Jiandie Lin, PhD
Bradley M Patten Collegiate Professor in the Life Sciences
Professor of Cell and Developmental Biology
Medical School and Research Professor
Life Sciences Institute
[email protected]
Available to mentor
Jiandie Lin, PhD
Research Professor
Manage Your Profile
About
Metabolic disease, genomics, hormonal signaling, fatty liver disease
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
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Center MemberCaswell Diabetes Institute
Research Overview
Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.
We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.
Recent Publications
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Qiu X, Lu Y, Tang Y, Zhou L, Lee YT, Meng Z, Chen Z, Pradeepa F, Faccioli LA, Hu Z, Soto-Gutierrez A, Li S, Lin JD. Journal of Clinical Investigation, 2026 May 1; 136 (9):Journal ArticleTHEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice
DOI:10.1172/JCI199303 PMID: 42065240 -
Lin J. 2026 Mar 25;PresentationInterorgan crosstalk and reprogramming of the liver microenvironment in metabolic liver disease
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Lu H, Xue C, Zhao Y, Sun J, Zhao C, Zhang X, Zhao G, Liu Y, Liu H, Deng Y, Wang Y, Zhang C, Liu Y, Zeng L, Yang Y, Li B, Ding S, Zhou L, Kuang H, Wang Z, Ju W, Lin H, Lin J, Guo Y, Chang L, Zhao H, Wang J, Lin J, Zheng L, Chen YE, Zhang J. Advanced Science, 2025 Dec 29; 12 (48):Journal ArticleCRISPR-MI and scRNA-Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development
DOI:10.1002/advs.202412227 PMID: 41058009 -
Ikeda T, Hong S, Yoshida S, Srivastava SP, Kunamneni A, Yao Y, Khuperkar O, Basrur V, Kuang H, Kachman M, Raskind A, Baum H, Joshi A, Swaroop V, Thurman A, Kopasz-Gemmen O, Kandukuri S, Pradeepa FNU, Yonekura H, Lin JD, Inoki K. Cell Reports, 2025 Oct 28; 44 (10):Journal ArticleHUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
DOI:10.1016/j.celrep.2025.116382 PMID: 41075246 -
Meng Z, Qiu X, Chen Z, Lee YT, Zhou L, Lu Y, Liu T, Li S, Levi B, Gallagher KA, Lin JD. Jhep Reports, 2025 Aug 1; 7 (8):Journal ArticleMyeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis
DOI:10.1016/j.jhepr.2025.101488 -
Meng Z, Lin JD. Hepatology, 2025 Jun 1; 81 (6): 1638 - 1640.Journal ArticleBariatric surgery meets TREM2+ macrophages to alleviate MASH independent of weight loss
DOI:10.1097/HEP.0000000000001125 PMID: 39417882 -
Ikeda T, Hong S, Yoshida S, Kunamneni A, Srivastava SP, Yao Y, Basrur V, Kuang H, Kachman M, Baum H, Joshi A, Swaroop V, Thurman A, Kopasz-Gemmen O, Kandukuri S, Khuperkar O, Pradeepa F, Yonekura H, Lin JD, Inoki K. 2025 Apr 26; bioRxiv,PreprintHUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
DOI:10.1101/2025.04.22.650033 -
Arany Z, Song B-L, Coppari R, Lin J, Kalaany N, Steinberg G. Cell Metab, 2025 Apr 1; 37 (4): 791 - 793.Journal ArticleCell Metabolism 20th anniversary Voices: Part 1 of 3.
DOI:10.1016/j.cmet.2025.03.005 PMID: 40174571
Featured News & Stories
Department News
New Publication by the Jiandie Lin Lab!
Cell Reports published "Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms."
Department News
New Publication from the Lin Lab
A new publication from the Lin Lab has been published in Science Translational Medicine.
Department News
New Publication from the Lin Lab
"Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis," has been published in JCI Insight.
Department News
New Publication by the Lin Lab
"Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice," has been published in Hepatology.
