Biological Chemistry Research

A biochemistry researcher examines a specimen in the lab

Asking and Answering Fundamental Questions

We explore biological phenomena at the molecular and mechanistic levels to make discoveries about life and health.

Understanding the Foundations of Life

Scientists in the Department of Biological Chemistry integrate many technologies and approaches to study the molecular processes that are the foundation for life and health. Research projects can be grouped into the four broad areas of Biochemical Signaling, Macromolecular Structure & Mechanism, Protein Processing & Folding and Regulation of Gene Expression.

Close ties and cross-appointments with the Life Sciences Institute, the Center for RNA Biomedicine, the Michigan Neuroscience Institute, the Chemical Biology Program, and the LSA departments of Biology, Biophysics, and Chemistry place Biological Chemistry at the center of the University of Michigan's strong biochemical community. 

Our interdisciplinary research into the molecular mechanisms of life offers a wide variety of investigative opportunities to students, fellows, and scientific collaborators.

Research Areas

man using pipette in laboratory

Biochemical Signaling

Probe how cells respond to changes in their environment.

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Macromolecular Structure & Mechanism

Focus in on how biological macromolecules function at the molecular and atomic level.

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Protein Processing & Folding

Understanding the folding, translocation, and processing of proteins is integral to modern molecular and cell biology.

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Regulation of Gene Expression

Use and develop groundbreaking research techniques to uncover the mechanisms that govern gene expression.

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Biological Chemistry News & Stories

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headshot of Patrick O'Brien
Department News

Patrick O'Brien, PhD, featured in ASBMB Today

UM Biological Chemistry professor Patrick O'Brien is interviewed by ASBMB Today.
Computer illustration of the CRISPR complex on DNA
Health Lab

CRISPR acts as commander-in-chief for backup defenses in bacteria

A new study uncovers a previously underrecognized feature of the type I CRISPR-Cas system in the bacteria Neisseria: the presence of additional embedded innate immunity genes.
headshot of Carmen Castillo
Department News

Congratulations to Carmen Castillo, PhD

U-M Biological Chemistry PhD student Carmen Castillo of the Koutmos lab defends her doctoral dissertation.
cells floating green black background strings many floating in backdrop
Health Lab

Scientists discover that bacteria use an understudied polymer found in all life to protect cell functions during stress

New study discovers that polyphosphate, a molecule that exists in all lifeforms but has to date been hard to study, could be a fundamental element worth exploring, say Michigan Medicine researchers.
headshot of Adrian Palumbo
Department News

Adrian Palumbo chosen for a position in the Pharmacological Sciences Training Program

U-M Biological Chemistry PhD student Adrian Palumbo has been awarded a position in the Pharmacological Sciences Training Program.
headshot of John Larson
Department News

John Larson chosen for a position in the Genetics Training Program

U-M Biological Chemistry PhD student John Larson has been awarded a position in the Genetics Training Program.