Ajay Tambralli, MD
Clinical Assistant Professor
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[email protected]
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Ajay Tambralli, MD
Clinical Assistant Professor
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About
Dr. Tambralli is Clinical Assistant Professor in both adult and pediatric rheumatology and sees patients across the age spectrum. He received his bachelor’s and M.D. degrees at the University of Alabama at Birmingham, and then completed a residency program in Internal Medicine and Pediatrics at the University of Rochester. He then moved to Michigan to pursue dual fellowships in adult and pediatric rheumatology at the University of Michigan. During fellowship, he was awarded the prestigious American College of Rheumatology Distinguished Fellow Award, as well as a Rheumatology Research Foundation Scientist Development Award.
Dr. Tambralli cares for children, adolescents, and adults with rheumatic diseases. He looks after all rheumatic diseases and sees patients with inflammatory arthritis, lupus, antiphospholipid syndrome, myositis, vasculitis, and autoinflammatory diseases.
Dr. Tambralli is also a part of the Jason Knight lab and participates in research on lupus and the antiphospholipid syndrome. He is working towards understanding the metabolic triggers of autoimmunity in these diseases and how to effectively harness them to develop better treatments.
Qualifications
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ResidencyUniversity of Rochester Medical Center, Internal Medicine - Pediatrics, Rochester, United States
Residency
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Fellowship in Adult and Pediatric RhematologyUniversity of Michigan–Ann Arbor, Ann Arbor, United States
Postdoctoral Fellowship
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MDUniversity of Alabama School of Medicine, Birmingham, AL, United States
2010 - 2014
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BSUniversity of Alabama at Birmingham, Birmingham, AL, United States
2004 - 2008
Center Memberships
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Center MemberSamuel and Jean Frankel Cardiovascular Center
Research Overview
My research interests are to understand the role of neutrophil metabolism in the pathogenesis of the antiphospholipid syndrome and systemic lupus erythematosus to develop more targeted and less toxic therapies for our patients.
Recent Publications
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Soulsby WD, Boscardin J, Knight A, Horton DB, Toupin-April K, von Scheven E, Aamir R, Abulaban K, Adams A, Lapsia CA, Ahmed H, Akoghlanian S, AlBijadi A, Allenspach E, Alpizar M, Amarilyo G, Amoruso M, Angeles-Han S, Ardoin S, Armendariz S, Dagan NA, Balboni I, Balevic S, Ballinger S, Baluta S, Barillas-Arias L, Basiaga M, Baszis K, Becker M, Begezda A, Beil E, Bell-Brunson H, Benham H, Benseler S, Bermudez-Santiago L, Bernal W, Bigley T, Bingham C, Binstadt B, Black C, Blackmon B, Blakley M, Bohnsack J, Boneparth A, Bradfield H, Bridges J, Brooks E, Brothers M, Brown D, Brunner H, Buckley L, Buckley M, Buckley M, Bukulmez H, Bullock D, Cancino A, Canna S, Cannon L, Canny S, Cartwright V, Chalom E, Chang J, Chang J, Chang M, Chang-Hoftman A, Chen A, Chiraseveenuprapund P, Ciaglia K, Cidon M, Co D, Cohen E, Connor R, Cook K, Cooper A, Cooper J, Corbin K, Correll C, Cron R, Curry M, Dagci A, Dalrymple A, Datyner E, Davis T, De Ranieri D, Dean J, DeCoste C, Dedeoglu F, DeGuzman M, Delnay N, DeSantis EL, Devine R, Dhalla M, Dhanrajani A, Dissanayake D, Dizon B, Drew J, Driest K, Du Q, Duncan E. Arthritis Care and Research, 2026 Oct 1; 78 (10): 1552 - 1563.Journal ArticleCumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study
DOI:10.1002/acr.80051 PMID: 41931026 -
