Rising Neurology Drug Costs

Researchers looked at medication cost trends for the five most common neurologic conditions.

Author | Shoshanna Fischhoff

prescription pills spilling out of a bottle on a pile of money

Prescription drug prices are an issue on many American’s minds.  On average, Americans spend $1,432 a year, and approximately one in three cannot take medications as prescribed due to cost.

In research published in Neurology, Eva L. Feldman, MD, PhD Professor of Neurology Brian Callaghan, M.D., M.S., worked with a team to examine medication cost trends for five common neurologic conditions.  To do so, they analyzed the annual out-of-pocket and total medication costs for over 500,000 individuals with epilepsy, multiple sclerosis, Parkinson’s disease, peripheral neuropathy, and dementia/Alzheimer’s disease from 2012 to 2021. They found the following:

  • Out-of-pocket costs for multiple sclerosis medications rose annually by an average of 217%.
  • Brand-name epilepsy medications had much higher out-of-pocket costs than generics.
  • Introducing generic versions of various drugs significantly decreased patient out-of-pocket costs over time. 

“These results underscore the cost-saving benefits of choosing generic medications for individuals with neurologic conditions,” explains Dr. Callaghan.  “They also emphasize the need for policy solutions like out-of-pocket cost caps to help make life-saving medications affordable to all who need them.”

Additional authors: Chun Chieh Lin, Ph.D., of University of Michigan,  Amanda Gusovsky, Ph.D., M.P.H. (first author), Kevin Kerber, M.D., and James Burke, M.D., of The Ohio State University, and Evan Reynolds, Ph.D., of Michigan State University.

Paper cited: Gusovsky AV, Lin CC, Kerber K, Reynolds EL, Callaghan BC, Burke JF. Costs Are Still on the Rise for Commonly Prescribed Branded Neurologic Medications. Neurology. 2024 Nov 26;103(10):e210029. doi: 10.1212/WNL.0000000000210029. Epub 2024 Oct 30. PMID: 39475685.

In This Story

Brian C. Callaghan, MD, MS

Brian C Callaghan, MD, MS

Professor

Featured News & Stories

london bridge
Research News

Michigan Alzheimer’s Disease Research Center at AAIC 2026

Michigan Alzheimer’s Disease Research Center at AAIC 2026
stress granules by the Moon Lab
Department News

Explore the Department of Human Genetics Annual Newsletter

We are pleased to share our annual newsletter, featuring departmental milestones from October 2024 through March 2026.
woman looking at screen in office clinical area
Health Lab

How AI is helping emergency physicians learn from their patients

How the “Tell Me What Happens Next” initiative is being used by the Department of Emergency Medicine’s new Division of Clinical Informatics using artificial intelligence.
baby with hearing aid on ear looking from side view with blue pacifier in mouth
Health Lab

Research may help better predict outcomes in kids with congenital cytomegalovirus

Two new studies may help researchers and clinicians better understand congenital cytomegalovirus (CMV), the most common infectious cause of birth defects and a leading cause of non-genetic hearing loss in children.
cigeratte boxes one open and one closed that says vape graphic
Health Lab

A link between e-cigarettes and oral cancer

Answering questions on e-cigerattes and oral cancer based on a new concering study that finds a link, with Marisa Buchakjian, M.D., Ph.D., surgical oncology and microvascular surgeon at Michigan Medicine.
A 3X9 grid of formal individual portraits
Department News

Celebrating the Anesthesiology Residency Class of 2026

The University of Michigan Medical School Department of Anesthesiology celebrated the graduation of 27 residents on June 20, 2026.