Lam (Alex) C Tsoi, PhD
Associate Professor of Dermatology
Associate Professor of Computational Medicine and Bioinformatics
Research Associate Professor
Mary H Weiser Food Allergy
Medical School and Research Associate Professor, Biostatistics
School of Public Health
Email:
[email protected]
Phone:
Available to mentor
Lam (Alex) C Tsoi, PhD
Associate Professor
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About
My research focuses on identifying the genetic and genomic components for psoriasis, and understanding their biological effect and contribution to disease heterogeneity. I currently direct the Center for Cutaneous Bioinformatics at the University of Michigan, and I am the associate director of the Functional Analytic Core of the P30-funded University of Michigan Skin Biology Disease and Resource Center.
I have been actively involved in coordinating and conducting different genetic and genomic studies to understand the pathophysiology of different immune-mediated disorders including psoriasis, psoriatic arthritis, atopic dermatitis, and cutaneous lupus. By using systems biology approaches, we have revealed robust disease associated signals and candidates for downstream functional assays of psoriasis and facilitated the identification of genetic signature for psoriatic arthritis risk. My research also focuses on the development and implementation of computational pipeline for genomic data to identify novel disease-associated transcripts as well as context-specific inflammatory responses for inflammatory disorders.
Qualifications
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Research FellowUniversity of Michigan, Biostatistics, USA
2010 - 2015
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberMM-PKUHSC Joint Institute
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberGlobal REACH
Recent Publications
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Blauvelt A, Jiang R, Shi L, Tsoi LC, Bogle R, Fox J, Gharaee-Kermani M, Billi AC, Matheson RT, Photowala H, Gudjonsson JE, Ehst BD. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleA randomized phase 2 clinical trial to treat moderate-to-severe plaque psoriasis patients with high-induction dosing of risankizumab
DOI:10.1038/s41467-025-67475-0 PMID: 41381642 -
Jiang R, Fang Z, Wang Y, Huang B, Liu J, Tsoi LC, Bogle R, Zhang Z, Kuang Y, Li X, Dong L, Jin L, Gudjonsson JE, Yin M, Chen X. Cell Discovery, 2026 Dec 1; 12 (1):Journal ArticleAuthor Correction: LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation (Cell Discovery, (2025), 11, 1, (84), 10.1038/s41421-025-00837-6)
DOI:10.1038/s41421-026-00917-1 -
Jiang R, Kirma J, Fox J, Xing X, Wang J, Sarkar MK, Bogle R, Do T, Coon A, Cole C, Plazyo O, Rew JE, Zhang H, Kahlenberg JM, Billi AC, Bachelez H, Tsoi LC, Harms PW, Shao S, Chen X, Gudjonsson JE. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleDynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis
DOI:10.1038/s41467-025-67917-9 PMID: 41436466 -
Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J, Åsvold BO, Barton A, Baudry D, Bowes J, Brumpton B, Bruno S, Chandran V, Chatelain C, de Rinaldis E, Elder JT, Ellinghaus D, Foerster J, Franke A, Gladman DD, Gulliver W, Hüffmeier U, Huilaja L, Hveem K, Khader S, Kingo K, Klinger K, Kolbinger F, Kõks S, Liao W, Nair RP, Nititham J, Rahman P, Reis A, Sagoo MK, Stuart PE, Tasanen K, Traks T, Tsoi LC, Uebe S, Watts K, Wright A, Wilcox L, Walton S, Walsh S, Wahie S, Wade M, Wachsmuth R, Verdolini R, Topliffe J, Thomson M, Taylor M, Taghipour K, Sundararaj K, Stefanescu S, Sinha T, Sands K, Salvary I, Rotarescu R, Rose R, Reeken S, Ranasinghe A, Ramsay H, Ponnambath N, Perera G, Popli U, Owen C, Norris P, Murphy R, Mellor S, McKenna K, McCormack S, McBride S, Lyon C, Lewis H, Levell N, Lees T, Layton A, Lawson N, Labinoti L, Khorshid M, Kalavala M, Joseph T, Johnson S, Hammonds F, Godwin A, Gkini MA, Ferguson L, Fahy C, Dymond H, Duckworth M, Domanne E, Diba V, DeSilva B, Desai T, DeGiovanni C, Davies E, Darne S, Costache M, Cliff S. Genome Medicine, 2026 Dec 1; 18 (1):Journal ArticleGenetic liability to psoriasis predicts severe disease outcomes
DOI:10.1186/s13073-025-01561-2 PMID: 41408349 -
Moon JY, Wolf SJ, Joshi AD, Zhang H, Shadiow J, Bauer TM, Mangum KD, Hughes LD, Audu CO, Melvin WJ, Barrett EC, Rocco S, de Jimenez GS, Estor AL, Nelapudi M, Li Q, Bogle R, Levi B, Davis FM, Obi AT, Moore BB, Tsoi LC, Gudjonsson JE, Gallagher KA. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleIL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3
DOI:10.1038/s41467-025-67456-3 PMID: 41413388 -
Jiang R, Bogle R, Xing X, Kirma J, Fox J, Harms PW, Do T, Billi AC, Kahlenberg JM, Modlin RL, Teles R, West J, Mangold A, Zhang H, Schneider MA, Bruno S, Roediger B, Martiny-Baron G, Tsoi LC, Hacini-Rachinel F, Röhn TA, Gudjonsson JE. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleSingle-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus
DOI:10.1038/s41467-026-70506-z PMID: 41832141 -
Assan F, Tragin M, Marella S, Lipecka J, Roger K, Zarhrate M, Bondet V, Nguyen V, Akroun F, Nitschké P, Guerrera IC, Bole C, Izmiryan A, Puig-Lombardi ME, Fox J, Kirma J, Zhang H, Gu Y, Bogle R, Boniface K, Seneschal J, Seabra L, Lepelley A, Frémond ML, Bondurand N, Jouanguy E, Modlin RL, Casanova JL, Di Domizio J, Gilliet M, Sbidian E, Battistella M, Mahé E, Guégan S, Tsoi LC, Richette P, Claudepierre P, Rigolet A, Giannesini C, Costanzo A, Duffy D, Rosenberg BR, Sathishkumar D, Bourrat E, Chang CH, Hovnanian A, Gudjonsson JE, Crow YJ, Bachelez H. Journal of Experimental Medicine, 2026 Sep 7; 223 (9):Journal ArticleADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype
DOI:10.1084/jem.20260054 PMID: 42424135 -
He X, Juriga N, Callow B, Salih S, Joshi A, Bogle R, Tsoi LC, Obi A, Gudjonsson JE, Gallagher K, Davis FM. Arterioscler Thromb Vasc Biol, 2026 Aug 20;Journal ArticleMLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.
DOI:10.1161/ATVBAHA.126.324552 PMID: 42619610
Featured News & Stories
Department News
Alan Boyle, Lydia Freddolino and Lam (Alex) Tsoi receive promotions!
The Gilbert S. Omenn Department of Computational Medicine and Bioinformatics is pleased to announce the following faculty promotions
