Vaibhav Sahai, MBBS, MS

Vaibhav Sahai
Associate Professor
Office:
University of Michigan Medical School
Department of Internal Medicine
1500 E. Medical Center Drive
Ann Arbor, MI 48109
Available to mentor
Vaibhav Sahai, MBBS, MS
Vaibhav Sahai
Associate Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • Qualifications

    • Chief Fellow
      Northwestern University, Internal Medicine - Hematology and Oncology, Evanston, United States
      2012 - 2013
      Chief Fellow
    • Fellow
      Northwestern University, Internal Medicine - Hematology and Oncology, Evanston, United States
      2010 - 2012
      Clinical Fellowship
    • Resident
      University of Pittsburgh Medical Center, Internal Medicine, Pittsburgh, United States
      2007 - 2010
      Residency
    • Postdoctoral Fellow
      Harvard Medical School, Radiology, Boston, United States
      2006 - 2007
      Postdoctoral Fellowship
    • Diploma
      Bioinformatics Institute of India Noida, Medical Informatics, Noida, Noida, India, India
      2004 - 2005
      Other
    • MS
      Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, United States
      2005 - 2006
    • MB BS
      Government Medical College, One Circular Road, Amritsar, Punjab, India, 143001, India
      1998 - 2004

    Center Memberships

    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Rogel Cancer Center

    Research Overview

    The focus of my research lies in experimental therapeutics in pancreaticobiliary cancers via a molecular-based approach in the laboratory. As the Lindsay Olson Pancreatic Cancer Research Professor and Section Head of Gastrointestinal Oncology in the Division of Hematology and Oncology, I am privileged to see patients within the multidisciplinary pancreatic and liver tumor programs. As a tenured clinical and translational researcher, I specialize in the design, implementation, and execution of investigator-initiated and sponsored phase 1/2 clinical trials to investigate novel compounds in patients with pancreas and biliary cancers based on pre-clinical investigation conducted either in my lab or as team science projects. As the Director of Pancreaticobiliary biobanks at the Rogel Cancer Center my translational lab generates and uses organoid models for the therapeutic investigation of novel compounds in pancreaticobiliary cancers. Additionally, I have an imaging lab with focus on imaging software development and research in morphomics and radiomics in pancreaticobiliary cancers. As the Founding Director of the Tumor Response Assessment Core (TRAC) my lab provides standardized, precision imaging metrics for patients enrolled on clinical trials at the Rogel Cancer Center.

    Recent Publications

    See All Publications
    • Journal Article
      A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02.
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. Clin Cancer Res, 2026 Oct 15; 32 (20): 4563 - 4570. DOI:10.1158/1078-0432.CCR-25-1114
      PMID: PMC13669724
    • Additional Scholarship
      Clinical Trial Protocol1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.34519891
    • Additional Scholarship
      Data from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.c.8775241
    • Additional Scholarship
      Supplementary Figures and Table1 from A Phase II Multicenter Trial of Rucaparib and Nivolumab as Maintenance Therapy in Patients with Advanced Biliary Tract Cancer: BilT-02
      Mohan A, Griffith KA, Goff LW, Crysler O, Enzler T, Cardin DB, Gunchick V, Tsang AP, Dippman D, Young AS, Olivei AC, Mannan R, Rao A, Frankel TL, Kumar-Sinha C, Zalupski MM, Sahai V. 2026 Oct 15; DOI:10.1158/1078-0432.34519885
    • Journal Article
      Inferring clinically relevant molecular subtypes of pancreatic cancer from routine histopathology using deep learning
      Akbar AR, Leyva A, Esnakula A, Hasanov E, Noonan A, Meng L, Tsai S, Sahai V, Malla M, Mukherjee S, Manne U, Parwani A, Chen W, Manne A, Niazi MKK. Communications Medicine, 2026 Oct 7; DOI:10.1038/s43856-026-01952-5
    • Journal Article
      Cobimetinib + Vemurafenib in Patients With BRAF V600E-Mutant Papillary Thyroid and Biliary Tract Cancers: Results From the TAPUR Study.
      Diamond-Rossi SA, Rothe M, Garrett-Mayer E, Pisick E, Bleeker J, Ganti AK, Meric-Bernstam F, Moyers JT, Nair SG, Kadakia KC, Rohatgi N, Sahai V, Vijayvergia N, Gold PJ, Sharma MR, Hinshaw DC, Gregory A, Grantham GN, Halabi S, Schilsky RL. JCO Precis Oncol, 2026 Oct; 10 (10): e2600703 DOI:10.1200/PO-26-00703
      PMID: 42886887
    • Journal Article
      Real-world analysis of genotype-guided treatment for carriers of actionable DPYD and UGT1A1 variants
      Pasternak AL, Tackett W, Banerjee M, Paul S, Bertucci-Richter E, Zhou X, Sahai V, Hertz DL. Pharmacogenomics Journal, 2026 Oct 1; 26 (5): DOI:10.1038/s41397-026-00432-2
    • Proceeding / Abstract / Poster
      Abstract A077: Integrated biomarker analysis of circulating tumor cells, circulating tumor DNA and extracellular vesicles in a single blood draw: Longitudinal monitoring for pancreatic cancer
      Cheng Y-S, Zou Y, Montle A, Fouladdel S, Bogard A, Peterson N, Sahai V, Nagrath S. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): a077 - a077. DOI:10.1158/1538-7445.pancreatic26-a077

    Featured News & Stories

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