Paulette Goforth

 headshot of Paula Goforth
Assistant Professor of Pharmacology
Medical School
University of Michigan Medical School
Department of Pharmacology
Ann Arbor, MI
[email protected]
Available to mentor
Paulette Goforth
headshot of Paula Goforth
Assistant Professor
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  • Qualifications
  • Center Memberships
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    • About

    The Goforth Lab investigates the mechanisms by which the brain integrates information from periphery to regulate physiology and behavior. We focus on neural circuits in the hypothalamus and hindbrain that control feeding, energy balance, motivation, and mood. A central goal of the lab is to understand how dysregulation of these circuits contributes to obesity, substance use disorder, anxiey and depression.

    Links
    • Lab website

    Qualifications
    • Postdoctoral Fellow
      Virginia Commonwealth University School of Medicine, Pharmacology, Richmond, VA, United States
      2000 - 2004
      Postdoctoral Research

    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Frankel Institute for Heart and Brain Health

    Recent Publications

     See All Publications
    • Journal Article
      Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity.
      Dell'Orco J, Pan W, Allison MB, Tomlinson AJ, Wean J, Sabatini PV, Rhodes CJ, Olson DP, Myers MG, Goforth PB. Mol Metab, 2026 May 2; 102378 DOI:10.1016/j.molmet.2026.102378
      PMID: 42082152
    • Proceeding / Abstract / Poster
      Elevated Leptin Alters Calcium Channel Expression and Promotes the Hyperexcitability of LepRb Neurons in Diet-Induced Obese Mice
      Dell'Orco J, Duensing A, Affinati A, Paul S, Myers M, Goforth P. 2024 Feb 7;
    • Presentation
      Imaging, Cell Physiology and Metabolism
      2023 Jan 26;
    • Proceeding / Abstract / Poster
      Regulation of Glp-1 receptor and GPR10-expressing neurons in the mouse area postrema
      Goforth P, Bhagat R, Connaughton C, Olson D. 2022 Nov 26;
    • Proceeding / Abstract / Poster
      Regulation of glucagon-like peptide 1 receptor neurons in the area postrema
      Bhagat R, Arnold K, Connaughton C, Olson D, Goforth P. 2022 May 26;
    • Journal Article
      Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal.
      Sutton Hickey AK, Goforth PB, Gonzalez IE, Dell'Orco J, Pei H, Myers MG, Olson DP. Proc Natl Acad Sci U S A, 2021 Apr 13; 118 (15): DOI:10.1073/pnas.2103090118
      PMID: PMC8053962
    • Journal Article
      Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin
      Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG. Journal of Clinical Investigation, 2020 Jun 1; 130 (6): 2943 - 2952. DOI:10.1172/JCI134135
      PMID: 32134398
    • Presentation
      Brain Games: manipulating and monitoring neuronal activity
      2023 Jan 26;

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