David K Jones

 headshot of Dave Jones
Pfizer Upjohn Early Career Research Professor of Pharmacology
Assistant Professor of Pharmacology
Assistant Professor of Internal Medicine
Medical School
[email protected]
Available to mentor
David K Jones
headshot of Dave Jones
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

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    • Qualifications
    • K99 Fellowship
      University of Wisconsin-Madison, Neuroscience, United States
      2018 - 2019
      Predoctoral Fellowship
    • Stem Cell and Regenerative Medicine
      University of Wisconsin-Madison, Neuroscience, United States
      2016 - 2018
      Postdoctoral Fellowship
    • Postdoctoral Fellow
      University of Wisconsin, Cardiac Electrophysiology, Madison, Wisconsin, United States
      2012 - 2018
      Postdoctoral Fellowship
    • Translational Cardiovascular Science
      University of Wisconsin-Madison, Neuroscience, United States
      2014 - 2016
      Postdoctoral Fellowship
    • Cardiovascular Research Center Postdoctoral Award T32 HL007936
      University of Wisconsin, Madison, United States
      2012 - 2014
      Postdoctoral Fellowship
    • Certificate
      Simon Fraser University, University Teaching, Burnaby, Canada
      2009 - 2010
      Postdoctoral Fellowship

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Frankel Institute for Heart and Brain Health

    Research Overview

    Mechanisms and of cardiac arrhythmia and dysfunction in the developing heart.
    Allosteric modulation of potassium channel gating to treat diseases of cardiac excitability.
    Neuronal comorbidities of cardiac electrical dysfunction.

    Links
    • Jones Lab

    Recent Publications

     See All Publications
    • Journal Article
      hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (IKr) in cardiomyocytes derived from hiPSCs.
      Ukachukwu CU, Jimenez-Vazquez EN, Jain A, Jones DK. J Biol Chem, 2023 Feb; 299 (2): 102778 DOI:10.1016/j.jbc.2022.102778
      PMID: PMC9867984
    • Journal Article
      KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression
      Jain A, Stack O, Ghodrati S, Sanchez-Conde FG, Ukachukwu CU, Salwi S, Jimenez-Vazquez EN, Jones DK. Proceedings of the National Academy of Sciences of the United States of America, 2023 Jan 17; 120 (3): DOI:10.1073/pnas.2214700120
      PMID: 36626562
    • Journal Article
      Enhancing iPSC-CM Maturation Using a Matrigel-Coated Micropatterned PDMS Substrate
      Jimenez-Vazquez EN, Jain A, Jones DK. Current Protocols, 2022 Nov 1; 2 (11): DOI:10.1002/cpz1.601
      PMID: 36383047
    • Journal Article
      The ERG1 K+ Channel and Its Role in Neuronal Health and Disease
      Sanchez-Conde FG, Jimenez-Vazquez EN, Auerbach DS, Jones DK. Frontiers in Molecular Neuroscience, 2022 May 3; 15: DOI:10.3389/fnmol.2022.890368
    • Preprint
      Acute Exposure to Perfluorooctanoic Acid (PFOA) During Cardiomyogenesis disrupts Transcriptional and Electrophysiological Profiles in Differentiated Myocytes
      Ishikawa T, Clark CW, Tapaswi A, Sala-Hamrick KE, Herron TJ, Jimenez-Vazquez EN, Jain A, Jones DK, Colacino J, Monteiro Da Rocha A, Svoboda LK. 2026 May 10; bioRxiv, DOI:10.64898/2026.05.05.723050
    • Journal Article
      Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1.
      Sanchez-Conde FG, Goodrich MR, Stack OM, Goldberg LNR, Ruzycki PK, Jain A, Jimenez-Vazquez EN, Jones DK. J Biol Chem, 2026 Feb 16; 111296 DOI:10.1016/j.jbc.2026.111296
      PMID: 41708004
    • Preprint
      Sudden Death-Associated KCNH2 Variants Have Opposing Effects on hERG1NP Function.
      Sanchez-Conde FG, Goodrich M, Stack O, Goldberg L, Ruzycki P, Jain A, Jimenez-Vazquez EN, Jones DK. 2025 Oct 24; DOI:10.1101/2025.10.23.684168
      PMID: 41279916
    • Presentation
      Mechanisms regulating hERG1NP physiology and pathophysiology
      Jones D. 2025 Jul 16;

    Featured News & Stories
    Department News

    David Jones receives Elizabeth Caroline Crosby Grant

    David Jones, PhD, Assistant Professor of Pharmacology and Assistant Professor of Internal Medicine, has been awarded the Elizabeth Caroline Crosby Grant.