James H Morrissey
Professor of Biological Chemistry
Professor of Internal Medicine
Dept. of Biological Chemistry
Room 4301B MSRB III, 1150 West Medical Center Drive
Ann Arbor, MI 48109
[email protected]

Available to mentor

James H Morrissey
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    My lab's research focuses on understanding how the human blood clotting system functions in health (normal hemostasis) and disease (thrombosis). In particular, we conduct biochemical studies aimed at elucidating the underlying mechanisms controlling the complex series of enzyme-activation events that make up the blood clotting cascade, which lead ultimately to the formation of a fibrin clot and activated platelets. Thrombosis is the formation of unwanted blood clots inside arteries and veins, which represents one of the leading causes of disability and death worldwide. For this reason, it is critically important to understand how the the blood coagulation is regulated. My lab's research program is a combination of basic and translational research.

    Links
    • Morrissey lab web site
    • linkedin
    • Google Scholar
    • Curriculum vitae (CV) for Jim Morrissey
    • twitter
    Qualifications
    • PhD
      University of California, San Diego, La Jolla, 1980
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    We are currently focusing on the following research questions:
    -- How do the serine proteases of the blood clotting system assemble together with specific regulatory proteins on membrane surfaces?
    -- These enzyme activation events are thousands of times less active in solution than on membrane surfaces. Why are membranes required for efficient proteolysis by these enzymes? What role do specific phospholipid types play in modulating the activity of blood clotting proteases?
    -- We recently discovered that inorganic polyphosphate (secreted from activated platelets and abundant in many microorganisms) is a novel and highly potent modulator of blood clotting and fibrinolysis. It is also proinflammatory. What are the mechanisms by which polyphosphate exerts these biologic activities?

    Recent Publications See All Publications
    • Journal Article
      External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote.
      La CC, Smith SA, Kalathottukaren MT, Haynes CA, Morrissey JH, Kizhakkedathu JN. Adv Healthc Mater, 2024 Aug; 13 (20): e2400108 DOI:10.1002/adhm.202400108
      PMID: 38537246
    • Journal Article
      Antipolyphosphate monoclonal antibodies derived from autoimmune mice.
      Sedzro JC, Smith SA, Scott A, Wang Y, Travers RJ, Hemp R, Morse CN, Morrissey JH. Res Pract Thromb Haemost, 2024 Aug; 8 (6): 102550 DOI:10.1016/j.rpth.2024.102550
      PMID: 39309228
    • Journal Article
      HRG to the Rescue.
      Morrissey JH. Arterioscler Thromb Vasc Biol, 2024 Jul; 44 (7): 1671 - 1673. DOI:10.1161/ATVBAHA.124.321178
      PMID: 38924441
    • Journal Article
      INHIBITORS OF INORGANIC POLYPHOSPHATE AND NUCLEIC ACIDS ATTENUATE IN VITRO THROMBIN GENERATION IN PLASMA FROM TRAUMA PATIENTS.
      MacArthur TA, Goswami J, Navarro SM, Vappala S, La CC, Yudin N, Zietlow J, Smith SA, Morrissey JH, Spears GM, Bailey KR, Dong J-F, Kozar RA, Kizhakkedathu JN, Park MS. Shock, 2024 Jun 1; 61 (6): 848 - 854. DOI:10.1097/SHK.0000000000002362
      PMID: 38662595
    • Journal Article
      Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.
      Hajeyah AA, Protty MB, Paul D, Costa D, Omidvar N, Morgan B, Iwasaki Y, McGill B, Jenkins PV, Yousef Z, Allen-Redpath K, Soyama S, Choudhury A, Mitra R, Yaqoob P, Morrissey JH, Collins PW, O'Donnell VB. J Lipid Res, 2024 Jan; 65 (1): 100484 DOI:10.1016/j.jlr.2023.100484
      PMID: 38103786
    • Journal Article
      Looking Back-And Forward.
      Lillicrap D, Morrissey JH. J Thromb Haemost, 2023 Dec; 21 (12): 3285 - 3286. DOI:10.1016/j.jtha.2023.09.024
      PMID: 38000849
    • Journal Article
      Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.
      La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. Nat Commun, 2023 Apr 26; 14 (1): 2177 DOI:10.1038/s41467-023-37709-0
      PMID: 37100783
    • Journal Article
      Lactadherin's Multistate Binding Predicts Stable Membrane-Bound Conformations of Factors V and VIII's C Domains.
      Cheng KJ, De Lio AM, Jain R, Paul D, Morrissey JH, Pogorelov TV. Biochemistry, 2023 Oct 17; 62 (20): 3020 - 3032. DOI:10.1021/acs.biochem.3c00274
      PMID: 37747791
    Featured News & Stories Headshot of Dr. James Morrissey alongside photo of his 2024 award from UM Cardiovascular Research Network
    Department News
    Congratulations to James Morrissey, PhD, and his research team for recent achievements
    Recent achievements from the Morrissey lab in the Department of Biological Chemistry at UM Medical School.