Rachel Leigh Byerley Reinert
Assistant Professor of Internal Medicine
Medical School
University of Michigan
Internal Medicine, Division of Metabolism, Endocrinology & Diabetes
1000 Wall Street, 5132 Brehm Tower
Ann Arbor, MI 48105
[email protected]
Internal Medicine, Division of Metabolism, Endocrinology & Diabetes
1000 Wall Street, 5132 Brehm Tower
Ann Arbor, MI 48105
Available to mentor
Rachel Leigh Byerley Reinert
Assistant Professor
Manage Your Profile
Qualifications
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FellowshipUniversity of Michigan, Internal Medicine; Division of Metabolism, Endocrinology & Diabetes, Ann Arbor, MI, United States
2016 - 2019
Postdoctoral Fellowship
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ResidencyUniversity of Michigan, Internal Medicine, Ann Arbor, MI, United States
2017 - 2019
Residency
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MDVanderbilt University School of Medicine, 2201 West End, Nashville, TN, 37235, United States
2005 - 2014
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PhDVanderbilt University, Medical Scientist Training Program, 2201 West End, Nashville, TN, 37235, United States
2007 - 2012
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BSUniversity of Southern Indiana, Evansville, IN, United States
2001 - 2005
Center Memberships
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Center MemberCaswell Diabetes Institute
Research Overview
Pancreatic islet cells are responsible for synthesizing, packaging, and secreting glucose-regulating hormones, including insulin and glucagon. Disruption of these processes contributes to hyperglycemia in diabetes mellitus. My laboratory group studies how cellular protein quality control mechanisms regulate hormone processing and define islet cell function.
Links
Recent Publications
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Reinert RB, Cai Q, Hong J-Y, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CVE, Brissova M, Powers AC. Development, 2014 Apr; 141 (7): 1480 - 1491.Journal ArticleVascular endothelial growth factor coordinates islet innervation via vascular scaffolding.
DOI:10.1242/dev.098657 PMID: PMC3957372 -
Reinert RB, Kantz J, Misfeldt AA, Poffenberger G, Gannon M, Brissova M, Powers AC. PLoS ONE, 2012 Mar 28; 7 (3):Journal ArticleTamoxifen-induced cre-loxp recombination is prolonged in pancreatic islets of adult mice
DOI:10.1371/journal.pone.0033529 PMID: 22470452 -
Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ. Diabetes, 2010 Dec 1; 59 (12): 3090 - 3098.Journal ArticleConditional gene targeting in mouse pancreatic β-cells: Analysis of ectopic cre transgene expression in the brain
DOI:10.2337/db10-0624 PMID: 20802254 -
Gillespie L, Reinert R, Chase C, Gelick B, Thomas I, Oral E, Philipson L, Broome D. Journal of the Endocrine Society, 2026 Jun 14;Proceeding / Abstract / PosterSUN-548 Dual GIP/GLP-1 Receptor Agonist Use in PDX1-MODY: A Case Report.
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Mathew A, Kinger K, Esfandiari N, Reinert R, Saberi, MD S. 2026 Jun 14;Proceeding / Abstract / PosterUnraveling Hypercalcemia in Metastatic Esophageal Adenocarcinoma: Dual Pathogenic Mechanisms Beyond Elevated Parathyroid Hormone
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Reinert R. 2026 Jun 9;PresentationProtein Quality Control Determines Pancreatic Islet Alpha Cell Function and Survival
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Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB. Nat Commun, 2026 Feb 25; 17 (1):Journal ArticleSEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
DOI:10.1038/s41467-026-69928-6 PMID: PMC13057016 -
Reinert R. 2025 Aug 31;PresentationProtein Quality Control Determines Pancreatic Islet Alpha Cell Function and Survival
Featured News & Stories
Department News
Brigid Gregg, MD, set to lead pediatric endocrinology at University of Wisconsin-Madison
Brigid Gregg, MD, Associate Director of Enrichment Programs for the Caswell Diabetes Institute set to become the new Chief of the Division of Pediatric Endocrinology at the University of Wisconsin-Madison.
Health Lab
Using genetic testing, doctors help patient find answers for her diabetes
For 30 years Autumn Caris thought she had type 1 diabetes. After learning about MODY, a rare and often misdiagnosed type of diabetes, she finally got answers at U-M.
