Lam (Alex) C Tsoi, PhD
Associate Professor of Dermatology
Associate Professor of Computational Medicine and Bioinformatics
Research Associate Professor, Mary H Weiser Food Allergy
Medical School and Research Associate Professor, Biostatistics
School of Public Health
[email protected]
Available to mentor
Lam (Alex) C Tsoi, PhD
Associate Professor
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About
My research focuses on identifying the genetic and genomic components for psoriasis, and understanding their biological effect and contribution to disease heterogeneity. I currently direct the Center for Cutaneous Bioinformatics at the University of Michigan, and I am the associate director of the Functional Analytic Core of the P30-funded University of Michigan Skin Biology Disease and Resource Center.
I have been actively involved in coordinating and conducting different genetic and genomic studies to understand the pathophysiology of different immune-mediated disorders including psoriasis, psoriatic arthritis, atopic dermatitis, and cutaneous lupus. By using systems biology approaches, we have revealed robust disease associated signals and candidates for downstream functional assays of psoriasis and facilitated the identification of genetic signature for psoriatic arthritis risk. My research also focuses on the development and implementation of computational pipeline for genomic data to identify novel disease-associated transcripts as well as context-specific inflammatory responses for inflammatory disorders.
Qualifications
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Research FellowUniversity of Michigan, Biostatistics, USA
2010 - 2015
Center Memberships
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Center MemberAI and Digital Health Innovation
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Center MemberMM-PKUHSC Joint Institute
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberGlobal REACH
Recent Publications
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Blauvelt A, Jiang R, Shi L, Tsoi LC, Bogle R, Fox J, Gharaee-Kermani M, Billi AC, Matheson RT, Photowala H, Gudjonsson JE, Ehst BD. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleA randomized phase 2 clinical trial to treat moderate-to-severe plaque psoriasis patients with high-induction dosing of risankizumab
DOI:10.1038/s41467-025-67475-0 PMID: 41381642 -
Jiang R, Kirma J, Fox J, Xing X, Wang J, Sarkar MK, Bogle R, Do T, Coon A, Cole C, Plazyo O, Rew JE, Zhang H, Kahlenberg JM, Billi AC, Bachelez H, Tsoi LC, Harms PW, Shao S, Chen X, Gudjonsson JE. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleDynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis
DOI:10.1038/s41467-025-67917-9 PMID: 41436466 -
Moon JY, Wolf SJ, Joshi AD, Zhang H, Shadiow J, Bauer TM, Mangum KD, Hughes LD, Audu CO, Melvin WJ, Barrett EC, Rocco S, de Jimenez GS, Estor AL, Nelapudi M, Li Q, Bogle R, Levi B, Davis FM, Obi AT, Moore BB, Tsoi LC, Gudjonsson JE, Gallagher KA. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleIL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3
DOI:10.1038/s41467-025-67456-3 PMID: 41413388 -
Assan F, Tragin M, Marella S, Lipecka J, Roger K, Zarhrate M, Bondet V, Nguyen V, Akroun F, Nitschké P, Guerrera IC, Bole C, Izmiryan A, Puig-Lombardi ME, Fox J, Kirma J, Zhang H, Gu Y, Bogle R, Boniface K, Seneschal J, Seabra L, Lepelley A, Frémond M-L, Bondurand N, Jouanguy E, Modlin RL, Casanova J-L, Di Domizio J, Gilliet M, Sbidian E, Battistella M, Mahé E, Guégan S, Tsoi LC, Richette P, Claudepierre P, Rigolet A, Giannesini C, Costanzo A, Duffy D, Rosenberg BR, Sathishkumar D, Bourrat E, Chang CH, Hovnanian A, Gudjonsson JE, Crow YJ, Bachelez H. J Exp Med, 2026 Sep 7; 223 (9):Journal ArticleADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype.
DOI:10.1084/jem.20260054 PMID: 42424135 -
Wang C, Geng X, Abdelrahman S, Fu Y, Kady N, Rauf MA, Hristov A, Tejasvi T, Murga-Zamalloa C, Tsoi L, Welch J, Fox J, Carty SA, Gudjonsson JE, Wilcox RA. Blood, 2026 Jun 30;Journal ArticleA single-cell atlas identifies oncogenic transcriptional programs and immune escape mechanisms in CTCL.
DOI:10.1182/blood.2025032507 PMID: 42378251 -
Mangold A, Vleugels RA, Paik JJ, Shahriari N, Castillo RL, Gehlhausen J, Jiang R, Sluzevich JC, Haemel AK, Fox JC, Bogle R, Roberts BT, Penner S, Li X, Ramirez Z, Tsoi A, Shaw K, Cascino M, Johnson BM, Kahlenberg JM, Christopher-Stine L, Fernandez AP, Fiorentino DF, Werth VP, Gudjonsson JE. 2026 Jun 28; medRxiv,PreprintClinical and Molecular Effects of TYK2/JAK1 Inhibition in Dermatomyositis
DOI:10.64898/2026.06.15.26354270 -
Jiang R, Blauvelt A, Shi L, Tsoi LC, Bogle R, Fox J, Gharaee-Kermani M, Chen L, Zhang H, Xing X, Sarkar MK, Plazyo O, Kahlenberg JM, Billi AC, Matheson RT, Photowala H, Ehst BD, Gudjonsson JE. Immunity, 2026 Jun 9; 59 (6): 1758 - 1775.e6.Journal ArticleA longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit
DOI:10.1016/j.immuni.2026.05.002 PMID: 42208526 -
Ceccacci S, Minh Pham HD, Dessaignes M, Mirzayan J, Roger K, Tsoi LC, Harms PW, Gudjonsson JE, Puig Lombardi ME, Guerrera IC, Hovnanian A. 2026 Jun 4;PreprintMultiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey Disease.
DOI:10.64898/2026.06.01.729262 PMID: 42282850
Featured News & Stories
Department News
Alan Boyle, Lydia Freddolino and Lam (Alex) Tsoi receive promotions!
The Gilbert S. Omenn Department of Computational Medicine and Bioinformatics is pleased to announce the following faculty promotions
