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Publications | Fort Lab
Publications
2025
- Induction of a Müller Glial Cell-Specific Protective Pathway Safeguards the Retina From Diabetes-Induced Damage.
Lin CH, Wu MR, Tanasa B, Prakhar P, Deng B, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S.
Diabetes. 2025 Jan 1;74(1):96-107. doi: 10.2337/db24-0199.
PMID: 39446557 - Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation.
Sluzala ZB, Shan Y, Elghazi L, Cárdenas EL, Hamati A, Garner AL, Fort PE.
Cells. 2024 Dec 4;13(23):2000. doi: 10.3390/cells13232000.
PMID: 39682748 - Report of the 2023 Mary Tyler Moore Vision Initiative Workshop.
Levine SR, Markel DS, Myers MG, Barunas R, Sun JK, Chang DS, Maguire MG, Vujosevic S, Fort PE, Atkinson M, Baschiera F, Gates C, Hunt JM, King GL, Kretzler M, Lai P, Lewis D, Luhmann UFO, McLeod S, Oxenreiter C, Unsworth S, Chambers W, Aiello LP, Ehrlich J, German CL, Tadayoni R, Wolf RM, Silva P, Carlson E, Gott B, Oxenreiter M, Sexton N, Das A, Gardner TW.
Transl Vis Sci Technol. 2025 Jul 1;14(7):11. doi: 10.1167/tvst.14.7.11.
PMID: 40679331 - Key Role of Phosphorylation in Small Heat Shock Protein Regulation via Oligomeric Disaggregation and Functional Activation.
Sluzala ZB, Hamati A, Fort PE.
Cells. 2025 Jan 17;14(2):127. doi: 10.3390/cells14020127.
PMID: 39851555 Free PMC article. Review.
- Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation.
Sluzala ZB, Shan Y, Elghazi L, Cárdenas EL, Hamati A, Garner AL, Fort PE.
Cells. 2024 Dec 4;13(23):2000. doi: 10.3390/cells13232000.
PMID: 39682748 - HSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation.
Besirli CG, Nath M, Yao J, Pawar M, Myers AM, Zacks D, Fort PE.
Neurol Int. 2024 Aug 26;16(5):905-917. doi: 10.3390/neurolint16050068.
PMID: 39311341
- Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy.
Liu H, Ghosh S, Vaidya T, Bammidi S, Huang C, Shang P, Nair AP, Chowdhury O, Stepicheva NA, Strizhakova A, Hose S, Mitrousis N, Gadde SG, Mb T, Strassburger P, Widmer G, Lad EM, Fort PE, Sahel JA, Zigler JS Jr, Sethu S, Westenskow PD, Proia AD, Sodhi A, Ghosh A, Feenstra D, Sinha D.
JCI Insight. 2023 Jun 22;8(12):e168945. doi: 10.1172/jci.insight.168945.
PMID: 37345657
- Frontiers in diabetic retinal disease.
Torm MEW, Dorweiler TF, Fickweiler W, Levine SR, Fort PE, Sun JK, Gardner TW.
J Diabetes Complications. 2023 Feb;37(2):108386. doi: 10.1016/j.jdiacomp.2022.108386. Epub 2022 Dec 21.
PMID: 36608490 - Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
Liu H, Stepicheva NA, Ghosh S, Shang P, Chowdhury O, Daley RA, Yazdankhah M, Gupta U, Hose SL, Valapala M, Fitting CS, Strizhakova A, Shan Y, Feenstra D, Sahel JA, Jayagopal A, Handa JT, Zigler JS Jr, Fort PE, Sodhi A, Sinha D.
Nat Commun. 2022 Oct 13;13(1):6045. doi: 10.1038/s41467-022-33773-0.
PMID: 36229454 - αA-Crystallin Mediated Neuroprotection in the Retinal Neurons Is Independent of Protein Kinase B.
Nath M, Fort PE.
Front Neurosci. 2022 May 20;16:912757. doi: 10.3389/fnins.2022.912757. eCollection 2022.
PMID: 35669493 - mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice.
