The Gill Lab
The Gill lab is interested in elucidating the pathophysiology of chronic rhinosinusitis (CRS), an upper airway inflammatory disorder, with the goal of uncovering novel therapeutic targets that facilitate improved disease outcomes.
Explore the Gill Lab
Three inter-related areas of focus for the Gill lab include: 1) elucidating the complex relationship between epithelial tissue damage, TREM2+ macrophage recruitment, and T cell exhaustion in CRS; 2) understanding tight junction changes driving epithelial barrier impairment in high wildfire and non-wildfire particulate matter exposures; and 3) developing novel, topical therapeutics strategies for improving CRS outcomes. To accomplish these goals, the Gill lab combines epidemiological work with outcomes-based and basic science research. Single cell RNA sequencing, spatial transcriptomics, and proteomic techniques are used to analyze patient tissue samples; these findings, in turn, inspire mechanism-based in vitro and in vivo experiments in the lab, as we work toward therapeutic applications.
Amarbir S. Gill, MD
Assistant Professor of Otolaryngology
Rhinology and Skull Base Surgery
