Publications | Seeley Lab
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Key Publications
  1. Ryan, K., Tremaroli, V., Clemmensen, C. et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509, 183–188 (2014). https://doi.org/10.1038/nature13135
  2. Ryan, K., Li, B., Grayson, B. et al. A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med 17, 623–626 (2011). https://doi.org/10.1038/nm.2349
  3. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science. 2006 May 12;312(5775):927-30. doi: 10.1126/science.1124147. PMID: 16690869.
  4. Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun;124(6):2456-63. doi: 10.1172/JCI72434. Epub 2014 Apr 24. PMID: 24762441; PMCID: PMC4038572.
  5. Wortman MD, Clegg DJ, D'Alessio D, Woods SC, Seeley RJ. C75 inhibits food intake by increasing CNS glucose metabolism. Nat Med. 2003 May;9(5):483-5. doi: 10.1038/nm0503-483. PMID: 12724740.
  6. Grayson BE, Schneider KM, Woods SC, Seeley RJ. Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med. 2013 Aug 21;5(199):199ra112. doi: 10.1126/scitranslmed.3006505. PMID: 23966301; PMCID: PMC3939702.
  7. Stefater MA, Pérez-Tilve D, Chambers AP, Wilson-Pérez HE, Sandoval DA, Berger J, Toure M, Tschöp M, Woods SC, Seeley RJ. Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology. 2010 Jun;138(7):2426-36, 2436.e1-3. doi: 10.1053/j.gastro.2010.02.059. Epub 2010 Mar 10. PMID: 20226189; PMCID: PMC2883635.
  8. Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ. GM-CSF action in the CNS decreases food intake and body weight. J Clin Invest. 2005 Nov;115(11):3035-44. doi: 10.1172/JCI25681. PMID: 16276414; PMCID: PMC1265876.
  9. Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, Seeley RJ, Woods SC. The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci. 2002 Oct 15;22(20):9048-52. doi: 10.1523/JNEUROSCI.22-20-09048.2002. PMID: 12388611; PMCID: PMC6757684.
  10. Jae Hoon Shin, Nadejda Bozadjieva-Kramer, Yikai Shao, Sally Lyons-Abbott, Alan C. Rupp, Darleen A. Sandoval, Randy J. Seeley, The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function, Cell Metabolism, Volume 34, Issue 11, 2022, Pages 1765-1778.e6, ISSN 1550-4131, https://doi.org/10.1016/j.cmet.2022.09.024.
  11. Klein, S., Seeley, R.J. Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes. Nat Metab 5, 912–914 (2023). https://doi.org/10.1038/s42255-023-00823-w
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