Fort PE, Losiewicz MK, Elghazi L, Kong D, Cras-Méneur C, Fingar DC, Kimball SR, Rajala RVS, Smith AJ, Ali RR, Abcouwer SF, Gardner TW.
J Biol Chem. 2022 Jun;298(6):101944. doi: 10.1016/j.jbc.2022.101944. Epub 2022 Apr 18.
PMID: 35447116 - Evidence for Paracrine Protective Role of Exogenous αA-Crystallin in Retinal Ganglion Cells.
Nath M, Sluzala ZB, Phadte AS, Shan Y, Myers AM, Fort PE.
eNeuro. 2022 Mar 4;9(2):ENEURO.0045-22.2022. doi: 10.1523/ENEURO.0045-22.2022. Print 2022 Mar-Apr.
PMID: 35168949
- Loss of αA or αB-Crystallin Accelerates Photoreceptor Cell Death in a Mouse Model of P23H Autosomal Dominant Retinitis Pigmentosa.
Wang T, Yao J, Jia L, Fort PE, Zacks DN.
Int J Mol Sci. 2021 Dec 22;23(1):70. doi: 10.3390/ijms23010070.
PMID: 35008496 - Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy.
Fort PE, Rajendiran TM, Soni T, Byun J, Shan Y, Looker HC, Nelson RG, Kretzler M, Michailidis G, Roger JE, Gardner TW, Abcouwer SF, Pennathur S, Afshinnia F.
JCI Insight. 2021 Oct 8;6(19):e152109. doi: 10.1172/jci.insight.152109.
PMID: 34437304 - Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases.
Phadte AS, Sluzala ZB, Fort PE.
Antioxidants (Basel). 2021 Jun 23;10(7):1001. doi: 10.3390/antiox10071001.
PMID: 34201535 - HspB4/αA-Crystallin Modulates Neuroinflammation in the Retina via the Stress-Specific Inflammatory Pathways.
Nath M, Shan Y, Myers AM, Fort PE.
J Clin Med. 2021 May 28;10(11):2384. doi: 10.3390/jcm10112384.
PMID: 34071438 - Insulin-like growth factor-2 regulates basal retinal insulin receptor activity.
Zolov SN, Imai H, Losiewicz MK, Singh RSJ, Fort PE, Gardner TW.
J Biol Chem. 2021 Jan-Jun;296:100712. doi: 10.1016/j.jbc.2021.100712. Epub 2021 Apr 26.
PMID: 33915127 - The innate immune system in diabetic retinopathy.
Pan WW, Lin F, Fort PE.
Prog Retin Eye Res. 2021 Sep;84:100940. doi: 10.1016/j.preteyeres.2021.100940. Epub 2021 Jan 8.
PMID: 33429059
- mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Losiewicz MK, Elghazi L, Fingar DC, Rajala RVS, Lentz SI, Fort PE, Abcouwer SF, Gardner TW.
Exp Eye Res. 2020 Aug;197:108131. doi: 10.1016/j.exer.2020.108131. Epub 2020 Jul 2.
