Heft Neal Lab Publications

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Key Publications

Explore significant publications from the Heft Neal Lab
  1. Heft Neal ME, Bakst RL, Chai RL.Considerations and Cautions in Postoperative HPV Circulating Tumor DNA Kinetics.JAMA Otolaryngol Head Neck Surg. 2025 May 14. doi: 10.1001/jamaoto.2025.1612. Online ahead of print. PMID: 40367056 No abstract available.
  2. Haring CT, Windon MJ, Heft Neal ME, Brenner JC.Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead.Clin Cancer Res. 2025 Jun 24. doi: 10.1158/1078-0432.CCR-25-1488. Online ahead of print. PMID: 40552930
  3. Smith JD, Gensterblum-Miller E, Forner DWA, Yalamanchi P, Buchakjian MR, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, Mclean SA, Mierzwa ML, Shah J, Swiecicki PL, Worden FP, Prince MEP, Spector ME, Brenner JC, Heft Neal ME.Tumor Hypoxia and CD8+ T-Cell Infiltration in Patients With Advanced Laryngeal Cancer.Otolaryngol Head Neck Surg. 2025 May 5. doi: 10.1002/ohn.1291. Online ahead of print. PMID: 40323140
  4. Smith JD, Darr OAF, Haring CT, Rosko AJ, Spector ME, Heft-Neal ME. Nerve dissection technique for excision of parotid tumors: Outcomes controlling for tumor size and location.Am J Otolaryngol. 2025 Jan-Feb;46(1):104582. doi: 10.1016/j.amjoto.2024.104582. Epub 2024 Dec 21. PMID: 39731964
  5. Gensterblum-Miller E, Bhangale A, Majid DA, Pienkowski VM, Rydzanicz M, Janiszewska J, Kostrzewska-Poczekaj M, Chang C, Brummel C, Michmerhuizen NL, Wang J, Sandford E, Tewari M, Wierzbicka M, Birkeland AC, McHugh JB, Spector ME, Giefing M, Jarmuz-Szymczak M, Heft Neal ME, Brenner JC.Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma.Oral Oncol. 2024 Dec;159:107108. doi: 10.1016/j.oraloncology.2024.107108. Epub 2024 Nov 15. PMID: 39549430 Free PMC article.
  6. Heft Neal ME, Smith JD, Lyden TH, Chanowski EJP, Morrison RJ, Contrera K, Sridharan S, Chinn SB, Chepeha DB, Spector ME.Oral cavity obliteration is a novel predictor of functional outcomes after glossectomy reconstruction. Oral Oncol. 2024 Dec;159:107058. doi: 10.1016/j.oraloncology.2024.107058. Epub 2024 Oct 7. PMID: 39378611
  7. Heft Neal ME, Haring CT, Bellile E, Jaffe CC, Shuman AG, Chinn SB, Stucken CL, Malloy KM, Casper KA, Prince MEP, Chepeha DB, Rosko AJ, Spector ME. Phase II Clinical Trial of Intravenous Levothyroxine to Mitigate Pharyngocutaneous Fistula in Euthyroid Patients Undergoing Salvage Laryngectomy.Clin Cancer Res. 2024 Jul 15;30(14):2910-2916. doi: 10.1158/1078-0432.CCR-24-0782. PMID: 38723280 Clinical Trial.
  8. Heft Neal ME, Walline HM, Haring CT.Circulating Tumor DNA in Human Papillomavirus-Mediated Oropharynx Cancer: Leveraging Early Data to Inform Future Directions.Cancer J. 2023 Jul-Aug 01;29(4):215-219. doi: 10.1097/PPO.0000000000000670. PMID: 37471611 Review.
  9. Dermody SM, Walline H, Bhambhani C, Tewari M, Swiecicki PL, Mierzwa M, Heft Neal ME, Spector ME, Brenner JC.Addressing knowledge gaps in HPV-related oropharyngeal cancer prevention: A call for action.Oral Oncol. 2025 Apr;163:107234. doi: 10.1016/j.oraloncology.2025.107234. Epub 2025 Mar 5. PMID: 40049067 Free PMC article. No abstract available.