Gan Y, Liang W, Liu C, Yalavarthi S, Warnock M, Sabb K, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Emal CD, Tsou PS, Shi H, Zuo Y, Lawrence DA, Knight JS. Journal of Autoimmunity, 2026 Jun 1; 161:Journal ArticleEndothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome
DOI:10.1016/j.jaut.2026.103563 PMID: 42048835 -
de Moraes Mazetto Fonseca B, NaveenKumar SK, Yalavarthi S, Sugur K, Newman TG, Hoy CK, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Zuo Y, Orsi FA, Holinstat M, Knight JS. Arthritis and Rheumatology, 2026 Apr 1; 78 (4): 896 - 903.Journal ArticleProthrombotic Activation of Platelet Pannexin-1 Channels in Antiphospholipid Syndrome
DOI:10.1002/art.70001 PMID: 41327823 -
NaveenKumar SK, Newman TG, Mazetto Fonseca B, Yalavarthi S, Flores Nascimento MC, Sabb K, Kmetova K, Chong E, Sugur K, Ranger CH, Tompkins MP, Sarosh C, Madison JA, Tambralli A, Schaefer JK, Holinstat M, Zuo Y, Knight JS. Blood Advances, 2025 Nov 11; 9 (21): 5423 - 5435.Journal ArticleA disrupted adenosinergic axis facilitates platelet activation in APS: exploring a novel therapeutic target
DOI:10.1182/bloodadvances.2025016162 PMID: 40705954 -
Shi H, Liang W, Yang Z, Hoy CK, Wang Q, Ding Z, Pan H, Shi Y, Shen Y, Sarosh C, Yalavarthi S, Kapoor P, Hudgins L, Vance CE, Wasikowski R, Figueroa-Parra G, Tambralli A, Madison JA, Tsoi LC, Gudjonsson JE, Yang C, Duarte-García A, Zuo Y, Billi AC, Tsou PS, Knight JS. Circulation, 2025 Nov 4; 152 (18): 1295 - 1310.Journal ArticleMicrovascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling
DOI:10.1161/CIRCULATIONAHA.125.073552 PMID: 40878676 -
King S, Sarosh C, Tambralli A, Madison J, Zuo Y, Sood S, Girard J, Shevell L, Knight J, Schaefer J. Blood, 2025 Dec 8; 146 (Supplement 1): 3109Proceeding / Abstract / PosterAspirin use among patients with thrombotic antiphospholipid antibody syndrome
DOI:10.1182/blood-2025-3109 -
Tambralli A, Knight JS. Journal of Clinical Investigation, 2025 Nov 3; 135 (21):Journal ArticleNeutrophils take center stage in VEXAS syndrome pathogenesis
DOI:10.1172/JCI199299 PMID: 41178709 -
Blair KM, Bohinc DJ, Bane KL, Warnock M, Abuaita B, Gura C, Grinsztejn E, Marshall SH, Wilson BM, Bonomo RA, Tambralli A, Knight JS, O’Riordan MX, Lawrence DA, Stavrou EX, Sandkvist M. Circulation Research, 2025 Jun 20; 137 (1): e1 - e15.Journal ArticleAcinetobacter Baumannii Secreted Protease CpaA Inhibits Factor XII-Mediated Bradykinin Generation and Neutrophil Activation
DOI:10.1161/CIRCRESAHA.124.324764 PMID: 40357548
Featured News & Stories
Department News
What I'm Reading in APS Research: June 2026
What I’m Reading, written by Dr. Ajay Tambralli, was created to provide information on the latest APS-relevant research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Tambralli discusses molecular mimicry and APS.
Department News
What I'm Reading in APS Research: December 2025
What I’m Reading in APS Research, written by Dr. Ajay Tambralli, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Tambralli discusses somatic mutations.
Department News
What I'm Reading in APS Research: June 2025
What I’m Reading in APS Research, written by Dr. Ajay Tambralli, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of new discoveries. In this month’s edition, Dr. Tambralli explores the amazing properties of camelid antibodies and their potential applications in future therapies.
Research News
What I'm Reading in APS Research: December 2024
What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications.
Health Lab
Could targeting metabolism treat blood clots in antiphospholipid syndrome?
A research team is investigating how metabolism – the process by which cells turn sugars, fats and proteins into energy – is used to make NETs in regards to antiphospholipid syndrome.
Research News
What I'm reading in APS research | June 2024
What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Knight highlights several abstracts presented at the annual EULAR Congress.