PMID: 32622801
- Eid S, Sas KM, Abcouwer SF, Feldman EL, Gardner TW, Pennathur S, and Fort PE. New Insights into the Mechanisms of Diabetic Complications: Role of Lipids and Lipid Metabolism. Diabetologia 2019 Sep;62(9):1539-1549. doi: 10.1007/s00125-019-4959-1. PMID: 31346658; PMCID: PMC6679814
- YoshitakeS, MurakamiT, Suzuma K, YoshitakeT, Uji A, Morooka S, Dodo Y, Fujimoto M, ShanY, Fort PE, Ito S, TsujikawaA, YoshimuraN. Anti-fumarase Antibody Promotes the Dropout of Photoreceptor Inner and Outer Segments in Diabetic Macular Oedema. Diabetologia. 2018 Nov 28. doi: 10.1007/s00125-018-4773-1. PMID: 30488085
- Miller DJ and Fort PE. Heat Shock Proteins Regulatory Role in Neurodevelopment. Frontiers Neuroscience. 2018 Nov 12; 12:821. doi: 10.3389/fnins.2018.00821. PMID: 30483047
- Brignol TN, Fort PE, Ventura DF, Tadayoni R, Rendon A. Cataract development associated with long-term glucocorticoid therapy in Duchenne muscular dystrophy patients. J AAPOS. 2018 Sep 26. pii: S1091-8531(18)30522-6. PMID: 30266609
- Ruebsam A, Parikh S and Fort PE. Role of Inflammation in Diabetic Retinopathy. Int J Mol Sci. 2018 Mar 22;19(4). doi: 10.3390/ijms19040942. PMID: 29565290
- Nahomi RB, Sampathkumar S, Myers AM, Elghazi L, Smith DG, Tang J, Lee CA, Kern TS, Nagaraj RH and Fort PE. The absence of indoleamine 2,3-dioxygenase inhibits retinal capillary degeneration in diabetic mice.Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2042-2053. doi: 10.1167/iovs.17-22702 PMID: 29677366
- Ruebsam A, Dulle JE, Myers AM, Sakrikar D, Green KM, Kahn NW, Schey K and Fort PE. A specific phosphorylation regulates the protective role of alphaA-crystallin in diabetes. JCI Insight. 2018;3(4):e97919. doi:10.1172/jci.insight.97919. PMID: 29467334
- Abràmoff M, Fort PE, Han I, Sohn E, and Gardner TW. Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease. Invest Ophthalmol Vis Sci, 2018 Jan 1;59(1):519-527. doi: 10.1167/iovs.17-21873. PMID: 29372250
- Ruebsam A, Dulle JE, Garnai SJ, Pawar HS, Fort PE. A Triple Mutation of BetaB2-Crystallin is Necessary to Develop Cataract and Glaucoma. J Clin Exp Ophthalmol.2017, Vol 8(5) : 690.
- BetaB2-crystallin mutations associated with cataract and glaucoma leads to mitochondrial alterations in lens epithelial cells and retinal neurons. Dulle JE, Rübsam A, Garnai SJ, Pawar HS, Fort PE. Exp Eye Res. 2017 Feb;155:85-90. doi: 10.1016/j.exer.2017.01.005. Epub 2017 Jan 26. Review.
- Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt. Kong D, Gong L, Arnold E, Shanmugam S, Fort PE, Gardner TW, Abcouwer SF. Exp Eye Res. 2016 Oct;151:82-95. doi: 10.1016/j.exer.2016.08.002. Epub 2016 Aug 7.
- Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Khan M, Walters LL, Li Q, Thomas DG, Miller JM, Zhang Q, Sciallis AP, Liu Y, Dlouhy BJ, Fort PE, Archer SM, Demirci H, Dou Y, Rao RC. Lab Invest. 2015 Nov;95(11):1278-90. doi: 10.1038/labinvest.2015.104. Epub 2015 Aug 17.
- Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis. Gardner TW, Abcouwer SF, Losiewicz MK, Fort PE. Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E546-56. doi: 10.1152/ajpendo.00180.2015.
- Crystallins and neuroinflammation: The glial side of the story. Dulle JE, Fort PE. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):278-86. doi: 10.1016/j.bbagen.2015.05.023. Epub 2015 Jun 3.
- Current knowledge on diabetic retinopathy from human donor tissues. Eisma JH, Dulle JE, Fort PE. World J Diabetes. 2015 Mar 15;6(2):312-20. doi: 10.4239/wjd.v6.i2.312. Review.
- Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. Dennis MD, Kimball SR, Fort PE, Jefferson LS. J Biol Chem. 2015 Feb 6;290(6):3865-74. doi: 10.1074/jbc.M114.623058. Epub 2014 Dec 29.
- Fort PE, Sahel JA, Rendon A, Tadayoni R. Lack of Dystrophin protein Dp71 results in progressive cataract formation due to loss of fiber cell organization. Molecular Vision2014;20:1480-1490
- Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW. mTORC1-independent reduction of retinal protein synthesis in diabetes. Diabetes 2014 Sep;63(9):3077-90. doi: 10.2337/db14-0235. Epub 2014 Apr 16.
- Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH. Pro-inflammatory cytokines downregulate Hsp27, cause apoptosis of human retinal capillary endothelial cells. BBA - Molecular Basis of Disease, Biochim Biophys Acta 2014 Feb;1842(2):164-74.
- Cia D, Simonutti M, Fort PE, Doly M, Rendon A. Slight alteration of the electroretinogram in mice lacking dystrophin Dp71. Ophthalmic Res 2014 Mar 22;51(4):196-203.
- Heise EA, Marozas LM, Grafton SA, Green KM, Kirwin SJ, Fort PE. Strain-independent increases of crystallin proteins in the retina of type 1 diabetic rats. PLoS One 2013; 8(12):e82520.Fort PE, Losiewicz MK, Reiter CEN, Singh RSJ, Nakamura M, Abcouwer SF, Barber AJ, Gardner TW. Selective roles of hyperglycemia, hypoinsulinemia in diabetes induced retinal cell death: Evidence for retinal insulin resistance. PLoS One 2011;6:e26498.
- Losiewicz MK, Fort PE. Diabetes impairs the neuroprotective properties of retinal alpha-crystallins. Invest Ophthalmol Vis Sci 2011;52:5034-42.
- Fort PE, Lampi KJ. New focus on alpha crystallins in neurodegenerative diseases. Exp Eye Res 2011;92:98-103. Epub 2010 Nov 27. Review.
- Fort PE, Freeman WM, Losiewicz MK, Singh RS, Gardner TW. The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins, reversal by systemic, periocular insulin. Mol Cell Proteomics 2009;8:767-79. Epub 2008 Dec 1.
- Sundstrom JM, Sundstrom CJ, Sundstrom SA, Fort PE, Gardner TW, Antonetti DA. Phosphorylation site mapping of endogenous proteins: A combined MS, bioinformatics approach. J Proteome Res 2009;8:798-807.
- Fort PE, Sene A, Pannicke T, Roux MJ, Forster V, Mornet D, Nudel U, Yaffe D, Reichenbach A, Sahel JA, Rendon A. Kir4.1, AQP4 associate with Dp71-, utrophin-DAPs complexes in specific, defined microdomains of Müller retinal glial cell membrane. Glia 2008;56:597-610.
- Reiter CE, Wu X, Sandirasegarane L, Nakamura M, Gilbert KA, Singh RS, Fort PE, Antonetti DA, Gardner TW. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic, local insulin. Diabetes 2006;55:1148-56.
- Fort P, Estrada FJ, Bordais A, Mornet D, Sahel JA, Picaud S, Rosas Vargas H, Coral-Vázquez RM, Rendon A. The sarcoglycan-sarcospan complex localization in mouse retina is independent from dystrophins. Neurosci Research 2005;53:25-33.
- Bordais A, Bolaños-Jimenez F, Fort P, Varela C, Sahel JA, Picaud S, Rendon A. Molecular cloning, protein expression of Duchenne Muscular Dystrophy gene products in porcine retina. Neuromuscular disorders 2005;15:476-87.
- Dalloz C, Sarig R, Fort P, Yaffe D, Bordais A, Pannicke T, Grosche J, Mornet D, Reichenbach A, Sahel J, Nudel U, Rendon A. Targeted inactivation of dystrohin gene product Dp71: phenotypic impact in mouse retina. Hum Mol Genet 2003;12:1543-54.
Book Chapters
- Fort PE, Rajala RV, Imai H, Gardner TW. Insulin signaling in normal, diabetic conditions. In: Ari S, ed. Signal Transduction: Pathways, Mechanisms, Diseases, Berlin, Germany:Springer, 2009, pp. 101-118.
- Imai H, Singh RSJ, Fort PE, Gardner TW. Neuroprotection in diabetic retinopathy. In: Gandorfer A, ed. Pharmacology, Vitreoretinal Surgery, Basel, Switzerland:Karger, 2009, pp. 44:56-68.
- Fort PE, Singh RS, Losiewicz MK, Gardner TW. Insulin receptor-based signaling in the retina. In: Fliesler SJ, Kisselev O, eds. Signal Transduction in the Retina, Boca Raton:CRC Press, 2007, pp 221-235.
