Jobst Pre-Clinical Research Group
The Jobst Pre-Clinical Research Group offers consultations on best practices for industry standards related to internal and external device trials.
Expertise is available within the multi-disciplinary faculty laboratory members including principal investigators in comparative medicine, vascular surgery, interventional radiology, and pathology.
Contact
Please email us with any questions and submit a consultation request form to learn more about working with the Jobst Pre-Clinical Research Group.
Request a consultation with the Jobst Pre-Clinical Research Group
Our Work
The Jobst Pre-Clinical Research Group has a long and rich history of studying drugs and devices suitable for treatment of the vasculature. The Greenfield IVC filter, the most widely implanted filter worldwide, was created by Dr. Greenfield and evaluated in the laboratory. Various thrombectomy devices, such as the Trellis catheter, underwent initial testing at the research laboratories. Various novel anticoagulants and non-anticoagulant therapies to treat thrombosis have been assessed, including P - and E - selectin antagonists, Galectin – 3 antagonist, vWF aptamer, PAI-1 inhibitors, plasminogen activators and direct oral anticoagulants. The REBOA device for control of arterial hemorrhage underwent initial development in the laboratory.
Funding sources to the Jobst Pre-Clinical Research group include the National Institutes of Health, the Department of Defense, and multiple former and current industry partners including: GlycoMimetics, Medtronic, InterVene, Surmodics, Boston Scientific, and Penumbra. The laboratory boasts state of the art endovascular equipment, ultrasound equipment, and 2,640 square feet of laboratory space for molecular, histologic and tissue culture analysis. Services offered include the following: consulting, animal model development, histologic analysis, pharmacokinetic studies, pre-clinical small and large animal treatment trials.
We collaborate with the Michigan Medicine Cardiovascular Research Network and the Department of Surgery Center for Basic and Translational Science.
- Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. Obi AT, Sharma SB, Elfline MA, Luke CE, Dowling AR, Cai Q, Kimball AS, Hollinstat M, Stanger L, Moore BB, Jaffer FA, Henke PK. Sci Rep. 2023 Feb 24;13(1):3253. doi: 10.1038/s41598-023-30149-2. PMID: 36828892 Free PMC article.
- Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design. La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. Nat Commun. 2023 Apr 26;14(1):2177. doi: 10.1038/s41467-023-37709-0. PMID: 37100783 Free PMC article.
- The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor. Stanger L, Yamaguchi A, Yalavarthi P, Lambert S, Gilmore D, Rickenberg A, Luke C, Kumar K, Obi AT, White A, Bergh N, Dahlöf B, Holinstat M. Blood. 2023 Nov 2;142(18):1556-1569. doi: 10.1182/blood.2023020622. PMID: 37624927
- Yang P, Yang S, Durham L, Lester PA, Myers DD Jr. Efficacy evaluation of two extended-release bupivacaine using a porcine model of incisional pain. J Am Assoc Lab Anim Sci. 2024 Jul 1;63(4):422-427. doi: 10.30802/AALAS-JAALAS-23-000106. Epub 2024 Mar 20. PMID: 38508691
- Rodent Inferior Vena Cava Venoplasty Balloon Model. Moreno O, Luke CE, Clay A, Durham L, Rocco S, Kumar K, Parchment N, Babcock DE, Myers DD, Wakefield TW, Henke P, Obi AT. J Vis Exp. 2024 May 24;(207). doi: 10.3791/66820. PMID: 38856208
- Moreno O, Clay A, Luke C, Kumar K, Rocco S, Parchment N, Myers D, Wakefield T, Henke P, Obi A. Abstract 2092: Ultrasound and Histology Protocol for Characterization of Venous Stents Effect In Deep Veins In Vivo. May 2024 ATVB 44 (Suppl. 1). Doi.10.116/atvb.44.suppl_1.2092
- Assi IZ, Lynch SR, Ricker BD, Ranjane SV, Williams DM, Wakefield TW, Obi AT, and Figueroa CA (2024), A comparative study of altered hemodynamics in iliac vein compression syndrome. Front. Bioeng. Biotechnol. 12:1302063. doi: 10.3389/fbioe.2024.1302063
- Masuda E, Ozsvath K, Monahan D, Wakefield TW. ”Appropriate Use Criteria for Management of Lower Extremity Chronic Venous Disease” Handbook of Venous and Lymphatic Disorders. Guidelines of the American Venous Forum, 6th edition. Eds M Dalsing, P Gloviczki, F Lurie, G Moneta, C Shortell, T Wakefield. p. 805-815, CRC Press New York, NY. 2024
- Obi AT, Henke PK, Wakefield TW. “Pathogenesis and new insights into acute and chronic venous thrombosis:.” Handbook of Venous and Lymphatic Disorders 5th Edition. Eds P Gloviczki, M Dalsing, M Gloviczki, F Lurie, G Moneta, C Shortell, T Wakefield p. 45-59, CRC Press New York, NY. 2024
- Gloviczki ML, Dalsing MC, Lurie F, Moneta GL, Shortell CK, Wakefield TW, Gloviczki P. “Summary of guidelines of venous and lymphatic disorders of the American Venous Forum.” Handbook of Venous and Lymphatic Disorders 5th Edition. Eds P Gloviczki, M Dalsing, M Gloviczki, F Lurie, G Moneta, C Shortell, T Wakefield p. 817-839, CRC Press New York, NY. 2024
Learn about the history of the Conrad Jobst Vascular Research Laboratories.
our team
Dave Gordon
Dean Emeritus, School of Health Professions and Studies, The University of Michigan-Flint
Director of Faculty Programs, Office for Health Equity and Inclusion
Peter Henke, MD, FACS, FAHA
Professor of Surgery
Section Head of Vascular Surgery
Co-Director Frankel Cardiovascular Center
Minhaj S Khaja, MD, MBA, FSIR, FSVM
Clinical Professor of Radiology
Clinical Professor of Cardiac Surgery
Program Associate of IR/DR Residency
Department of Radiology
Medical School
Daniel D Myers Jr
Professor of Surgery
Professor of Laboratory Animal Medicine and Veterinarian
Laboratory Animal Medicine
Medical School
William M Sherk, MD
Clinical Director, Radiology
Section Head, Radiology
Program Director, Integrated IR/DR Residency
Medical School
David M Williams, MD, FSIR
Professor Emeritus of Internal Medicine-Cardiology, Medical School
Patrick Lester, RPh, DVM, MS, BCPS, DACLAM
Andrea T Obi, MD
Associate Professor of Surgery and Ambulatory Care Clinical Chief
Medical School
Thomas W Wakefield
Medical School
