Ajay Tambralli, MD
Clinical Assistant Professor of Internal Medicine
Clinical Assistant Professor of Pediatrics
Medical School
[email protected]
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Ajay Tambralli, MD
Clinical Assistant Professor
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About
Dr. Tambralli is Clinical Assistant Professor in both adult and pediatric rheumatology and sees patients across the age spectrum. He received his bachelor’s and M.D. degrees at the University of Alabama at Birmingham, and then completed a residency program in Internal Medicine and Pediatrics at the University of Rochester. He then moved to Michigan to pursue dual fellowships in adult and pediatric rheumatology at the University of Michigan. During fellowship, he was awarded the prestigious American College of Rheumatology Distinguished Fellow Award, as well as a Rheumatology Research Foundation Scientist Development Award.
Dr. Tambralli cares for children, adolescents, and adults with rheumatic diseases. He looks after all rheumatic diseases and sees patients with inflammatory arthritis, lupus, antiphospholipid syndrome, myositis, vasculitis, and autoinflammatory diseases.
Dr. Tambralli is also a part of the Jason Knight lab and participates in research on lupus and the antiphospholipid syndrome. He is working towards understanding the metabolic triggers of autoimmunity in these diseases and how to effectively harness them to develop better treatments.
Qualifications
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ResidencyUniversity of Rochester Medical Center, Internal Medicine - Pediatrics, Rochester, United States
Residency
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Fellowship in Adult and Pediatric RhematologyUniversity of Michigan–Ann Arbor, Ann Arbor, United States
Postdoctoral Fellowship
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MDUniversity of Alabama School of Medicine, Birmingham, AL, United States
2010 - 2014
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BSUniversity of Alabama at Birmingham, Birmingham, AL, United States
2004 - 2008
Center Memberships
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Center MemberSamuel and Jean Frankel Cardiovascular Center
Research Overview
My research interests are to understand the role of neutrophil metabolism in the pathogenesis of the antiphospholipid syndrome and systemic lupus erythematosus to develop more targeted and less toxic therapies for our patients.
Recent Publications
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Gan Y, Liang W, Liu C, Yalavarthi S, Warnock M, Sabb K, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Emal CD, Tsou PS, Shi H, Zuo Y, Lawrence DA, Knight JS. Journal of Autoimmunity, 2026 Jun 1; 161:Journal ArticleEndothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome
DOI:10.1016/j.jaut.2026.103563 -
Mannion ML, Aswani MS, Hearld KR, Smitherman EA, Timmerman L, Curtis JR, Zic C, Zhu A, Zheng Z, Zhao YD, Zhang YJ, Zeft A, Yomogida K, Yeung R, Yalcindag A, Wu E, Wright T, Woolnough L, Wooldridge S, Wong S, Williams C, Widrick K, Westheuser V, Wershba E, Weiss P, Weiss J, Waterfield M, Walters H, Wallgren S, Walker B, Wakefield S, Wahezi D, Wagner-Weiner L, Vora S, von Scheven E, Verstegen R, Verbsky J, Vega-Fernandez P, Vasquez N, Varghese C, Vandenbergen S, Van Mater H, Vallee A, Valdovinos R, Valcarcel T, Twilt M, Twachtman-Bassett J, Tsin C, Tse T, Tse S, Treemarcki E, Toth M, Tory H, Torok K, Toib D, Todd C, Ting T, Timmerman L, Thomas N, Thomas L, Thomas B, Thieroff G, Theisen A, Thakurdeen T, Tesher M, Taxter A, Tarvin S, Tanner T, Taneja A, Tambralli A, Tal R, Taber S, Szymanski AM, Syverson G, Symington T, Swayne N, Swaffar C, Sutter M, Sundel R, Sullivan J, Sule S, Stringer E, Stoll M, Stingl C, Stevenson R, Stevens B, Stern S, Rakovchik YS, Stephens A, Stapp H, Srinivasalu H, Spitznagle J, Spiegel L, Spencer C, Son MB, Soep J, Smith J, Smith C, Sloan E. Pediatric Rheumatology, 2025 Dec 1; 23 (1):Journal ArticleDisease activity at two consecutive registry visits and subsequent medication escalation for patients with juvenile idiopathic arthritis in the CARRA registry
DOI:10.1186/s12969-025-01130-2 PMID: 40696394 -
