Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
[email protected]
Available to mentor
Yuanfang Guan, PhD
Professor
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Ph.D., Molecular BiologyPrinceton University, Princeton, NJ, 2010
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BS, BiologyThe University of Hong Kong, Hong Kong, 2005
The Guan lab's research focus is machine learning in biology and medical fields.
Guan Lab
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Salcedo A, Tarabichi M, Buchanan A, Espiritu SMG, Zhang H, Zhu K, Ou Yang T-H, Leshchiner I, Anastassiou D, Guan Y, Jang GH, Mootor MFE, Haase K, Deshwar AG, Zou W, Umar I, Dentro S, Wintersinger JA, Chiotti K, Demeulemeester J, Jolly C, Sycza L, Ko M, PCAWG Evolution and Heterogeneity Working Group , SMC-Het Participants , Wedge DC, Morris QD, Ellrott K, Van Loo P, Boutros PC. Nat Biotechnol, 2024 Jun 11;Journal ArticleCrowd-sourced benchmarking of single-sample tumor subclonal reconstruction.
DOI:10.1038/s41587-024-02250-y PMID: 38862616 -
Deng K, Schwendeman PS, Guan Y. Adv Sci (Weinh), 2024 Apr; 11 (15): e2305626Journal ArticlePredicting Single Neuron Responses of the Primary Visual Cortex with Deep Learning Model.
DOI:10.1002/advs.202305626 PMID: 38350735 -
Schuster KH, Zalon AJ, DiFranco DM, Putka AF, Stec NR, Jarrah SI, Naeem A, Haque Z, Zhang H, Guan Y, McLoughlin HS. Mol Ther, 2024 May 1; 32 (5): 1359 - 1372.Journal ArticleASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice.
DOI:10.1016/j.ymthe.2024.02.033 PMID: 38429929 -
Dang X, Li W, Zou J, Cong B, Guan Y. iScience, 2024 Feb 16; 27 (2): 108626Journal ArticleAssessing the impact of body location on the accuracy of detecting daily activities with accelerometer data.
DOI:10.1016/j.isci.2023.108626 PMID: 38318391 -
Lin C-X, Guan Y, Li H-D. Curr Opin Struct Biol, 2024 Feb; 84: 102747Journal ArticleArtificial intelligence approaches for molecular representation in drug response prediction.
DOI:10.1016/j.sbi.2023.102747 PMID: 38091924 -
Zhang H, Wang Z, Nan Y, Zagidullin B, Yi D, Tang J, Guan Y. Commun Biol, 2023 Apr 11; 6 (1): 397Journal ArticleHarmonizing across datasets to improve the transferability of drug combination prediction.
DOI:10.1038/s42003-023-04783-5 PMID: 37041243 -
Zhang H, Kreis J, Schelhorn S-E, Dahmen H, Grombacher T, Zühlsdorf M, Zenke FT, Guan Y. Nat Commun, 2023 Dec 14; 14 (1): 8310Journal ArticleMapping combinatorial drug effects to DNA damage response kinase inhibitors.
DOI:10.1038/s41467-023-44108-y PMID: 38097586 -
Zheng J-W, Lu Y, Yang Y-F, Huang D, Li D-W, Wang X, Gao Y, Yang W-D, Guan Y, Li H-Y. BMC Genomics, 2023 Oct 9; 24 (1): 598Journal ArticleSystematic dissection of genomic features determining the vast diversity of conotoxins.
DOI:10.1186/s12864-023-09689-4 PMID: 37814244
Department News
Five DCMB faculty were promoted. They are Yuanfang Guan, Ph.D., Jie Liu, Ph.D., Ryan Mills, Ph.D., Stephen C.J. Parker, Ph.D., and Arvind Rao, Ph.D. Congratulations!