David P Olson, MD, PhD
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About
Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core.
Qualifications
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FellowBoston Children's Hospital, Pediatrics, Boston, United States
2002 - 2005
Other
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ResidentBoston Children's Hospital, Pediatrics, Boston, United States
1999 - 2002
Residency
Center Memberships
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Center MemberCaswell Diabetes Institute
Research Overview
The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.
Recent Publications
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Waselewski AC, Walsh LM, Holste KG, Olson DP, Garton HJL. Journal of Clinical Endocrinology and Metabolism, 2026 Jul 1; 111 (7): e1848 - e1854.Journal ArticleNatural history of pituitary incidentalomas in pediatric patients: a single-center, retrospective analysis
DOI:10.1210/clinem/dgag047 PMID: 41637571 -
Dell'Orco J, Pan W, Allison MB, Tomlinson AJ, Wean J, Sabatini PV, Rhodes CJ, Olson DP, Myers MG, Goforth PB. Molecular Metabolism, 2026 Jun 1; 108:Journal ArticleIncreased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity
DOI:10.1016/j.molmet.2026.102378 PMID: 42082152 -
Duensing AM, Belmont-Rausch D, Tomlinson AJ, Crowley A, Sass F, Heaton E, Coester B, Brown JM, Hassan S, Wu Z, Qi N, Olson DP, Sabatini PV, Myers MG, Pers TH. 2026 Mar 26;PreprintMolecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure.
DOI:10.64898/2026.03.26.714551 PMID: 41929005 -
Sutton Hickey AK, Gonzalez IE, Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, Olson DP. Scientific Reports, 2025 Dec 1; 15 (1):Journal ArticleAuthor Correction: Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance (Scientific Reports, (2020), 10, 1, (5546), 10.1038/s41598-020-62468-z)
DOI:10.1038/s41598-025-85804-7 PMID: 39966516 -
Citterio CE, Morales-Rodriguez B, Liao XH, Vu C, Nguyen R, Tsai J, Le J, Metawea I, Liu M, Olson DP, Refetoff S, Arvan P. Journal of the Endocrine Society, 2025 Oct 24; 9 (Supplement_1): bvaf149.2308Journal ArticleSAT-393 Physiology Of A Thyroidally-Derived T3-Centric Hormonal Environment
DOI:10.1210/jendso/bvaf149.2308 PMID: PMC12543744 -
Citterio CE, Morales-Rodriguez B, Liao XH, Vu C, Nguyen R, Tsai J, Le J, Metawea I, Liu M, Olson DP, Refetoff S, Arvan P. International Journal of Molecular Sciences, 2025 Aug 1; 26 (15):Journal ArticleA Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion
DOI:10.3390/ijms26157166 PMID: 40806299 -
Leon-Mercado L, Menendez-Montes I, Tao J, Chen B, Olson DP, Mackaaij C, Cleypool CGJ, Gautron L. Molecular Metabolism, 2025 Feb 1; 92:Journal ArticleHypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body
DOI:10.1016/j.molmet.2025.102095 PMID: 39793758 -
Wang Y, Qiu W, Kernodle S, Parker C, Padilla MA, Su J, Tomlinson AJ, Oldham S, Field J, Bernard E, Hornigold D, Rhodes CJ, Olson DP, Seeley RJ, Myers MG. Molecular Metabolism, 2025 Feb 1; 92:Journal ArticleRoles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP
DOI:10.1016/j.molmet.2024.102093 PMID: 39755369
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