CPOD Faculty Publication Spotlight - Shah Lab

Immunofluorescence staining for ACSL4 (red), PDGFRα (green) and Hoechst (blue) in colon tissue from IBD mouse model.

Huang W, Zhang Y, Das NK, Solanki S, Jain C, El-Derany MO, Koo I, Bell HN, Aabed N, Singhal R, Castillo C, Buscher K, Ying Y, Dimitroff J, Sharma A, Shi J, Hogan SP, Dame MK, Higgins PDR, Colacino JA, Oh TG, Spence JR, Patterson AD, Greenberg AS, Greenson JK, Nusrat A, Shah YM. Nature Metabolism. 2025 June 26. Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD.

Immunofluorescence staining for ACSL4 (red), PDGFRα (green) and Hoechst (blue) in colon tissue from IBD mouse model.
Immunofluorescence staining for ACSL4 (red), PDGFRα (green) and Hoechst (blue) in colon tissue from IBD mouse model.

From the publication: 

"Here we show that lipid peroxidation contributes to the pathophysiology of inflammatory bowel disease (IBD) by promoting ferroptosis, an iron-dependent form of programmed cell death. Mechanistically, we explored how fibroblast-driven lipid remodeling can influence epithelial vulnerability to ferroptosis, offering new insights into the cellular crosstalk that shapes intestinal inflammation in IBD."  

Pictured from Dr. Shah's Lab

Wesley Huang, PhD
Author Wesley Huang, PhD

 

Yuezhong Diana Zhang, Graduate Student, and Dr. Yatrik Shah, PhDProfessor of Molecular & Integrative Physiology and Internal Medicine
Yuezhong Diana Zhang, Graduate Student, and author Dr. Yatrik Shah, PhD, Professor of Molecular & Integrative Physiology and Internal Medicine

 

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