Chase A Weidmann

 Chase A. Weidmann
Assistant Professor of Biological Chemistry
Medical School
[email protected]
Available to mentor
Chase A Weidmann
Chase A. Weidmann
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

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    • Qualifications
    • Postdoctoral Scholar/Staff Scientist
      Washington University in St. Louis School of Medicine, Cell Biology and Physiology, St Louis, United States
      2020 - 2021
      Postdoctoral Research
    • Postdoctoral Fellow
      University of North Carolina at Chapel Hill, Chemistry, United States
      2015 - 2020
      Postdoctoral Fellowship
    • Ph.D. in Biological Chemistry
      University of Michigan, Ann Arbor, MI, United States
      2009 - 2015
    • B.S. in Biochemistry
      University of Rochester, Rochester, NY, United States
      2005 - 2009

    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center

    Research Overview

    We are interested in how cellular signals are propagated through interactions between RNA and protein, and how these interaction networks malfunction during cancer and disease. While most of the human genome is transcribed into RNA, only a small portion (< 5%) encodes protein; the remainder of the transcriptome includes many classes of small and large noncoding RNAs whose mechanisms are not fully understood. Our vision is to leverage RNA and protein sequencing and imaging technologies to characterize RNA-protein interaction networks and generate novel therapeutic strategies that target protein interaction sites on RNA.

    Links
    • Website

    Recent Publications

     See All Publications
    • Journal Article
      Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.
      Ruan M, Engels SM, Burroughs MR, Li X, Stower R, Tzadikario T, Powell C, Bloch D, Fanari O, Akeson S, Eyler DE, Weidmann CA, Rouhanifard S, Jain M, Contreras LM, Koutmou KS. Nat Commun, 2026 Apr 17; DOI:10.1038/s41467-026-71654-y
      PMID: 41997936
    • Journal Article
      Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells
      Saleem I, Miller T, Kearns L, Hoang A, Meehan J, Bose R, Mitchell D, Price DH, Olson CM, Weidmann CA, Mustoe AM. Molecular Cell, 2026 Jan 1; DOI:10.1016/j.molcel.2026.03.029
    • Journal Article
      SHAPE-Based Chemical Probes for Studying preQ1–RNA Interactions in Living Bacteria
      Reyes Franceschi JA, Cárdenas EL, Klein BJC, Weidmann CA, Garner AL. ACS Chemical Biology, 2025 Nov 21; 20 (11): 2689 - 2697. DOI:10.1021/acschembio.5c00548
      PMID: 41073353
    • Preprint
      Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance.
      Ruan M, Engels SM, Burroughs MR, Li X, Stower R, Tzadikario T, Powell C, Bloch D, Fanari O, Akeson S, Eyler DE, Weidmann CA, Rouhanifard S, Jain M, Contreras LM, Koutmou KS. 2025 Sep 22; DOI:10.1101/2025.09.22.675887
      PMID: 41040199
    • Journal Article
      Functional Proximity across an mRNA
      Hatfield BM, Weidmann CA, McCutchin CA, Irving PS, Nelson IM, Felder S, Weeks KM. Biochemistry, 2025 Sep 16; 64 (18): 3854 - 3865. DOI:10.1021/acs.biochem.5c00340
      PMID: 40792674
    • Preprint
      SHAPE-based chemical probes for studying preQ1-RNA interactions in living bacteria.
      Franceschi JAR, Cárdenas EL, Klein BJC, Weidmann CA, Garner AL. 2025 Jul 21; DOI:10.1101/2025.07.21.665968
      PMID: 40777364
    • Journal Article
      A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes
      Hao X, Chen Y, Sahu D, Przanowska RK, Aaiyas M, Weidmann CA, Nardi I, Weeks KM, Dutta A. Journal of Biological Chemistry, 2025 Jun 1; 301 (6): DOI:10.1016/j.jbc.2025.110172
      PMID: 40320073
    • Preprint
      A 36-base hairpin within lncRNA DRAIC , which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes.
      Hao X, Chen Y, Sahu D, Przanowska RK, Aaiyas M, Weidmann CA, Nardi I, Weeks KM, Dutta A. 2025 Apr 25; DOI:10.1101/2024.12.23.629241
      PMID: 39764029

    Featured News & Stories

         2025 Endowment for Basic Sciences Awards
    Medical School News

    Eighteen from UMMS honored with 2025 Endowment for Basic Sciences Awards

    Nine Medical School faculty members and nine research staff members have been recognized for their contributions to teaching and research with Endowment for Basic Sciences (EBS) Awards for 2025. Each of the nine UMMS basic science departments select a winner for each award. This year’s recipients received their awards June 12 during a ceremony in the Medical School.
         Headshots of EBS awardwinners with trophy
    Department News

    Chase Weidmann and Daniel Esckilsen receive Endowment for Basic Sciences Awards

    Assistant Professor Chase Weidmann and Research Lab Specialist Daniel Esckilsen are the 2025 recipients of Endowment for Basic Sciences (EBS) Awards for the Department of Biological Chemistry at U-M Medical School.
         Chase Weidmann onstage, receiving a faculty mentor award
    Department News

    Chase Weidmann, PhD, receives the 2024 Outstanding Faculty Mentor Award from the Cellular and Molecular Biology Program

    Assistant Professor Chase Weidmann of the Department of Biological Chemistry at U-M Medical School is the 2024 recipient of the Outstanding Faculty Mentor Award from the CMB Program.