Prabesh Kanel, PhD

 Prabesh Kanel
Research Assistant Professor
Radiology
Medical School
University of Michigan Medical School
Radiology
24 Frank Lloyd Wright Dr, Lobby B, Rm 100
Ann Arbor, Michigan 48105
[email protected]
Available to mentor
Prabesh Kanel, PhD
Prabesh Kanel
Research Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    I am a research faculty interested in research that uses magnetic resonance imaging (MRI) and positron emission tomography (PET) in studies involving neurodegenerative disorders, with a particular focus on Parkinson's disease and related disorders. I am also keen on exploring the application of machine learning methods to analyze imaging data sets combining different imaging modalities. My global health efforts focus is on improving the lives of people with Parkinsonism worldwide, particularly in low- and middle-income countries, by strengthening diagnosis, treatment, and care, while also driving research and innovation to ultimately prevent and better understand this disorder.

    Qualifications
    • Postdoctoral Research Fellow
      University of Michigan, Radiology, Ann Arbor, United States
      2017 - 2020
      Postdoctoral Fellowship

    Center Memberships
    • Center Member
      Global REACH

    Research Overview

    Machine Learning and its applications in Neuroimaging
    Aging, Parkinson’s disease, Progressive Supranuclear Palsy and related disorders

    Recent Publications

     See All Publications
    • Journal Article
      Cholinergic system changes in levodopa-unresponsive freezing of gait and failure of goal-directed motor behavior in Parkinson's disease.
      Bohnen NI, Roytman S, Carli G, Chou KL, Kanel P, Albin RL. Neural Regen Res, 2026 Jun 8; DOI:10.4103/NRR.NRR-D-25-01957
    • Journal Article
      White matter lesions disrupt cholinergic pathways important for cognition in Parkinson's disease.
      Carli G, Brown T, Michalakis F, Biddix A, Roytman S, Vangel R, Van Hout A, Kanel P, Scott P, Albin RL, Bohnen NI. Brain, 2026 May 12; DOI:10.1093/brain/awag172
      PMID: 42117428
    • Journal Article
      Genome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology
      Step K, Hernández CF, Khani M, Eltaraifee E, Hernández-Medrano AJ, Kung PJ, Ostrožovičová M, Zirra A, Pérez-Palma E, Mencacci NE, Keller Sarmiento IJ, Morris HR, Mata IF, Acosta-Uribe J, Fang ZH, Bandres-Ciga S, Mecheri Y, Sofiane BM, Traki B, Gatto EM, Kauffman M, Capparelli F, Muller MV, Tela MS, Adamec DS, Avila C, Khachatryan S, Tavadyan Z, Isayan M, Shepherd C, Kumar K, Ellis M, Rentería M, Koks S, Rowel S, Yeow D, Sue C, Ocampo V, Wools C, Weiss KA, Siow SF, Davis R, Willis A, He S, Wilcox RA, Howting D, Price JD, Cheong PL, Tchan M, Young MA, Mclean C, Martin N, Briceño HM, Kimber T, Wu K, O'Sullivan J, Singleton L, Rudaks LI, García-Marín L, Zimprich A, Jafarov K, Ceferov K, Sarker I, Crosiers D, Schumacher-Schuh A, Rieder C, Awad P, Tumas V, Camargos S, Costa L, Neto P, Monchi O, Fon E, Thibault R, Gan-Or Z, Teferra M, Lang A, Senkevich K, Miranda M, Bustamante M, Nuñez J, Lucero B, Colombo A, Personal MT, Palma E, Chana-Cuevas P, Cortes ABM, Pinto MEC, Canals F, Galleguillos B, Aguilera PAO, Fernandez-Toledo E, Tang B, Shang H, Guo J, Chan P, Luo W, Liu Z, Chan G. Movement Disorders, 2026 May 1; 41 (5): 1128 - 1140. DOI:10.1002/mds.70182
      PMID: 41808632
    • Journal Article
      Asymmetric Cholinergic Basal Forebrain Atrophy Marks Freezing of Gait in Parkinson's Disease.
      Craig CE, Kanel P, Ray NJ, Bohnen NI. Eur J Neurosci, 2026 Mar; 63 (6): e70467 DOI:10.1111/ejn.70467
      PMID: PMC13006747
    • Journal Article
      Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution In Vivo MRI From the Hippocampal Subfields Group (HSG)
      Daugherty AM, Carr V, Canada KL, Rådman G, Brown T, Augustinack J, Amunts K, Bakker A, Berron D, Burggren A, Chetelat G, de Flores R, Ding SL, Huang Y, Johnson E, Kanel P, Keresztes A, Kedo O, Kennedy KM, Lee J, Malykhin N, Martinez A, Mueller S, Mulligan E, Ofen N, Palombo D, Pasquini L, Pluta J, Raz N, Riggins T, Rodrigue KM, Saifullah S, Schlichting ML, Stark C, Wang L, Yushkevich P, La Joie R, Wisse L, Olsen R. Hippocampus, 2026 Mar 1; 36 (2): DOI:10.1002/hipo.70073
      PMID: 41635209
    • Preprint
      Cholinergic substrates of gait and postural impairments in Progressive Supranuclear Palsy
      Kanel P, Carli G, Roytman S, Zee SVD, Vangel R, Barr J, Brown T, Spears CC, Narkis A, Slingerland S, Meles S, Laar TV, Scott PJH, Albin RL, Bohnen NI. 2026 Feb 4; Springer Science and Business Media LLC, DOI:10.21203/rs.3.rs-8778777/v1
    • Journal Article
      Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease
      Brown T, Carli G, Kanel P, Roytman S, Barr J, Bohnen NI, Albin RL. Annals of Clinical and Translational Neurology, 2026 Jan 1; DOI:10.1002/acn3.70335
    • Journal Article
      Excessive GABAergic activity in striatal and frontal cortical regions more than dopaminergic functions are related to daytime sleepiness in Parkinson's disease: An exploratory 11C-flumazenil PET study.
      Vangel R, Roytman S, Reddy M, Van Hout A, Beaulieu ML, Carli G, Scott PJH, Kanel P, Bohnen NI. Geromedicine, 2026 2 (3): DOI:10.70401/geromedicine.2026.0025
      PMID: PMC13251600