Lei Yin, MD, PhD

 labcoat
Professor of Molecular and Integrative Physiology and Professor of Internal Medicine, Medical School
[email protected]
Available to mentor
Lei Yin, MD, PhD
labcoat
Professor
  • Center Memberships
  • Recent Publications

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    • Center Memberships
    • Center Member
      Caswell Diabetes Institute

    Recent Publications

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    • Journal Article
      The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress Response
      Zhao Y, Wang S, Zhang J, Cooke S, Zhang G, Zhao Z, Oh J, Tong X, Yin L. FASEB Journal, 2026 May 15; 40 (9): DOI:10.1096/fj.202600106R
      PMID: 42051137
    • Journal Article
      The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification
      Kim H, Thepsuwan P, Wei J, Ju D, Chen Q, Zhang X, Li L, Xu J, Tong X, Sun S, He C, Yin L, Fang D, Zhang K. Science Signaling, 2026 Jan 6; 19 (919): DOI:10.1126/scisignal.adx8300
      PMID: 41493974
    • Journal Article
      The Non-Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF-β-E2F1 Axis
      Zhang J, Zhao Y, Pulivendala G, Zhang Q, Rui L, Gao J, Wang H, Zhang G, Nuotio-Antar A, Tong X, Yin L. Advanced Science, 2025 Aug 7; 12 (29): DOI:10.1002/advs.202415032
      PMID: 40548862
    • Journal Article
      OPN-Mediated Crosstalk Between Hepatocyte E4BP4 and Hepatic Stellate Cells Promotes MASH-Associated Liver Fibrosis.
      Wang S, Gao J, Yang M, Zhang G, Yin L, Tong X. Adv Sci (Weinh), 2024 Dec; 11 (47): e2405678 DOI:10.1002/advs.202405678
      PMID: PMC11653607
    • Journal Article
      Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH
      Zhang D, Zhao Y, Zhang G, Lank D, Cooke S, Wang S, Nuotio-Antar A, Tong X, Yin L. Molecular Metabolism, 2024 Jul 1; 85: DOI:10.1016/j.molmet.2024.101957
      PMID: 38740087
    • Proceeding / Abstract / Poster
      Activation of Hepatocyte E4BP4-OPN Axis Promotes Live Fibrosis in Non-alcoholic Steatohepatitis.
      Gao J, Wang S, Yang M, Zhang G, Cooke S, Yin L, Tong X. 2024 Mar 3;
    • Presentation
      Noncanonical Actions of ChREBP∝ in Diet-Induced Liver Fibrosis.
      Yin L. 2024 Jun 7;
    • Presentation
      Noncanonical Actions of ChREBP∝ in Diet-Induced Liver Fibrosis.
      Yin L. 2024 Jun 7;