David P Olson, MD, PhD

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David Murray Cowie M.D. Research Professor of Pediatrics
Professor of Pediatrics
Professor of Molecular and Integrative Physiology
Medical School
Available to mentor
David P Olson, MD, PhD
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Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core.

    Qualifications

    • Fellow
      Boston Children's Hospital, Pediatrics, Boston, United States
      2002 - 2005
      Other
    • Resident
      Boston Children's Hospital, Pediatrics, Boston, United States
      1999 - 2002
      Residency

    Center Memberships

    • Center Member
      Caswell Diabetes Institute

    Research Overview

    The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.

    Recent Publications

    See All Publications
    • Journal Article
      Natural history of pituitary incidentalomas in pediatric patients: a single-center, retrospective analysis
      Waselewski AC, Walsh LM, Holste KG, Olson DP, Garton HJL. Journal of Clinical Endocrinology and Metabolism, 2026 Jul 1; 111 (7): e1848 - e1854. DOI:10.1210/clinem/dgag047
      PMID: 41637571
    • Journal Article
      Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity
      Dell'Orco J, Pan W, Allison MB, Tomlinson AJ, Wean J, Sabatini PV, Rhodes CJ, Olson DP, Myers MG, Goforth PB. Molecular Metabolism, 2026 Jun 1; 108: DOI:10.1016/j.molmet.2026.102378
      PMID: 42082152
    • Preprint
      Molecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure.
      Duensing AM, Belmont-Rausch D, Tomlinson AJ, Crowley A, Sass F, Heaton E, Coester B, Brown JM, Hassan S, Wu Z, Qi N, Olson DP, Sabatini PV, Myers MG, Pers TH. 2026 Mar 26; DOI:10.64898/2026.03.26.714551
      PMID: 41929005
    • Journal Article
      Author Correction: Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance (Scientific Reports, (2020), 10, 1, (5546), 10.1038/s41598-020-62468-z)
      Sutton Hickey AK, Gonzalez IE, Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, Olson DP. Scientific Reports, 2025 Dec 1; 15 (1): DOI:10.1038/s41598-025-85804-7
      PMID: 39966516
    • Journal Article
      SAT-393 Physiology Of A Thyroidally-Derived T3-Centric Hormonal Environment
      Citterio CE, Morales-Rodriguez B, Liao XH, Vu C, Nguyen R, Tsai J, Le J, Metawea I, Liu M, Olson DP, Refetoff S, Arvan P. Journal of the Endocrine Society, 2025 Oct 24; 9 (Supplement_1): bvaf149.2308 DOI:10.1210/jendso/bvaf149.2308
      PMID: PMC12543744
    • Journal Article
      A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion
      Citterio CE, Morales-Rodriguez B, Liao XH, Vu C, Nguyen R, Tsai J, Le J, Metawea I, Liu M, Olson DP, Refetoff S, Arvan P. International Journal of Molecular Sciences, 2025 Aug 1; 26 (15): DOI:10.3390/ijms26157166
      PMID: 40806299
    • Journal Article
      Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body
      Leon-Mercado L, Menendez-Montes I, Tao J, Chen B, Olson DP, Mackaaij C, Cleypool CGJ, Gautron L. Molecular Metabolism, 2025 Feb 1; 92: DOI:10.1016/j.molmet.2025.102095
      PMID: 39793758
    • Journal Article
      Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP
      Wang Y, Qiu W, Kernodle S, Parker C, Padilla MA, Su J, Tomlinson AJ, Oldham S, Field J, Bernard E, Hornigold D, Rhodes CJ, Olson DP, Seeley RJ, Myers MG. Molecular Metabolism, 2025 Feb 1; 92: DOI:10.1016/j.molmet.2024.102093
      PMID: 39755369

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