Vaibhav Sahai, MBBS, MS
Department of Internal Medicine
1500 E. Medical Center Drive
Ann Arbor, MI 48109
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Qualifications
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Chief FellowNorthwestern University, Internal Medicine - Hematology and Oncology, Evanston, United States
2012 - 2013
Chief Fellow
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FellowNorthwestern University, Internal Medicine - Hematology and Oncology, Evanston, United States
2010 - 2012
Clinical Fellowship
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ResidentUniversity of Pittsburgh Medical Center, Internal Medicine, Pittsburgh, United States
2007 - 2010
Residency
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Postdoctoral FellowHarvard Medical School, Radiology, Boston, United States
2006 - 2007
Postdoctoral Fellowship
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DiplomaBioinformatics Institute of India Noida, Medical Informatics, Noida, Noida, India, India
2004 - 2005
Other
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MSHarvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, United States
2005 - 2006
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MB BSGovernment Medical College, One Circular Road, Amritsar, Punjab, India, 143001, India
1998 - 2004
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberRogel Cancer Center
Research Overview
The focus of my research lies in experimental therapeutics in pancreaticobiliary cancers via a molecular-based approach in the laboratory. As the Lindsay Olson Pancreatic Cancer Research Professor and Section Head of Gastrointestinal Oncology in the Division of Hematology and Oncology, I am privileged to see patients within the multidisciplinary pancreatic and liver tumor programs. As a tenured clinical and translational researcher, I specialize in the design, implementation, and execution of investigator-initiated and sponsored phase 1/2 clinical trials to investigate novel compounds in patients with pancreas and biliary cancers based on pre-clinical investigation conducted either in my lab or as team science projects. As the Director of Pancreaticobiliary biobanks at the Rogel Cancer Center my translational lab generates and uses organoid models for the therapeutic investigation of novel compounds in pancreaticobiliary cancers. Additionally, I have an imaging lab with focus on imaging software development and research in morphomics and radiomics in pancreaticobiliary cancers. As the Founding Director of the Tumor Response Assessment Core (TRAC) my lab provides standardized, precision imaging metrics for patients enrolled on clinical trials at the Rogel Cancer Center.
Recent Publications
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Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. Clin Cancer Res, 2026 Oct 15; 32 (20): 4563 - 4570.Journal ArticleA Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.
DOI:10.1158/1078-0432.CCR-25-1114 PMID: PMC13669724 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipClinical Trial Protocol1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.34519891 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipData from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.c.8775241 -
Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15;Additional ScholarshipSupplementary Figures and Table1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
DOI:10.1158/1078-0432.34519885 -
Akbar AR, Leyva A, Esnakula A, Hasanov E, Noonan A, Meng L, Tsai S, Sahai V, Malla M, Mukherjee S, Manne U, Parwani A, Chen W, Manne A, Niazi MKK. Communications Medicine, 2026 Oct 7;Journal ArticleInferring clinically relevant molecular subtypes of pancreatic cancer from routine histopathology using deep learning
DOI:10.1038/s43856-026-01952-5 -
Diamond-Rossi SA, Rothe M, Garrett-Mayer E, Pisick E, Bleeker J, Ganti AK, Meric-Bernstam F, Moyers JT, Nair SG, Kadakia KC, Rohatgi N, Sahai V, Vijayvergia N, Gold PJ, Sharma MR, Hinshaw DC, Gregory A, Grantham GN, Halabi S, Schilsky RL. JCO Precis Oncol, 2026 Oct; 10 (10): e2600703Journal ArticleCobimetinib + Vemurafenib in Patients With BRAF V600E-Mutant Papillary Thyroid and Biliary Tract Cancers: Results From the TAPUR Study.
DOI:10.1200/PO-26-00703 PMID: 42886887 -
Pasternak AL, Tackett W, Banerjee M, Paul S, Bertucci-Richter E, Zhou X, Sahai V, Hertz DL. Pharmacogenomics Journal, 2026 Oct 1; 26 (5):Journal ArticleReal-world analysis of genotype-guided treatment for carriers of actionable DPYD and UGT1A1 variants
DOI:10.1038/s41397-026-00432-2 -
Cheng Y-S, Zou Y, Montle A, Fouladdel S, Bogard A, Peterson N, Sahai V, Nagrath S. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a077 - a077.Proceeding / Abstract / PosterAbstract A077: Integrated biomarker analysis of circulating tumor cells, circulating tumor DNA and extracellular vesicles in a single blood draw: Longitudinal monitoring for pancreatic cancer
DOI:10.1158/1538-7445.pancreatic26-a077
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