Roger D Cone

 Roger D. Cone, PhD
Tadataka Yamada Distinguished University Professor of Molecular and Integrative Physiology
Mary Sue Coleman Director of the Life Sciences Institute
Research Professor, Life Sciences Institute
Professor of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts
Professor of Molecular and Integrative Physiology, Medical School
[email protected]
Available to mentor
Roger D Cone
Roger D. Cone, PhD
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    • Center Memberships
    • Center Member
      Caswell Diabetes Institute

    Recent Publications

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    • Preprint
      Attractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body Weight
      Buscaglia P, Bowman KR, Lawler K, Hernandez CC, Scotucci J, Bounds R, Keogh JM, Henning E, Cone RD, Farooqi IS, Sebag JA. 2026 Jan 19; medRxiv, DOI:10.64898/2026.01.12.26343722
    • Journal Article
      Melanocortin receptors in GtoPdb v.2025.3
      Caruso V, Tatro JB, Schiöth H, Pouton C, Mountjoy KG, Hruby VJ, Haskell-Luevano C, Gantz I, Fong TM, Farooqi S, Eberle AN, Cone RD, Clark AJL, Chai B-X, Wikberg JES. IUPHAR/BPS Guide to Pharmacology CITE, 2025 Oct 20; 2025 (3): DOI:10.2218/gtopdb/f38/2025.3
    • Journal Article
      An Improved Synthesis of Compound 11, a Unique Bicyclic Melanocortin-3 Antagonist
      Joy ST, Dahir NS, Cone RD, Mapp AK. Peptide Science, 2025 Jan 1; 117 (1): DOI:10.1002/pep2.24385
    • Journal Article
      Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis
      Lu ZA, Ploner A, Birgegård A, Adan R, Alfredsson L, Ando T, Andreassen O, Baker J, Bergen A, Berrettini W, Boden J, Boehm I, Perica VB, Brandt H, Breen G, Bryois J, Buehren K, Bulik C, Burghardt R, Cassina M, Cichon S, Coleman J, Cone R, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, De Zwaan M, Dedoussis G, Desocio J, Dick D, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan L, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fischer K, Föcker M, Foretova L, Forstner A, Forzan M, Franklin C, Gallinger S, Giegling I, Giusti-Rodríguez P, Gonidakis F, Gordon S, Gorwood P, Mayora MG, Grove J, Guillaume S, Guo Y, Hakonarson H, Halmi K, Hanscombe K, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Herms S, Herpertz-Dahlmann B, Herzog W, Hinney A, Horwood LJ, Hübel C, Huckins L, Hudson J, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kalsi G, Kaminská D, Kaplan A, Kaprio J, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy J, Kennedy M, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klareskog L, Klump K. Schizophrenia Bulletin, 2024 Sep 1; 50 (5): 1255 - 1265. DOI:10.1093/schbul/sbae087
      PMID: 38848516
    • Journal Article
      Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
      Dahir NS, Gui Y, Wu Y, Sweeney PR, Rouault AAJ, Williams SY, Gimenez LE, Sawyer TK, Joy ST, Mapp AK, Cone RD. Journal of Clinical Investigation, 2024 Jul 15; 134 (14): DOI:10.1172/JCI178250
      PMID: 39007271
    • Preprint
      Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia.
      Li L, Hernandez CC, Gimenez LE, Xu B, Dahir NS, Swati , Birnbaum SG, Cone RD, Liu C. 2024 Jun 8; DOI:10.1101/2024.06.07.597973
      PMID: 38895206
    • Preprint
      Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States.
      Peisley A, Hernandez CC, Dahir NS, Koepping L, Raczkowski A, Su M, Ghamari-Langroudi M, Ji X, Gimenez LE, Cone RD. 2024 Jun 8; DOI:10.1101/2024.06.07.597981
      PMID: 38895219
    • Journal Article
      Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design
      Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Journal of Medicinal Chemistry, 2024 Feb 22; 67 (4): 2690 - 2711. DOI:10.1021/acs.jmedchem.3c01822
      PMID: 38345933

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    In the U.S., dietary obesity has a prevalence of 40% and obesity increases the risk of other chronic diseases such as heart disease and diabetes. Even though anorexia nervosa has a prevalence of 1%, it is the second-highest death rate of any mental illness. Roger Cone discusses how melanocortin receptors can be used to treat both obesity and anorexia.
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