Peter Arvan
William K and Delores S Brehm Professor of Type 1 Diabetes Research
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
Medical School
Available to mentor
Peter Arvan
Professor
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Qualifications
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MD, PhDYale University School of Medicine, New Haven, CT, United States
1977 - 1984
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ABCornell University, Ithaca, NY, United States
1977 - 1981
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberBiosciences Initiative
Recent Publications
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Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleSEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
DOI:10.1038/s41467-026-69928-6 PMID: 41741474 -
Ruan Y, Gleason NF, Arvan P. Cells, 2026 Sep 2; 15 (17): 1584 - 1584.Journal ArticleBeta Cell Proinsulin Response to Amino Acid Availability
DOI:10.3390/cells15171584 -
Jang I, Duffey A, Itkin-Ansari P, Arvan P, Kaufman RJ. Proceedings of the National Academy of Sciences of the United States of America, 2026 Jun 9; 123 (23):Journal ArticleCoordinated expression and assembly of BiP, p58IPK, and ER chaperone complexes maximize proinsulin folding in pancreatic β cells
DOI:10.1073/pnas.2533617123 PMID: 42224595 -
Young C, Arvan P. FASEB Journal, 2026 Apr 30; 40 (8):Journal ArticleSubstrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
DOI:10.1096/fj.202600673R PMID: 41979536 -
Young C, Zhang X, Kellogg AP, Fonseca TL, Pena K, Beyzin A, Liao XH, Cicatiello AG, Zhang H, Bianco AC, Refetoff S, Arvan P. Thyroid Official Journal of the American Thyroid Association, 2026 Apr 1; 36 (4): 441 - 450.Journal ArticleThyroid Hormone Synthesis Without Thyroglobulin
DOI:10.1177/10507256261429120 PMID: 41801750 -
Tong Y, Becker M, Schierloh U, Natividade da Silva F, Haataja L, Cai Y, Patel KA, Kobaisi F, Mirshahi UL, Colclough K, Javed MS, Wakeling MN, Fantuzzi F, Lytrivi M, Sawatani T, Arroyo MN, Yi X, Vinci C, Montaser H, Pachera N, Otonkoski T, Igoillo-Esteve M, Scharfmann R, Hattersley AT, Arvan P, De Beaufort C, Cnop M. EMBO Molecular Medicine, 2026 Feb 13; 18 (2): 620 - 645.Journal ArticleA new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data
DOI:10.1038/s44321-025-00362-9 PMID: 41484206 -
Young C, Zhang X, Wang X, Kellogg AP, Pena K, Cumming AZ, Liao XH, Larkin D, Zhang H, Mastroianni E, Grasberger H, Refetoff S, Arvan P. Journal of Clinical Investigation, 2026 Feb 2; 136 (3): 1 - 11.Journal ArticleStimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress
DOI:10.1172/JCI204387 PMID: 41623171 -
Arunagiri A, Haataja L, Alam M, Gleason NF, Mastroianni E, Cheng CY, Bazzi S, Knupp J, Metawea I, Hassan A, Larkin D, Fang D, Tsai B, Qi L, Arvan P. Journal of Clinical Investigation, 2026 Jan 16; 136 (2):Journal ArticleLimiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis
DOI:10.1172/JCI188888 PMID: 41129238
Featured News & Stories
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Rugiero Promise Foundation celebrates 15 years of championing diabetes research
Annual fundraiser advances diabetes research at U-M while honoring the memory of Antonio Rugiero.
