Longhua Guo, PhD

 portrait of Longhua Guo
Assistant Professor of Molecular and Integrative Physiology
Assistant Professor of Cell and Developmental Biology
Research Assistant Professor
Institute of Gerontology
Medical School
[email protected]
Available to mentor
Longhua Guo, PhD
portrait of Longhua Guo
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • Qualifications
    • Postdoc
      University of California, Los Angeles, Human Genetics, Los Angeles, United States
      2017 - 2022
    • Postdoc
      Stowers Institute for Medical Research, Kansas City, United States
      2016 - 2017
    • PhD
      University of Utah, Salt Lake City, United States
      2009 - 2016

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Frankel Institute for Heart and Brain Health

    Research Overview

    Genetics, Aging, Regeneration, Age reversal, Rejuvenation

    Recent Publications

     See All Publications
    • Journal Article
      Molecular evolution of animal aging.
      Nussey DH, d'Adda di Fagagna F, Bardin AJ, Blau H, Brunet A, Bulavin DV, Guo L, Hara E, Junker JP, Gorbunova V, Mittelbrunn M, Rera M, Reznick J, Seluanov A, Schumacher B, Teeling EC, Valenzano DR, Ye J, Yun MH, Garinis GA, Gilson E. EMBO J, 2026 Feb 27; DOI:10.1038/s44318-026-00725-z
      PMID: 41760805
    • Journal Article
      Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice
      Murach KA, Dungan CM, Chambers TL, Horvath S, Nandakumar J, Gladyshev VN, Pletcher SD, Dai X, Guo L. Aging Cell, 2025 Nov 1; 24 (11): DOI:10.1111/acel.70236
      PMID: 40947308
    • Journal Article
      Genetic and Genomic Insights into Planarian Biology
      Guo L. Annual Review of Genetics, 2025 Aug 19; 59 (1): 315 - 340. DOI:10.1146/annurev-genet-011725-091634
      PMID: 40829791
    • Journal Article
      Mixed, not stirred: Genomic data confirm the first case of interspecific hybridization in planarian triclads (Platyhelminthes: Tricladida) and raise questions about a possibly novel form of hybrid speciation
      Dols-Serrate D, Guo L, Kruglyak L, Riutort M. Molecular Phylogenetics and Evolution, 2025 Jun 1; 207: DOI:10.1016/j.ympev.2025.108339
      PMID: 40132772
    • Journal Article
      Aging, regeneration and whole-body rejuvenation in long-lived planarians
      Dai X, Guo L. Nature Aging, 2025 May 1; 5 (5): 736 - 737. DOI:10.1038/s43587-025-00863-9
    • Journal Article
      Regeneration leads to global tissue rejuvenation in aging sexual planarians
      Dai X, Li X, Tyshkovskiy A, Zuckerman C, Cheng N, Lin P, Paris D, Qureshi S, Kruglyak L, Mao X, Nandakumar J, Gladyshev VN, Pletcher S, Sobota J, Guo L. Nature Aging, 2025 May 1; 5 (5): 780 - 798. DOI:10.1038/s43587-025-00847-9
    • Journal Article
      Oogenesis involves a novel nuclear envelop remodeling mechanism in Schmidtea mediterranea
      Guo L, Guo F, Zhang S, Zeng A, Yi K, McClain M, Kuhn CD, Parmely T, Alvarado AS. Developmental Biology, 2025 Apr 1; 520: 13 - 20. DOI:10.1016/j.ydbio.2024.12.018
      PMID: 39732384
    • Journal Article
      Extraordinary model systems for regeneration
      Accorsi A, Guo L, Marshall WF, Mommersteeg MTM, Nakajima YI. Development Cambridge, 2024 Oct 1; 151 (20): DOI:10.1242/dev.203083
      PMID: 39012059

    Featured News & Stories
    Great Minds, Greater Discoveries Stories

    Research Scout Scholar: Longhua Guo, PhD

    Meet Dr. Longhua Guo, a Great Minds Research Scouts scholar at the University of Michigan Medical School.
         pointing to worm on screen
    Health Lab

    Planarian worms can regenerate into a more youthful version of themselves

    Study finds planarian worms can regenerate into a more youthful version of themselves.
    Department News

    CDB is excited to welcome Longhua Guo, PhD!

    Longhua's research focuses on aging, regeneration, and global rejuvenation, using planarians (Schmidtea mediterranea) and leopard geckos (Eublepharis macularius). The Guo lab applies a variety of techniques in genetics, genomics, molecular, cellular, and developmental biology.
    News Release

    NIH High-Risk, High-Reward program awards three U-M Medical School investigators

    Three U-M investigators—Changyang Linghu, Longhua Guo and Sundeep Kalantry—have been acknowledged by the National Institutes of Health’s (NIH) prestigious High-Risk, High-Reward Research program.
    Department News

    Dr. Longhua Guo named a 2024 Pew Scholar

    Congrats to Dr. Longhua Guo for being named a 2024 Pew Scholar to support his research on the molecular and cellular processes that reverse tissue aging.