John Varga, MD, FACP, MACR

portrait of John Varga
Frederick G L Huetwell Research Professor of Rheumatology
Professor of Internal Medicine
Professor of Dermatology and Section Head
Division of Rheumatology
Medical School
Available to mentor
John Varga, MD, FACP, MACR
portrait of John Varga
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • About

    John Varga MD attended Columbia University in New York, and obtained his medical degree from New York University. He completed Internal Medicine Residency at Rhode Island Hospital in Providence and Rheumatology Fellowship at Boston University. Following post-doctoral research at the University of Pennsylvania, he was on the faculty of the University of Illinois and Northwestern University in Chicago, and recently was recruited to Chief of Rheumatology at the University of Michigan. For the past three decades, Varga’s research has focused on fibrosis and the application of precision medicine approaches to improve patient outcomes. His lab, continuously funded by the NIH, investigates immunological and cellular mechanisms of fibrosis. He has served as a charter member of the NIH ACTS Study section and Co-Editor of Arthritis and Rheumatology, and is a member of the ACR Board of Directors. He is the author of more than 380 journal articles and book chapters and three textbooks. He has mentored over 20 post-doctoral MD and PhD trainees, many of whom have gone on to develop successful academic or industry careers.

    Links

    • John Varga Sclerolab

    Qualifications

    • Post-doctoral Research Fellow, T32
      University of Pennsylvania, Philadelphia, United States
      1985 - 1987
    • Rheumatology Fellow
      Boston University School of Medicine, Boston, United States
      1983 - 1985
    • Intern and Resident in Medicine
      Rhode Island Hospital/Brown, United States
      1980 - 1983
    • MD
      New York University School of Medicine, New York, NY, United States
      1978 - 1980
    • BA
      Columbia University, New York, United States
      1971 - 1975

    Center Memberships

    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Global REACH
    • Center Member
      Center for Computational Medicine and Bioinformatics

    Research Overview

    My lab studies inflammation and metabolism in the context of chronic autoimmune and fibrotic diseases. We use mouse models, patient samples, genetics and genomics to identify mechanisms of disease and novel targets for therapy. Our research is patient-oriented and we embrace of a tight "bench-to-bedside-to bench" approach. Our Michigan Scleroderma Program afford unique access to patients including genetics and biological specimen, for our research, including early-stage clinical trials.

    Visit the John Varga Sclerolab website: https://medresearch.umich.edu/labs-departments/labs/sclerolab

    Recent Publications

    See All Publications
    • Journal Article
      Multi-cytokine based TWAS for seven inflammatory skin disorders identify candidate causal genes in keratinocytes.
      Zhang H, Patrick MT, Sarkar MK, Bogle R, Li Q, Uppala R, Perez White BE, Petukhova L, Dand N, Stuart PE, Christiano AM, Simpson MA, Barker JN, Weidinger S, Modlin RL, Betz RC, Khanna D, Varga J, Kahlenberg JM, He K, Elder JT, Zhou X, Gudjonsson JE, Tsoi LC. J Allergy Clin Immunol, 2026 May 26; DOI:10.1016/j.jaci.2026.05.013
      PMID: 42203178
    • Journal Article
      Aurora A kinase activation contributes to the fibrotic phenotype in systemic sclerosis through primary cilia shortening.
      Wells R, Caballero-Ruiz B, Mulipa P, Timmis AJ, Teves ME, Varga J, Del Galdo F, Ross RL, Riobo-Del Galdo NA. Arthritis Res Ther, 2026 May 7; DOI:10.1186/s13075-026-03826-6
      PMID: 42098768
    • Preprint
      Aurora A kinase activation contributes to the fibrotic phenotype in Systemic Sclerosis through primary cilia shortening
      Wells R, Ruiz BC, Mulipa P, Timmis AJ, Teves ME, Varga J, Del Galdo F, Ross RL, Galdo NAR-D. 2026 Mar 18; bioRxiv, DOI:10.64898/2026.03.13.711548
    • Journal Article
      Nintedanib Attenuates Profibrotic Gene Expression in a 3D Organotypic Culture Model of Systemic Sclerosis Skin Fibrosis.
      Shah K, Verma P, Hamil T, Dey P, Bale S, Yalavarthi B, Tsou P-S, Gudjonsson JE, Khanna D, Varga J, Bhattacharyya S. J Invest Dermatol, 2026 Mar 6; DOI:10.1016/j.jid.2026.01.046
      PMID: 41796853
    • Journal Article
      A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
      Su EJ, Tsou P-S, Warnock M, Subbotina N, Mann K, Vichaikul S, Rosek A, Leung L, Xing X, Xing E, Plazyo O, Bogle R, Tsoi LC, Emal CD, Khanna D, Varga J, Sisson TH, Gudjonsson JE, Lawrence DA. JCI Insight, 2026 Feb 17; DOI:10.1172/jci.insight.195005
      PMID: 41701900
    • Preprint
      Targeting activated IL-23 signaling in Scleroderma by tildrakizumab
      Verma P, Goncalves RM, Bale S, Silverman J, Hamill T, Shah K, Yalavarthi B, Bhattacharyya D, Bhattacharyya S, Varga J. 2026 Feb 5; bioRxiv, DOI:10.64898/2026.01.30.701821
    • Journal Article
      CCL19+fibroblast-CCR7+T-cell crosstalk coordinates immunofibrotic signalling networks in systemic sclerosis
      Guo W, Li Z, Xu D, Li T, Li X, Fang D, Zhang X, Jin Y, Xing D, Chen Z, Yuan X, Wang Z, Dong C, Xu H, Varga J, Wang J, Ge J, Mu R. British Journal of Dermatology, 2026 Feb 1; 194 (2): 326 - 339. DOI:10.1093/bjd/ljaf444
      PMID: 41321019
    • Journal Article
      Development of a tool to map SSc pain sources, characteristics and management experiences: The SPIN Pain Assessment Tool
      Dal Santo T, Carrier ME, Nassar EL, Dal Santo C, Hu S, Kwakkenbos L, Bartlett SJ, Fox RS, Lee YC, Varga J, Thombs BD, McKenzie JAL, Lawrie-Jones A, Mieszczak T, Sauve M. Rheumatology, 2026 Feb 1; 65 (2): DOI:10.1093/rheumatology/keag039
      PMID: 41578942

    Featured News & Stories

    The Doziers stand next to each other smiling with 15 members of the Critical Care Unit nursing team standing in a group behind them.
    Philanthropy News

    Compassionate gifts turn heartbreak into hope

    Margie and Tillman Dozier are honoring their daughter, Daria, through their generous support of critical care nursing and the Department of Rheumatology at Michigan Medicine.
    John Varga, MD
    Department News

    Dr. John Varga Honored with Prestigious Lifetime Achievement Award

    At the opening ceremony of the 19th International Workshop on Scleroderma Research, held from July 26–30, 2025 at St. John’s College in Cambridge, UK, Dr. John Varga was awarded the Edith Busch Foundation Lifetime Achievement Award.
    microscope
    Health Lab

    Antibody targeting CD38 enzyme shows positive impact in treating systemic sclerosis

    Using the Ab38 antibody to target the CD38 enzyme could be a new gateway to treat and prevent fibrosis for patients with systemic sclerosis.