Correll C, Burciu A, Bansal A, Dennos A, Narayanswamy D, Aubrun E, Schanberg LE, Yuhan L, Schneider R, Balevic S, Kimura Y, Beukelman T, Zic C, Zhu A, Zheng Z, Zhao YD, Zhang YJ, Zeft A, Yeung R, Yalcindag A, Wu E, Wright T, Woolnough L, Wooldridge S, Wong S, Williams C, Widrick K, Wershba E, Weiss J, Weiss P, Weiser P, Waterfield M, Walters H, Wallgren S, Walker B, Wakefield S, Wahezi D, Wagner-Weiner L, Vora S, von Scheven E, Verstegen R, Verbsky J, Vega-Fernandez P, Vasquez N, Varghese C, Van Mater H, Vallee A, Valdovinos R, Valcarcel T, Twilt M, Twachtman-Bassett J, Tsin C, Tse S, Tse T, Treemarcki E, Toth M, Tory H, Torok K, Toib D, Todd C, Ting T, Timmerman L, Thomas N, Thomas L, Thomas B, Thieroff G, Theisen A, Tesher M, Taxter A, Tarvin S, Tanner T, Taneja A, Tambralli A, Tal R, Taber S, Szymanski AM, Syverson G, Swaffar C, Sutter M, Sullivan J, Sule S, Stringer E, Stoll M, Stevenson R, Stevens B, Stern S, Sterba Rakovchik Y, Stephens A, Stapp H, Srinivasalu H, Spiegel L, Spencer C, Son MB, Soep J, Smitherman E, Smith J, Sloan E, Sivaraman V, Singer N, Shishov M. Pediatric Rheumatology, 2025 Dec 1; 23 (1):Journal ArticleLong-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry
DOI:10.1186/s12969-025-01144-w PMID: 41121260 -
Mazetto Fonseca BDM, NaveenKumar SK, Yalavarthi S, Sugur K, Newman TG, Hoy CK, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Zuo Y, Orsi F, Holinstat M, Knight JS. Arthritis Rheumatol, 2025 Dec 1;Journal ArticleProthrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome.
DOI:10.1002/art.70001 PMID: 41327823 -
King S, Sarosh C, Tambralli A, Madison J, Zuo Y, Sood S, Girard J, Shevell L, Knight J, Schaefer J. Blood, 2025 Dec 8; 146 (Supplement 1): 3109Proceeding / Abstract / PosterAspirin use among patients with thrombotic antiphospholipid antibody syndrome
DOI:10.1182/blood-2025-3109 -
Tambralli A, Knight JS. Journal of Clinical Investigation, 2025 Nov 3; 135 (21):Journal ArticleNeutrophils take center stage in VEXAS syndrome pathogenesis
DOI:10.1172/JCI199299 PMID: 41178709 -
Case S, Hill CL, Shrader P, Dennos A, Phillips T, Schanberg LE, von Scheven E, Barbour K, Knight AM, Hersh A, Son M, CARRA Registry Investigators . Lupus Sci Med, 2025 Aug 14; 12 (2):Journal ArticleDisease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.
DOI:10.1136/lupus-2025-001521 PMID: PMC12352166 -
NaveenKumar SK, Newman TG, Fonseca BM, Yalavarthi S, Flores Nascimento MC, Sabb K, Kmetova K, Chong E, Sugur K, Ranger CH, Tompkins MP, Sarosh C, Madison JA, Tambralli A, Schaefer JK, Holinstat M, Zuo Y, Knight JS. Blood Adv, 2025 Jul 24;Journal ArticleA Disrupted Adenosinergic Axis Facilitates Platelet Activation in APS: Exploring a Novel Therapeutic Target.
DOI:10.1182/bloodadvances.2025016162 PMID: 40705954
Featured News & Stories
Department News
What I'm Reading in APS Research: June 2026
What I’m Reading, written by Dr. Ajay Tambralli, was created to provide information on the latest APS-relevant research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Tambralli discusses molecular mimicry and APS.
Department News
What I'm Reading in APS Research: December 2025
What I’m Reading in APS Research, written by Dr. Ajay Tambralli, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Tambralli discusses somatic mutations.
Department News
What I'm Reading in APS Research: June 2025
What I’m Reading in APS Research, written by Dr. Ajay Tambralli, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of new discoveries. In this month’s edition, Dr. Tambralli explores the amazing properties of camelid antibodies and their potential applications in future therapies.
Research News
What I'm Reading in APS Research: December 2024
What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications.
Health Lab
Could targeting metabolism treat blood clots in antiphospholipid syndrome?
A research team is investigating how metabolism – the process by which cells turn sugars, fats and proteins into energy – is used to make NETs in regards to antiphospholipid syndrome.
Research News
What I'm reading in APS research | June 2024
What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Knight highlights several abstracts presented at the annual EULAR Congress.
