasis
      Ma JA, Griffin KV, Kang K, Diener A, Schrack IA, Bealer EJ, Rad LM, Pereles RS, Jeruss JS, Shea LD. Cell Biomaterials, 2026 Jan 1; DOI:10.1016/j.celbio.2025.100343
    • Journal Article
      "Immunomodulatory nanoparticles elicit antifibrotic monocyte activation to resolve murine pulmonary fibrosis".
      Viola H, Carter H, Griffin K, Costa RM, McDonald R, Callow B, de Los Santos FG, Martinez M, Chen R, Hunter Z, Luker G, Moore BB, Shea L. bioRxiv, 2025 Dec 24; DOI:10.64898/2025.12.22.696047
      PMID: PMC12776067
    • Journal Article
      Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
      Lietzke AC, Walker EM, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D’Ancona E, Henry-Kanarek B, Davidson RK, Li J, Reck EC, Wu Y, Arnipalli M, Pham JP, Mundada L, Sidarala V, Herron TJ, Coronel MM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA. Nature Communications, 2025 Dec 1; 16 (1): DOI:10.1038/s41467-025-66022-1
      PMID: 41372150

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