Peter Arvan
William K and Delores S Brehm Professor of Type 1 Diabetes Research
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
Medical School
Available to mentor
Peter Arvan
Professor
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Qualifications
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MD, PhDYale University School of Medicine, New Haven, CT, United States
1977 - 1984
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ABCornell University, Ithaca, NY, United States
1977 - 1981
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberBiosciences Initiative
Recent Publications
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Jang I, Duffey A, Itkin-Ansari P, Arvan P, Kaufman RJ. Proceedings of the National Academy of Sciences of the United States of America, 2026 Jun 9; 123 (23): e2533617123Journal ArticleCoordinated expression and assembly of BiP, p58IPK, and ER chaperone complexes maximize proinsulin folding in pancreatic β cells
DOI:10.1073/pnas.2533617123 PMID: 42224595 -
Young C, Arvan P. FASEB J, 2026 Apr 30; 40 (8): e71801Journal ArticleSubstrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology.
DOI:10.1096/fj.202600673R PMID: PMC13078365 -
Young C, Zhang X, Kellogg AP, Fonseca TL, Pena K, Beyzin A, Liao X-H, Cicatiello AG, Zhang H, Bianco AC, Refetoff S, Arvan P. Thyroid, 2026 Mar 9; 10507256261429120Journal ArticleThyroid Hormone Synthesis Without Thyroglobulin.
DOI:10.1177/10507256261429120 PMID: 41801750 -
Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB. Nat Commun, 2026 Feb 25;Journal ArticleSEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
DOI:10.1038/s41467-026-69928-6 PMID: 41741474 -
Young C, Zhang X, Wang X, Kellogg AP, Pena K, Cumming AZ, Liao XH, Larkin D, Zhang H, Mastroianni E, Grasberger H, Refetoff S, Arvan P. Journal of Clinical Investigation, 2026 Feb 2; 136 (3): 1 - 11.Journal ArticleStimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress
DOI:10.1172/JCI204387 -
Arunagiri A, Haataja L, Alam M, Gleason NF, Mastroianni E, Cheng CY, Bazzi S, Knupp J, Metawea I, Hassan A, Larkin D, Fang D, Tsai B, Qi L, Arvan P. Journal of Clinical Investigation, 2026 Jan 16; 136 (2):Journal ArticleLimiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis
DOI:10.1172/JCI188888 PMID: 41129238 -
Tong Y, Becker M, Schierloh U, Natividade da Silva F, Haataja L, Cai Y, Patel KA, Kobaisi F, Mirshahi UL, Colclough K, Javed MS, Wakeling MN, Fantuzzi F, Lytrivi M, Sawatani T, Arroyo MN, Yi X, Vinci C, Montaser H, Pachera N, Otonkoski T, Igoillo-Esteve M, Scharfmann R, Hattersley AT, Arvan P, De Beaufort C, Cnop M. EMBO Molecular Medicine, 2026 Jan 1;Journal ArticleA new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data
DOI:10.1038/s44321-025-00362-9 PMID: 41484206 -
Shao R, Alam M, Haataja L, Arvan P. International Journal of Molecular Sciences, 2026 Jan 1; 27 (1):Journal ArticleStructural Communication Between C-Peptide and Insulin Within the Proinsulin Molecule
DOI:10.3390/ijms27010483 PMID: 41516356
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