Roger D Cone

 Roger D. Cone, PhD
Research Professor
Email:
[email protected]
Available to mentor
Roger D Cone
Roger D. Cone, PhD
Research Professor
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    • Center Memberships
    • Center Member
      Caswell Diabetes Institute

    Recent Publications

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    • Journal Article
      Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice
      Li L, Hernandez CC, Gimenez LE, Xu B, Dahir NS, Peisley A, Wu Z, Chen M, Serrato A, Wan R, Swati , Birnbaum SG, Cone RD, Liu C. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-026-76561-w
      PMID: 42693128
    • Journal Article
      Structural and Functional Studies of Inward Rectifier Kir7.1 and its Regulation by the Melanocortin-4 Receptor
      Peisley A. Nature Communications, 2026 Jul 2;
    • Journal Article
      Attractin-like protein 1 is an essential partner of MC4R to regulate body weight
      Buscaglia P, Bowman KR, Lawler K, Hernandez CC, Scotucci J, Bounds R, Keogh JM, Henning E, Cone RD, Farooqi IS, Sebag JA. Nature Communications, 2026 Sep 23; DOI:10.1038/s41467-026-77897-z
    • Preprint
      Attractin-Like Protein 1 (ATRNL1): An Essential Partner of MC4R to Regulate Body Weight
      Buscaglia P, Bowman KR, Lawler K, Hernandez CC, Scotucci J, Bounds R, Keogh JM, Henning E, Cone RD, Farooqi IS, Sebag JA. 2026 Jan 19; medRxiv, DOI:10.64898/2026.01.12.26343722
    • Journal Article
      MON-677 Role Of The Melanocortin-3 Receptor In Regulation Of Lean Mass, Muscle Function, And Exercise-induced Hyperphagia
      Danjo ND, da Silva AC, Cone RD. Journal of the Endocrine Society, 2025 Oct 24; 9 (Supplement_1): bvaf149.017 DOI:10.1210/jendso/bvaf149.017
      PMID: PMC12544962
    • Journal Article
      Melanocortin receptors in GtoPdb v.2025.3
      Caruso V, Tatro JB, Schiöth H, Pouton C, Mountjoy KG, Hruby VJ, Haskell-Luevano C, Gantz I, Fong TM, Farooqi S, Eberle AN, Cone RD, Clark AJL, Chai B-X, Wikberg JES. IUPHAR/BPS Guide to Pharmacology CITE, 2025 Oct 20; 2025 (3): DOI:10.2218/gtopdb/f38/2025.3
    • Journal Article
      An Improved Synthesis of Compound 11, a Unique Bicyclic Melanocortin-3 Antagonist
      Joy ST, Dahir NS, Cone RD, Mapp AK. Peptide Science, 2025 Jan 1; 117 (1): DOI:10.1002/pep2.24385
    • Journal Article
      Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis
      Lu ZA, Ploner A, Birgegård A, Adan R, Alfredsson L, Ando T, Andreassen O, Baker J, Bergen A, Berrettini W, Boden J, Boehm I, Perica VB, Brandt H, Breen G, Bryois J, Buehren K, Bulik C, Burghardt R, Cassina M, Cichon S, Coleman J, Cone R, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, De Zwaan M, Dedoussis G, Desocio J, Dick D, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan L, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fischer K, Föcker M, Foretova L, Forstner A, Forzan M, Franklin C, Gallinger S, Giegling I, Giusti-Rodríguez P, Gonidakis F, Gordon S, Gorwood P, Mayora MG, Grove J, Guillaume S, Guo Y, Hakonarson H, Halmi K, Hanscombe K, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Herms S, Herpertz-Dahlmann B, Herzog W, Hinney A, Horwood LJ, Hübel C, Huckins L, Hudson J, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kalsi G, Kaminská D, Kaplan A, Kaprio J, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy J, Kennedy M, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klareskog L, Klump K. Schizophrenia Bulletin, 2024 Sep 1; 50 (5): 1255 - 1265. DOI:10.1093/schbul/sbae087
      PMID: 38848516

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    In the U.S., dietary obesity has a prevalence of 40% and obesity increases the risk of other chronic diseases such as heart disease and diabetes. Even though anorexia nervosa has a prevalence of 1%, it is the second-highest death rate of any mental illness. Roger Cone discusses how melanocortin receptors can be used to treat both obesity and anorexia.
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