Education & Outreach | M-BRISC
Resources for Researchers
Articles & Resources
2025 Conner Lecture - Stacey Rosen, MD, FAHA
Please see below for the link to Dr. Stacey E. Rosen’s Lewis A. Conner Presidential Lecture from the American Heart Association’s Scientific Sessions.
Dr. Rosen, President of the American Heart Association, discussed the evolution of women’s cardiovascular health research over the decades and urged clinicians and scientists to continually ask “How does sex matter?” in every study and practice. Her address emphasized inclusion, precision care, and advocacy to close persistent gaps in outcomes.
"Quality control and analytic best practices for testing genetic models of sex differences in large populations"
Journal Summary:
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are becoming increasingly important for understanding the mechanisms driving these differences. To this end, we provide a guide outlining the current best practices for testing various models of sex-dependent genetic effects in complex traits and disease conditions, noting that this is an evolving field. Insights from sex-aware analyses will not only teach us about the biology of complex traits but also aid in achieving the goals of precision medicine and health equity for all.
The NIH ORWH is offering free e-learning courses on Sex as a Biological Variable.
The NIH Policy on Sex as a Biological Variable (SABV) articulates NIH’s expectation that sex, as a biological variable, will be factored into research designs, analyses, and reporting in vertebrate animal and human studies. ORWH's e-learning courses give users a thorough and up-to-date understanding of sex and gender influences on health and disease and NIH requirements on factoring sex as a biological variable into research designs. Visit the ORWH E-Learning page to register. Completion of the free courses will give users the knowledge they need to design and conduct research or interpret evidence for clinical practice.
NIH ORWH | Sex & Gender
"Sex/gender influence health and disease, and considering these factors in research informs the development of prevention strategies and treatment interventions for both women and men."
- ORWH
The missing sex
For most of its history, biomedical research and clinical testing has neglected over half of the world’s population. Finally, researchers and funders are starting to recognize the importance of sex differences.
Citation:
Seydel, C. The missing sex. Nat Biotechnol (2021). https://doi.org/10.1038/s41587-021-00844-4
Published: 23 February 2021
Research in Circulation Go Red issue focuses on sex differences
The latest Circulation journal highlights a major research emphasis on sex differences in cardiovascular care and outcomes. The special focus issue, a collaboration with Go Red for Women® , garnered a record 100-plus manuscripts for consideration. Topics include gender-based differences among resuscitated cardiac arrest patients and recurrent coronary heart disease after myocardial infarction.
American Journal of Preventive Cardiology
Title: Identification of Female-Specific Risk Enhancers throughout the Lifespan of Women to Improve Cardiovascular Disease Prevention
Authors: Petal Elder, Garima Sharma, Martha Gulati, Erin D. Michos
The Trans-NIH Strategic Plan for Women's Health Research
Title: ADVANCING SCIENCE FOR THE HEALTH OF WOMEN The Trans-NIH Strategic Plan for Women's Health Research
Source: National Institutes of Health - Office of Research on Women's Health
Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity
Citation: Singer K, Maley N, Mergian T, DelProposto J, Cho KW, Zamarron BF, Martinez-Santibanez G, Geletka L, Muir L, Wachowiak P, Demirjian C, Lumeng CN. The Journal of biological chemistry. 2015; 290(21):13250-62. PubMed [journal]PMID: 25869128 PMCID: PMC4505578
Sex Differences in Management and Outcomes for ACS Patients
Title: Sex Differences in Management and Outcomes for ACS Patients
Source: American College of Cardiology - CardioSource Plus for Institutions
Nature Reviews: Nephrology
Baylis, C. (2009). Sexual dimorphism in the aging kidney: Differences in the nitric oxide system. Nature Reviews Nephrology, 5(7), 384-396. doi:10.1038/nrneph.2009.90
Sex Differences in the Characteristics of Patients Receiving ICD Therapy for the Primary Prevention of Sudden Cardiac Death
PowerPoint Slides: Sex Differences in the Characteristics of Patients Receiving ICD Therapy for the Primary Prevention of Sudden Cardiac Death
Source: American College of Cardiology - CardioSource Plus for Institutions