  10. Benjamin WJ, Feng AL, Heft Neal M, Bellile E, Casper KA, Malloy KM, Rosko AJ, Stucken CL, Prince ME, Mierzwa ML, Taylor JMG, Eisbruch A, Spector ME, Wolf GT, Swiecicki PL, Worden FP, Chinn SB.Utility of bioselection with neoadjuvant chemotherapy for organ preservation in patients with T4 laryngeal cancer.Oral Oncol. 2024 Sep;156:106917. doi: 10.1016/j.oraloncology.2024.106917. Epub 2024 Jun 28. PMID: 38945011
  11. Smith JD, Heft-Neal ME, Rosko AJ, Chepeha DB, Spector ME.Upfront neck dissection to guide single-modality therapy for early stage supraglottic squamous cell carcinoma.Oral Oncol. 2024 May;152:106803. doi: 10.1016/j.oraloncology.2024.106803. Epub 2024 Apr 12. PMID: 38613849 No abstract available.
  12. Swiecicki PL, Bellile E, Dragovic AF, McHugh J, Udager A, Mierzwa ML, Shah J, Heft-Neal M, Rosko A, Malloy KM, Casper K, Chinn SB, Shuman AG, Stucken C, Chepeha DB, Wolf GT, Bradford CR, Eisbruch A, Prince ME, Worden FP, Spector ME.Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC.Clin Cancer Res. 2024 Jun 3;30(11):2393-2401. doi: 10.1158/1078-0432.CCR-23-3247. PMID: 38517480 Free PMC article. Clinical Trial.
  13. Heft Neal ME, Birkeland AC, Bhangale AD, Zhai J, Kulkarni A, Foltin SK, Jewell BM, Ludwig ML, Pinatti L, Jiang H, McHugh JB, Marentette L, McKean EL, Brenner JC.Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.BMC Cancer. 2021 May 29;21(1):636. doi: 10.1186/s12885-021-08370-x. PMID: 34051734 Free PMC article.
  14. Heft Neal ME, Smith JD, Birkeland AC, Haring CT, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, Mclean SA, Rosko AJ, Mierzwa ML, Shah J, Schonewolf C, Swiecicki PL, Worden FP, Wolf GT, Bradford CR, Prince MEP, Brenner JC, Spector ME.Tumor-Infiltrating Lymphocytes in Patients With Advanced Laryngeal Cancer Undergoing Bioselection.Otolaryngol Head Neck Surg. 2022 Mar;166(3):498-505. doi: 10.1177/01945998211013765. Epub 2021 May 25. PMID: 34030495 Free PMC article.
  15. Heft Neal ME, Gensterblum-Miller E, Bhangale AD, Kulkarni A, Zhai J, Smith J, Brummel C, Foltin SK, Thomas D, Jiang H, McHugh JB, Brenner JC. Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma.Oral Oncol. 2021 Jun;117:105270. doi: 10.1016/j.oraloncology.2021.105270. Epub 2021 Apr 4. PMID: 33827033 Free PMC article.
  16. Heft Neal ME, Bhangale AD, Birkeland AC, McHugh JB, Shuman AG, Rosko AJ, Swiecicki PL, Spector ME, Brenner JC.Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma.Cancers (Basel). 2020 Oct 22;12(11):3081. doi: 10.3390/cancers12113081. PMID: 33105726
  17. Cao Y, Haring CT, Brummel C, Bhambhani C, Aryal M, Lee C, Heft Neal M, Bhangale A, Gu W, Casper K, Malloy K, Sun Y, Shuman A, Prince ME, Spector ME, Chinn S, Shah J, Schonewolf C, McHugh JB, Mills RE, Tewari M, Worden FP, Swiecicki PL, Mierzwa M, Brenner JC.Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma.Clin Cancer Res. 2022 Jan 15;28(2):350-359. doi: 10.1158/1078-0432.CCR-21-2338. Epub 2021 Oct 26. PMID: 34702772 Free PMC article. Clinical Trial.
  18. Haring CT, Bhambhani C, Brummel C, Jewell B, Bellile E, Heft Neal ME, Sandford E, Spengler RM, Bhangale A, Spector ME, McHugh J, Prince ME, Mierzwa M, Worden FP, Tewari M, Swiecicki PL, Brenner JC.Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma. Oncotarget. 2021 Jun 22;12(13):1214-1229. doi: 10.18632/oncotarget.27992. eCollection 2021 Jun 22. PMID: 34194620 Free PMC article.