Puwen Tan, PhD
Postdoctoral Fellow | Au lab
Research Interests
My research interests focus on applying computational methods to explore the roles of transposable elements (TEs) in early embryonic development and stem cell differentiation. By employing cutting-edge long-read sequencing technologies, including PacBio and Oxford Nanopore Technology, I aim to decipher the complexities of post-transcriptional regulatory networks during early embryogenesis. Through my work, I aspire to contribute to a deeper understanding of the molecular intricacies orchestratin
Related News & Stories
Department News
The Au lab developed a computational method that combines short- and long- RNA sequencing reads to study gene isoforms
Professor Kin Fai Au and his lab members Xiaoyu Cai, Qi Gao, Haoran Li, Puwen Tan, Dingjie Wang, and Yunhao Wang, with partners from Ohio State University, developed a new software that improves the accuracy of the quantification of gene isoforms for complex genes. Their software, called miniQuant, ranks genes with the uncertainty of isoform quantification. It integrates the complementary strengths of long reads and short reads of RNA sequencing data with optimal combinations in a gene- and data-specific manner to achieve more accurate isoform quantification. These findings are published in Nature Biotechnology.
