Ajay Tambralli, MD
Clinical Assistant Professor of Internal Medicine
Clinical Assistant Professor of Pediatrics
atambral@umich.edu

Available to mentor

Ajay Tambralli, MD
Clinical Assistant Professor
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Dr. Tambralli is Clinical Assistant Professor in both adult and pediatric rheumatology and sees patients across the age spectrum. He received his bachelor’s and M.D. degrees at the University of Alabama at Birmingham, and then completed a residency program in Internal Medicine and Pediatrics at the University of Rochester. He then moved to Michigan to pursue dual fellowships in adult and pediatric rheumatology at the University of Michigan. During fellowship, he was awarded the prestigious American College of Rheumatology Distinguished Fellow Award, as well as a Rheumatology Research Foundation Scientist Development Award.

    Dr. Tambralli cares for children, adolescents, and adults with rheumatic diseases. He looks after all rheumatic diseases and sees patients with inflammatory arthritis, lupus, antiphospholipid syndrome, myositis, vasculitis, and autoinflammatory diseases.

    Dr. Tambralli is also a part of the Jason Knight lab and participates in research on lupus and the antiphospholipid syndrome. He is working towards understanding the metabolic triggers of autoimmunity in these diseases and how to effectively harness them to develop better treatments.

    Qualifications
    • Residency
      University of Rochester Medical Center, Internal Medicine - Pediatrics
    • Fellowship in Adult and Pediatric Rhematology
      University of Michigan–Ann Arbor, Ann Arbor
    • MD
      University of Alabama School of Medicine, Birmingham, AL, 2014
    • BS
      University of Alabama at Birmingham, Birmingham, AL, 2008
    Research Overview

    My research interests are to understand the role of neutrophil metabolism in the pathogenesis of the antiphospholipid syndrome and systemic lupus erythematosus to develop more targeted and less toxic therapies for our patients.

    Recent Publications See All Publications
    • Journal Article
      Insurance Status and Tumor Necrosis Factor Inhibitor Initiation Among Children With Juvenile Idiopathic Arthritis in the CARRA Registry.
      Roberts JE, Williams K, Dallas J, Eckert M, Huie L, Smitherman E, Soulsby WD, Zhao Y, Son MBF, CARRA Registry Investigators . J Rheumatol, 2023 Aug; 50 (8): 1047 - 1057. DOI:10.3899/jrheum.220871
      PMID: 36521922
    • Journal Article
      Interleukin(IL)-1/IL-6-inhibitor-associated drug reaction with eosinophilia and systemic symptoms (DReSS) in systemic inflammatory illnesses.
      Saper VE, Tian L, Verstegen RH, Conrad CK, Cidon M, Hopper RK, Kuo CS, Osoegawa K, Baszis K, Bingham CA, Ferguson I, Hahn T, Horne A, Isupova EA, Jones JT, Kasapcopur Ö, Klein-Gitelman MS, Kostik MM, Ozen S, Phadke O, Prahalad S, Randell RL, Sener S, Stingl C, Abdul-Aziz R, Akoghlanian S, Al Julandani D, Alvarez MB, Bader-Meunier B, Balay-Dustrude EE, Balboni I, Baxter SK, Berard RA, Bhattad S, Bolaria R, Boneparth A, Cassidy EA, Co DO, Collins KP, Dancey P, Dickinson AM, Edelheit BS, Espada G, Flanagan ER, Imundo LF, Jindal AK, Kim H-A, Klaus G, Lake C, Lapin WB, Lawson EF, Marmor I, Mombourquette J, Ogunjimi B, Olveda R, Ombrello MJ, Onel K, Poholek C, Ramanan AV, Ravelli A, Reinhardt A, Robinson AD, Rouster-Stevens K, Saad N, Schneider R, Selmanovic V, Pasic IS, Shenoi S, Shilo NR, Soep JB, Sura A, Taber SF, Tesher M, Tibaldi J, Torok KS, Tsin CM, Vasquez-Canizares N, Villacis Nunez DS, Way EE, Whitehead B, Zemel LS, Sharma S, Fernández-Viña MA, Mellins ED, CARRA Registry Investigators . J Allergy Clin Immunol Pract, 2024 Jul 11; DOI:10.1016/j.jaip.2024.07.002
      PMID: 39002722
    • Journal Article
      Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome.
      Tambralli A, Harbaugh A, NaveenKumar SK, Radyk MD, Rysenga CE, Sabb K, Hurley JM, Sule GJ, Yalavarthi S, Estes SK, Hoy CK, Smith T, Sarosh C, Madison JA, Schaefer JK, Sood SL, Zuo Y, Sawalha AH, Lyssiotis CA, Knight JS. J Clin Invest, 2024 Jun 13; 134 (15): DOI:10.1172/JCI169893
      PMID: 38869951
    • Journal Article
      Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
      NaveenKumar SK, Tambralli A, Fonseca BM, Yalavarthi S, Liang W, Hoy CK, Sarosh C, Rysenga CE, Ranger CH, Vance CE, Madison JA, Orsi FA, Sood SL, Schaefer JK, Zuo Y, Knight JS. Blood, 2024 Mar 21; 143 (12): 1193 - 1197. DOI:10.1182/blood.2023022097
      PMID: 38237140
    • Journal Article
      Health Equity Implications of Missing Data Among Youths With Childhood-Onset Systemic Lupus Erythematosus: A Proof-of-Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.
      Woo JMP, Simmonds F, Dennos A, Son MBF, Lewandowski LB, Rubinstein TB, CARRA Registry investigators . Arthritis Care Res (Hoboken), 2023 Nov; 75 (11): 2285 - 2294. DOI:10.1002/acr.25136
      PMID: 37093036
    • Journal Article
      Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice.
      Liu C, Yalavarthi S, Tambralli A, Zeng L, Rysenga CE, Alizadeh N, Hudgins L, Liang W, NaveenKumar SK, Shi H, Shelef MA, Atkins KB, Pennathur S, Knight JS. Sci Adv, 2023 Oct 27; 9 (43): eadj1019 DOI:10.1126/sciadv.adj1019
      PMID: 37878711
    • Journal Article
      Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps.
      Kmeťová K, Lonina E, Yalavarthi S, Levine JS, Hoy CK, Sarosh C, Gockman K, Morris AE, Tambralli A, Madison JA, Zuo Y, Subang R, Rauch J, Knight JS. Clin Immunol, 2023 Oct; 255: 109714 DOI:10.1016/j.clim.2023.109714
      PMID: 37527733
    • Journal Article
      Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care.
      Smitherman EA, Chahine RA, Beukelman T, Lewandowski LB, Rahman AKMF, Wenderfer SE, Curtis JR, Hersh AO, CARRA Registry Investigators . Arthritis Care Res (Hoboken), 2023 Jul; 75 (7): 1553 - 1562. DOI:10.1002/acr.25002
      PMID: 36775844
    Featured News & Stories blood vial blue yellow
    Health Lab
    Could targeting metabolism treat blood clots in antiphospholipid syndrome? 
    A research team is investigating how metabolism – the process by which cells turn sugars, fats and proteins into energy – is used to make NETs in regards to antiphospholipid syndrome.
    What I'm Reading in APS Research
    Research News
    What I'm reading in APS research | June 2024
    What I’m Reading in APS Research, written by Dr. Ajay Tambralli and Dr. Jason Knight, was created to provide information about some of the latest APS research and to help everyone better understand the ins and outs of these publications. In this month’s edition, Dr. Knight highlights several abstracts presented at the annual EULAR Congress.