Yan Zhang, PhD
Associate Professor of Biological Chemistry
Associate Professor of Microbiology and Immunology
Medical School
[email protected]
Available to mentor
Yan Zhang, PhD
Associate Professor
Manage Your Profile
Research Overview
The overarching goal of my lab is (i) to decipher the fascinating biology of diverse CRISPR-Cas systems in bacteria, and (ii) to convert their novel features into new biotechnologies and gene therapy strategies for treating human diseases. We use a multidisciplinary approach blending cell biology, genetics, biochemistry, next-generation sequencing, bioinformatics, and animal models to uncover brand-new CRISPR systems from nature, invent gene-editing tools, and leverage CRISPR therapeutics to tackle a wide range of genetic disorders.
Links
https://yanzhanglab.med.umich.edu/
Recent Publications
-
Geslewitz WE, Cardenas A, Zhou X, Zhang Y, Criss AK, Steven Seifert H. Mbio, 2024 Feb 1; 15 (2):Journal ArticleDevelopment and implementation of a Type I-C CRISPR-based programmable repression system for Neisseria gonorrhoeae
DOI:10.1128/mbio.03025-23 PMID: 38126782 -
Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Nam KH, Zhang Y, Ke A. Molecular Cell, 2024 Feb 1; 84 (3): 463 - 475.e5.Journal ArticleExploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications
DOI:10.1016/j.molcel.2023.12.034 PMID: 38242128 -
Hou Z, Tan R, Zhang Y. Trends in Biochemical Sciences, 2023 Jan 1; 48 (1): 9 - 10.Journal ArticleSnapshots of a tiny ancestral nuclease of Cas9
DOI:10.1016/j.tibs.2022.08.008 PMID: 36100522 -
Tan R, Krueger RK, Gramelspacher MJ, Zhou X, Xiao Y, Ke A, Hou Z, Zhang Y. Molecular Cell, 2022 Feb 17; 82 (4): 852 - 867.e5.Journal ArticleCas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
DOI:10.1016/j.molcel.2021.12.032 PMID: 35051351 -
Hou Z, Hu C, Ke A, Zhang Y. Current Protocols, 2022 Feb 1; 2 (2):Journal ArticleIntroducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3
DOI:10.1002/cpz1.361 PMID: 35129865 -
Gramelspacher MJ, Hou Z, Zhang Y. Methods, 2020 Feb 1; 172: 32 - 41.Journal ArticleBiochemical characterization of RNA-guided ribonuclease activities for CRISPR-Cas9 systems
DOI:10.1016/j.ymeth.2019.06.018 PMID: 31228550 -
Dolan AE, Hou Z, Xiao Y, Gramelspacher MJ, Heo J, Howden SE, Freddolino PL, Ke A, Zhang Y. Molecular Cell, 2024 Aug 14; 74 (5): 936 - 950.e5.Journal ArticleIntroducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas
DOI:10.1016/j.molcel.2019.03.014 -
Hou Z, Zhang Y. Science, 2019 Jan 1; 364 (6448): 25 - 26.Journal ArticleInserting DNA with CRISPR
DOI:10.1126/science.aay2056 PMID: 31273110
Featured News & Stories
Department News
The Zhang lab publishes a research article in Investigative Ophthalmology & Visual Science
The Zhang lab from U-M Biological Chemistry publishes a research article in Investigative Ophthalmology & Visual Science.
Health Lab
CRISPR study reveals surprising role of Cas9 as a guardian of bacterial defense
New research overturns a common assumption about CRISPR Cas9—that unbound from its usual RNA partners, the “empty” or apo form of Cas9 is functionless.
Great Minds, Greater Discoveries Stories
Research Scout Scholars: Shahzad Mian, MD, Lev Prasov, MD, PhD & Yan Zhang, PhD
Meet Shahzad Mian, MD, Lev Prasov, MD, PhD and Yan Zhang, PhD, Great Minds Research Scouts scholars at the University of Michigan Medical School.
Department News
Congratulations to Renke Tan, PhD
Biological Chemistry PhD student Renke Tan of the Zhang lab at U-M Medical School defends her doctoral thesis.
Department News
Five Biological Chemistry faculty members receive promotions
Yan Zhang, PhD, Jeanne Stuckey, PhD, Markus Ruetz, PhD, Michael Cianfrocco, PhD, and Wei Cheng, PhD, have been promoted.
Department News
Yan Zhang, PhD, receives a CAREER award from the National Science Foundation
Assistant Professor Yan Zhang of the Department of Biological Chemistry at U-M Medical School is the recipient of an NSF CAREER award.
