Matthew T Patrick, PhD, MEng
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About
Matthew Patrick, MEng, PhD is a Research Assistant Professor of Dermatology at the University of Michigan Medical School, and is a member of the Cutaneous Bioinformatics Research Program. Dr. Patrick is pursuing research focused upon translational bioinformatics, particularly on providing biological inference from high dimensional data for dermatological research.
Dr. Patrick received his PhD in Computer Science from University of York in the United Kingdom in 2013. He completed postdoctoral research training in Epidemiology and Modelling at the University of Cambridge before joining the U-M Department of Dermatology in 2016 as a postdoctoral research fellow working with Dr. Lam C. (Alex) Tsoi in the Cutaneous Bioinformatics Program. He joined the U-M Department of Dermatology faculty in 2020.
Qualifications
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PhD in Computer ScienceDepartment of Computer Science, University of York, York, United Kingdom
2009 - 2014
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MEng in Computer Systems and Software EngineeringDepartment of Computer Science, University of York, United Kingdom
2004 - 2009
Center Memberships
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Center MemberAI and Digital Health Innovation
Research Overview
- Applying mathematical, statistical and computational approaches to understand the behaviours of complex systems.
- Using advanced machine learning and optimisation techniques to address challenging problems.
- Testing and evaluating the implications of data and software quality for scientific research.
Recent Publications
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Zhou R, Chaskar P, Patrick MT, Wang K, Piketty C, Julia V, Gudjonsson JE, Krishnaswamy JK, Tsoi LC. Journal of Investigative Dermatology, 2026 Jan 1; 146 (1): 283 - 287.e11.Journal ArticleNemolizumab Treatment Normalizes Dysregulated Microbiome in Lesional Prurigo Nodularis
DOI:10.1016/j.jid.2025.06.1575 PMID: 40571154 -
Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z, Siebert S, Schofield J, McAteer H, Brown SJ, Smith CH, Burden AD, Nelis M, Milani L, Metspalu A, Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleGWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
DOI:10.1038/s41467-025-56719-8 PMID: 40021644 -
Wu Y, Bogle R, Patrick MT, Mehrnaz GK, Xing X, Billi AC, Kahlenberg JM, Julia V, Gudjonsson JE, Tsoi LC. Journal of Allergy and Clinical Immunology, 2025 Dec 1; 156 (6): 1588 - 1599.Journal ArticleIdentification of disease-specific regulatory networks in prurigo nodularis versus atopic dermatitis through ATAC/RNA single-nucleus profiling
DOI:10.1016/j.jaci.2025.08.026 PMID: 40939757 -
Oliva M, Sarkar MK, March ME, Saeidian AH, Mentch FD, Hsieh CL, Tang F, Uppala R, Patrick MT, Li Q, Bogle R, Kahlenberg JM, Watson D, Glessner JT, Youssefian L, Vahidnezhad H, Tsoi LC, Hakonarson H, Gudjonsson JE, Smith KM, Riley-Gillis B. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleIntegration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
DOI:10.1038/s41467-025-58310-7 PMID: 40164604 -
Jiang R, Bogle R, Fox J, Gharaee-Kermani M, Qin T, Patrick MT, Cai Y, Xing X, Maverakis E, Waterworth D, Cuff C, Miller LS, Sabins N, Polak ME, Tsoi LC, Gudjonsson JE, Billi AC. Journal of Investigative Dermatology, 2025 Nov 11; 145 (11): e66Proceeding / Abstract / Poster224 Dendritic cell subsets drive Th2-mediated inflammation in atopic dermatitis via galectin-9, MIF, and CCL pathways
DOI:10.1016/j.jid.2025.09.228 -
Patrick M, Wu Y, Zhong X, Li Q, Julia V, Li B, Gudjonsson JE, Tsoi LC. Journal of Investigative Dermatology, 2025 Nov 11; 145 (11): e37Proceeding / Abstract / Poster37 Prurigo Nodularis Genetic Association Identifies a Genome-Wide Signal at IL31
DOI:10.1016/j.jid.2025.09.055 -
Patrick MT, Wu Y, Zhong X, Li Q, Julia V, Li B, Gudjonsson JE, Tsoi LC. Journal of Allergy and Clinical Immunology, 2025 Nov 1; 156 (5): 1410 - 1413.Journal ArticleIL31 identified as a key genetic risk factor for prurigo nodularis
DOI:10.1016/j.jaci.2025.06.031 PMID: 40651664 -
Shaked G, Zhang H, Zhang Z, Zhou J, Gudjonsson JE, Elder JT, Patrick MT, Tsoi LC. Nar Genomics and Bioinformatics, 2025 Sep 1; 7 (3):Journal ArticleLoopsim: enrichment analysis of chromosome conformation capture with fast empirical distribution simulation
DOI:10.1093/nargab/lqaf098
