Todd C Hollon, MD

 Todd C. Hollon
Joseph R Novello M.D.
Alfredo Quinones-Hinojosa M.D.
Research Professor of Neurosurgery
Associate Professor of Neurosurgery
Program Director
Artificial Intelligence in Neurosurgery
Medical School
Office:
University of Michigan–Ann Arbor
Department of Neurosurgery
1500 East Medical Center Drive
Ann Arbor, MI 48109-5338
Available to mentor
Todd C Hollon, MD
Todd C. Hollon
Associate Professor
  • Qualifications
  • Center Memberships
  • Recent Publications

  • Manage Your Profile

    • Qualifications
    • Residency
      University of Michigan–Ann Arbor, Department of Neurosurgery, Ann Arbor, United States
      2013 - 2020
      Residency
    • Residency
      University of Michigan–Ann Arbor, Ann Arbor, United States
      2019 - 2020
      Chief Resident
    • Clinical Fellowship
      University of Utah, Salt Lake City, United States
      2020 - 2020
      Clinical Fellowship
    • Postdoctoral Fellow
      University of Michigan–Ann Arbor, Ann Arbor, United States
      2016 - 2018
      Postdoctoral Fellowship
    • MD
      Ohio State University, Columbus, Ohio, United States
      2009 - 2013
    • BA
      University of Michigan, Ann Arbor, MI, United States
      2004 - 2008

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      AI and Digital Health Innovation
    • Center Member
      Frankel Institute for Heart and Brain Health

    Recent Publications

     See All Publications
    • Journal Article
      Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging
      Hollon T, Jiang C, Chowdury A, Nasir-Moin M, Kondepudi A, Aabedi A, Adapa A, Al-Holou W, Heth J, Sagher O, Lowenstein P, Castro M, Wadiura LI, Widhalm G, Neuschmelting V, Reinecke D, von Spreckelsen N, Berger MS, Hervey-Jumper SL, Golfinos JG, Snuderl M, Camelo-Piragua S, Freudiger C, Lee H, Orringer DA. Nature Medicine, 2023 Apr 1; 29 (4): 828 - 832. DOI:10.1038/s41591-023-02252-4
      PMID: 36959422
    • Journal Article
      AI-driven label-free Raman spectromics for intraoperative spinal tumor assessment
      Reinecke D, Müller N, Meissner AK, Fürtjes G, Leyer L, Wang C, Ion-Margineanu A, Maarouf N, Smith A, Hollon TC, Jiang C, Hou X, Al-Shughri A, Körner LI, Widhalm G, Roetzer-Pejrimovsky T, Snuderl M, Camelo-Piragua S, Golfinos JG, Goldbrunner R, Orringer DA, von Spreckelsen N, Neuschmelting V. Npj Digital Medicine, 2026 Dec 1; 9 (1): DOI:10.1038/s41746-025-02279-6
    • Journal Article
      Health system learning enables generalist neuroimaging models
      Kondepudi A, Rao A, Zhao C, Lyu Y, Harake S, Banerjee S, Ogle J, Joshi R, Meissner AK, Hou X, Jiang C, Chowdury A, Srinivasan A, Athey B, Gulani V, Pandey A, Lee H, Hollon T. Nature Medicine, 2026 Aug 1; 32 (8): 2831 - 2837. DOI:10.1038/s41591-026-04497-1
      PMID: 42432292
    • Journal Article
      Learning neuroimaging models from health system-scale data
      Lyu Y, Harake S, Chowdury A, Banerjee S, Gologorsky R, Liu S, Meissner AK, Rao A, Zhao C, Kondepudi A, Jiang C, Hou X, Joshi RS, Neuschmelting V, Srinivasan A, Kleindorfer D, Athey B, Gulani V, Pandey A, Lee H, Hollon T. Nature Biomedical Engineering, 2026 Aug 1; 10 (8): 1646 - 1658. DOI:10.1038/s41551-025-01608-0
      PMID: 41652068
    • Journal Article
      Predicting postoperative hospice enrollment following stereotactic brain biopsy: a retrospective study and risk score development.
      Tripathy A, Harake ES, Ahmad A, Sharba N, Li A, Saleh S, Sagher O, Heth JA, Altshuler D, Hollon TC, Thompson BG, Pandey AS, Umemura Y, Al-Holou WN. J Neurosurg, 2026 Jul 31; 1 - 13. DOI:10.3171/2026.2.JNS251994
      PMID: 42537242
    • Journal Article
      Benchmarking the Brain’s Blood Vessels — Why We Need Specialized Models in Medical AI
      Hollon T. NEJM AI, 2026 Jul 25; 3 (8): DOI:10.1056/aie2600897
    • Journal Article
      AI-Powered Pipeline Transforms Neurosurgical Articles Into High-Quality Graphical Abstracts
      Alyakin A, Stryker J, Lee JV, Feng R, Hollon T, Kondziolka D, Oermann EK. Neurosurgery Practice, 2026 Jun 1; 7 (2): 1 - 7. DOI:10.1227/neuprac.0000000000000230
    • Preprint
      SIGNAL: A Scalable, Real-World Model for Rapid Intraoperative Molecular Classification of Gliomas Using Stimulated Raman Histology.
      Goff NK, Markert JE, Reinecke D, Springer A, Chen AM, Park M, Malte G, Scotford-Broemmer K, Hoonsbeen S, Eddy K, Chowdury A, Jiang C, Kondepudi A, Meissner A-K, Fürtjes G, Müller N, Neuschmelting V, Pekmezci M, Young J, Freudinger C, Snuderl M, Berger M, Hervey-Jumper S, Golfinos JG, Hollon T, Orringer DA. 2026 May 13; DOI:10.64898/2026.05.11.26350247
      PMID: 42180331

    Featured News & Stories

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    Dose of Reality

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    Health Lab

    An AI model that can read and diagnose a brain MRI in seconds

    An AI-powered model developed at University of Michigan can read a brain MRI and diagnose a person in seconds, new research finds.
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    Health Lab

    In 10 seconds, AI model detects cancerous brain tumor often missed during surgery

    Researchers have developed an AI powered model that — in 10 seconds — can determine during surgery if any part of a cancerous brain tumor that could be removed remains, a study published in Nature suggests.