Robert T Kennedy
Hobart H Willard Distinguished University Professor of Chemistry
Professor of Chemistry
College of Literature, Science, and the Arts
Professor of Pharmacology
[email protected]

Available to mentor

Robert T Kennedy
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Robert Kennedy is a Professor of Chemistry and Pharmacology. His research interests are in bioanalytical chemistry with an emphasis on microfluidics, mass spectrometry, chromatography, and electrophoresis. He develops these methods to study neurotransmitter dynamics in vivo, hormone secretion, and for high-throughput experimentation.

    Links
    • My Background
    Qualifications
    • PhD
      University of North Carolina-Chapel Hill, United States, 1988
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    We develop and apply bioanalytical methods for studying hormone and neurtransmitter secretion. We develop microfluidic chips to culture cells and integrate methods to measure releasate. We also coupling sampling probes to analytical methods for in vivo brain chemical measurements. We develop metabolomics methods for studying biological systems. We have focused LC-MS/MS, capillary electrophoresis, and sensors for analysis. We have applied to study of islets of Langerhans and various rodent models in the brain.

    Recent Publications See All Publications
    • Journal Article
      In-Depth Chemical Analysis of the Brain Extracellular Space Using In Vivo Microdialysis with Liquid Chromatography-Tandem Mass Spectrometry.
      Anderson BG, Popov P, Cicali AR, Nwamba A, Evans CR, Kennedy RT. Anal Chem, 2024 Oct 3; DOI:10.1021/acs.analchem.4c03806
      PMID: 39360623
    • Journal Article
      Conserved 5-methyluridine tRNA modification modulates ribosome translocation.
      Jones JD, Franco MK, Giles RN, Eyler DE, Tardu M, Smith TJ, Snyder LR, Polikanov YS, Kennedy RT, Niederer RO, Koutmou KS. Proc Natl Acad Sci U S A, 2024 Aug 27; 121 (35): e2401743121 DOI:10.1073/pnas.2401743121
      PMID: 39159370
    • Journal Article
      Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.
      Jun H, Liu S, Knights AJ, Zhu K, Ma Y, Gong J, Lenhart AE, Peng X, Huang Y, Ginder JP, Downie CH, Ramos ET, Kullander K, Kennedy RT, Xu XZS, Wu J. PLoS Biol, 2024 Jul; 22 (7): e3002728 DOI:10.1371/journal.pbio.3002728
      PMID: 39028754
    • Journal Article
      Offline Two-Dimensional Liquid Chromatography-Mass Spectrometry for Deep Annotation of the Fecal Metabolome Following Fecal Microbiota Transplantation.
      Anderson BG, Raskind A, Hissong R, Dougherty MK, McGill SK, Gulati AS, Theriot CM, Kennedy RT, Evans CR. J Proteome Res, 2024 Jun 7; 23 (6): 2000 - 2012. DOI:10.1021/acs.jproteome.4c00022
      PMID: 38752739
    • Journal Article
      Preparation of high-efficiency HILIC capillary columns utilizing slurry packing at 2100 bar.
      Anderson BG, Hancock TA, Kennedy RT. J Chromatogr A, 2024 May 10; 1722: 464856 DOI:10.1016/j.chroma.2024.464856
      PMID: 38579610
    • Journal Article
      Systematic evaluation of benzoylation for liquid chromatography-mass spectrometry analysis of different analyte classes.
      Lenhart AE, Booth P-PM, Simcox KM, Ramos BA, Kennedy RT. J Chromatogr A, 2024 May 10; 1722: 464872 DOI:10.1016/j.chroma.2024.464872
      PMID: 38581975
    • Preprint
      Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-dimethyltryptamine in Rats.
      Glynos NG, Huels ER, Nelson A, Kim Y, Kennedy RT, Mashour GA, Pal D. 2024 Apr 22; DOI:10.1101/2024.04.19.589047
      PMID: 38712161
    • Journal Article
      Cyclic Ion Mobility-Mass Spectrometry and Tandem Collision Induced Unfolding for Quantification of Elusive Protein Biomarkers.
      Makey DM, Gadkari VV, Kennedy RT, Ruotolo BT. Anal Chem, 2024 Apr 16; 96 (15): 6021 - 6029. DOI:10.1021/acs.analchem.4c00477
      PMID: 38557001