Alexey I Nesvizhskii, PhD

Alexey Nesvizhskii, Ph.D., is the Godfrey Dorr Stobbe Professor of Bioinformatics. He received his M.S. degree (with honors) from St. Petersburg State Technical University, Department of Physics and Technology, St. Petersburg, Russia in 1995 and Ph.D. degree in Physics from the University of Washington, Seattle, USA, in 2001. He then completed post-doctoral training in the area of bioinformatics and proteomics in Ruedi Aebersold Lab at the Institute for Systems Biology in Seattle, Washington from 2001-2003, and joined the staff as a Research Scientist upon completion of training. He joined the faculty at the University of Michigan in November of 2005.

Dr. Nesvizhskii has published more than 120 manuscripts in international scientific journals. In 2007, he was named a "Rising Young Investigator" by Genome Technology magazine (USA). Dr. Nesvizhskii serves as Senior Editor in the area of bioinformatics and biostatistics for international journals Proteomics and Proteomics-Clinical Applications, as Section Editor in the area of proteomics for BMC Bioinformatics, and on the Editorial Boards of Molecular and Cellular Proteomics. Dr. Nesvizhskii also serves on the Scientific Advisory Board for the Swiss Institute of Bioinformatics and on the Board of Directors for the US Human Proteome Organization. He is frequently invited to present his research at seminars and conferences in the United States and internationally, and to serve on grant review panels.

As an enthusiastic educator, Dr. Nesvizhskii directs the NIH funded T32 Proteome Informatics of Cancer Training Program at the University of Michigan, and teaches graduate-level courses in the area of bioinformatics, proteomics, and systems biology. In addition, he has developed and taught several internationally recognized hands-on workshops and tutorials. His educational efforts have been recognized by several awards, including induction in the League of Educational Excellence at the University of Michigan Medical School.

Dr. Nesvizhskii's research laboratory is working in the area of bioinformatics, proteomics, and systems biology. The computational tools previously developed by Dr. Nesvizhskii and his colleagues, such as Trans-Proteomic Pipeline (including PeptideProphet and ProteinProphet), PeptideAtlas, SAINT, CRAPome, and DIA-Umpire are among the most cited proteome bioinformatics tools and used by hundreds of laboratories worldwide. Over the past several years, he has extended his studies to other omics data such as RNA-Seq transcriptomics, with a focus on alternative splicing and sense-antisense transcription. His lab actively collaborates with technology developers, biologists, and clinical scientists on a variety of projects, including analysis protein interaction networks and complexes, label-free proteome quantification, integrative modeling of multi-omics data to reconstruct targetable pathways in cancer, and biomarker discovery. Dr. Nesvizhskii directs the Proteomics Resource Facility in the Department of Pathology which aims to provide cutting-edge proteomics capability to investigators at the University of Michigan.