Shyamal Mosalaganti, PhD
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About
Shyamal Mosalaganti was born and brought up in India. He earned his bachelor's and master's degrees in chemistry from the Sri Sathya Sai Institute of Higher learning, India. He then moved to the Max Planck Institute of Molecular Physiology in Dortmund, Germany, on an International Max Planck Research Fellowship to study the structure and function of membrane proteins in the lab of Stefan Raunser. During his Ph.D. program, he also worked in collaboration with the group of Andrea Musacchio to elucidate the architecture of the components of human kinetochore.
Inspired by the revolution in cryo-electron microscopy, Mosalaganti continued his postdoctoral research work in understanding the architecture of protein complexes in near-native environments (in-situ structural biology). In the lab of Martin Beck at the European Molecular Biology Laboratory, his work led to mapping the symmetric core of the human nuclear pore complex.
In his lab at the U-M Life Sciences Institute, Mosalaganti continues to provide structural snapshots of macromolecular complexes in-situ, with a special focus on understanding lysosomal function, positioning and inter-organelle crosstalk.
Qualifications
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Postdoctoral FellowEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany
2015 - 2020
Postdoctoral Fellowship
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Postdoctoral FellowMax Planck Institute of Molecular Physiology, Department of Structural Biochemistry, Dortmund, Germany
2014 - 2015
Postdoctoral Fellowship
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Project AssociateIndian Institute of Science, Department of Biochemistry, Bangalore, India
2007 - 2009
Postdoctoral Fellowship
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Ph.D.Max Planck Institute of Molecular Physiology, Dortmund, Germany
2009 - 2014
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M.Sc. in ChemistrySri Satya Sai Institute of Higher Learning, Puttaparthi, India
2005 - 2007
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B.Sc. ChemistrySri Satya Sai Institute of Higher Learning, Bengaluru, India
2002 - 2005
Research Overview
My laboratory is interested in understanding how membrane-enclosed structures within our cells perform their jobs to maintain cell health. We are particularly interested in lysosomes, which not only play an important role in cellular 'waste management,' but also serve as a key decision-making center controlling cellular growth and survival. My lab combines state-of-the-art cryo-electron microscopy/tomography and correlative microscopy approaches with biochemical and cell biology methods to elucidate how lysosomes perform their functions and engage in clearance of pathological aggregates, transport ions and metabolites and play indispensible roles in maintaining cellular homeostasis.
Recent Publications
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Replogle JM, Marks JD, Fernandez MG, Yuan H, Yu D, Winters E, Jawahar VM, Deshmukh R, Sutanto R, Kowal I, Frankenfield A, Shi R, Carlomagno Y, Jansen-West K, Todd TW, Kopach A, Sandra Ndayambaje I, Qi YA, Shantaraman A, Pozo-Cabanell I, Sheth U, Yue M, Duong D, Ferguson SM, Bennett DA, Damme M, Boeve BF, Day GS, Kellman B, Skarnes WC, Petersen RC, Josephs KA, Graff-Radford NR, McDonough JA, Prudencio M, Barmada SJ, Zhang Y, Hao L, DeTure M, Rawlinson B, Engelberg-Cook E, Casey MC, Perez N, Dickson DW, Wingo A, Liu Y, Seyfried NT, Wingo TS, Mosalaganti S, Petrucelli L, Ward ME. 2026 Mar 28;PreprintNeurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.
DOI:10.64898/2026.03.26.714634 PMID: 41929000 -
Mosalaganti S. 2026 May 28;PresentationTBD
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Connelly SM, Bergner L, Tiwari A, Brant TS, Medford S, Ramesh S, Tidwell ED, Yoo Y, Xiao K, Gentry J, Chang L, Han B, Rangamani P, Doktorova M, Kenworthy AK, Mosalaganti S, Ohi MD. 2026 Feb 17;PreprintStructural basis of caveolin-driven membrane bending.
DOI:10.64898/2026.02.05.703862 PMID: 41717096 -
Mosalaganti S. 2026 May 28;PresentationTBD
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Xie W, Gowder M, Bazzano D, Shami AN, Pandey A, Frasca M, Paniker L, de Almeida LP, Bharati BK, Liang J, Tóth A, DeSantis M, Nandakumar J, Nudler E, Mosalaganti S, Pezza R, Cole F, Hammoud SS. 2026 Feb 2;PreprintZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements.
DOI:10.64898/2026.01.30.702899 PMID: 41676639 -
Badieyan S, Gentry J, Fernandez MG, Gicking AM, Hancock WO, Mosalaganti S, Cianfrocco MA. Biophysical Journal, 2026 Feb 21; 125 (4): 37aProceeding / Abstract / PosterBPS2026 – Architecture of HIV-1 capsid bound to the dynein transport machinery
DOI:10.1016/j.bpj.2025.11.397 -
Bhattacharyya M, Kumar S, Jung H, Walker G, Rana J, Fu R, Hong M, Malerba F, Kumar J, Navratna V, Kruckenhauser LM, Garg S, Cattaneo A, Krishnan Y, Mosalaganti S. Biophysical Journal, 2026 Feb 21; 125 (4): 95aProceeding / Abstract / PosterBPS2026 – Molecular mechanism of pain perception by regulation of receptor tyrosine kinase TrkA
DOI:10.1016/j.bpj.2025.11.768 -
Ma Q, Hernandez CC, Navratna V, Kumar A, Rana JK, Zong J, Lee A, Mosalaganti S. Nat Commun, 2026 Jan 31; 17 (1):Journal ArticleInsights into the structure and modulation of human TWIK-2.
DOI:10.1038/s41467-026-69072-1 PMID: PMC12960705
Featured News & Stories
New Publication led by Dr. Subhash Arya (Parent Lab) in close collaboration with the Coulombe and Mosalaganti Labs!
