Uhn-Soo Cho, PhD

 Uhn-Soo Cho
Associate Professor of Biological Chemistry
Medical School
University of Michigan Medical School
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220E MSRB III
Ann Arbor, MI 48109
[email protected]
Available to mentor
Uhn-Soo Cho, PhD
Uhn-Soo Cho
Associate Professor
  • Qualifications
  • Research Overview
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    • Qualifications
    • HHMI Postdoctoral Fellow
      Harvard Medical School, Boston, United States
      2007 - 2012
      Postdoctoral Fellowship
    • PhD
      University of Washington, Seattle, WA, 98195, United States
      2002 - 2007
    • MS
      Korea University, Seoul, Korea, Republic Of
      1998 - 2000
    • BS
      Korea University, Seoul, Korea, Republic Of
      1991 - 1998

    Research Overview

    Our laboratory is interested in illustrating the molecular mechanisms of key biological events, particularly epigenetic regulation and metabolic homeostasis, using structural biology as major tools. We use X-ray crystallography and cryogenic electron microscopy to determine the atomic level of macromolecular structures to understand its mechanisms.

    Links
    • The Cho laboratory

    Recent Publications

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    • Journal Article
      Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model
      Wang Y, Yu L, Deng K, Packiarajan M, Aguilar A, An S, Liu X, Myers G, Oh H, Singh SA, Cho US, Wang S, Guan Y, White AD, Khoriaty R, Engel JD. Blood, 2025 Jul 17; 146 (3): 356 - 368. DOI:10.1182/blood.2024028006
      PMID: 40332031
    • Preprint
      The graphene-based affinity cryo-EM grid for the endogenous protein structure determination.
      An S, Ahn E, Koo T, Park S, Suh B, Rengasamy KP, Lyu G, Kim C, Kim B, Kim H, Park S, Tan D, Cho U-S. 2025 Feb 26; DOI:10.1101/2025.02.22.638683
      PMID: 40060550
    • Journal Article
      Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex
      Porter RS, An S, Gavilan MC, Nagai M, Murata-Nakamura Y, Zhou B, Bonefas KM, Dionne O, Manuel JM, St-Germain J, Gascon S, Kim J, Browning L, Laurent B, Cho US, Iwase S. Cell Reports, 2025 Jan 28; 44 (1): DOI:10.1016/j.celrep.2024.115213
      PMID: 39817906
    • Journal Article
      Structural basis for Mis18 complex assembly and its implications for centromere maintenance
      Thamkachy R, Medina-Pritchard B, Park SH, Chiodi CG, Zou J, de la Torre-Barranco M, Shimanaka K, Abad MA, Gallego Páramo C, Feederle R, Ruksenaite E, Heun P, Davies OR, Rappsilber J, Schneidman-Duhovny D, Cho US, Jeyaprakash AA. EMBO Reports, 2024 Aug 9; 25 (8): 3348 - 3372. DOI:10.1038/s44319-024-00183-w
      PMID: 38951710
    • Book
      The Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome
      Cho U-S. 2024 Jul 9; DOI:10.1007/978-3-031-58843-3_6
    • Journal Article
      The Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome
      Cho US. 2024 Jan 1; 104: 101 - 117. DOI:10.1007/978-3-031-58843-3_6
      PMID: 38963485
    • Journal Article
      Non-canonical MLL1 activity regulates centromeric phase separation and genome stability
      Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz HJ, An W, Cho US, Dou Y. Nature Cell Biology, 2023 Nov 1; 25 (11): 1637 - 1649. DOI:10.1038/s41556-023-01270-1
      PMID: 37945831
    • Preprint
      A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A.
      Porter RS, Nagai M, An S, Gavilan MC, Murata-Nakamura Y, Bonefas KM, Zhou B, Dionne O, Manuel JM, St-Germain J, Browning L, Laurent B, Cho U-S, Iwase S. 2024 Jun 2; DOI:10.1101/2023.10.20.563357

    Featured News & Stories
    Department News

    Cho lab publishes research article in ACS Nano

    The Cho lab published a research article in ACS Nano.