CPOD Faculty Publication Spotlight - Hammoud Lab

Tower CA, Manske G, Ferrell EL, Anbarci DN, Jorgensen K, Ma B, Aboelenain M, Ranjan R, Chakraborty S, Moritz L, Das A, Boiani M, Black BE, Chavez S, Marsh EE, Shikanov A, Schindler K, Chen X, Hammoud SS. Developmental Cell. 2025 September 24. Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation.

From the Publication:

“Chromosome segregation errors are common in early embryos and are a significant source of aneuploidy. This study shows that mammalian gametes contribute asymmetric levels of the centromere protein CENP-A, which the embryo must actively equalize prior to the first division to ensure accurate chromosome segregation. These findings reveal a previously unrecognized centromere quality-control mechanism operating at fertilization.”

Pictured from Dr. Hammoud's Lab