Seeley Lab Publications

Bozadjieva-Kramer N, McMahon G, Li Z, Wean J, Shin JH, Myronovych A, O'Rourke RW, MacDougald OA, Seeley RJ. Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss. Diabetes. 2026 Apr 1:db250466. doi: 10.2337/db25-0466. Epub ahead of print. PMID: 41920187.

Blok NB, Evers SS, Lewis AG, Toure MH, Bozadjieva-Kramer N, Seeley RJ, Myronovych A. Towards a better mouse model of vertical sleeve gastrectomy. Surg Obes Relat Dis. 2025 Nov;21(11):1198-1209. doi: 10.1016/j.soard.2025.06.017. Epub 2025 Jul 30. PMID: 40841215.

Wean J, Kowalsky AH, Laker R, Will S, Drucker DJ, Rhodes CJ, Seeley RJ. Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss. Mol Metab. 2025 May;95:102074. doi: 10.1016/j.molmet.2024.102074. Epub 2024 Nov 26. PMID: 39612941; PMCID: PMC11946504.

Wean J, Baranwal S, Miller N, Shin JH, O'Rourke RW, Burant CF, Seeley RJ, Rothberg AE, Bozadjieva-Kramer N. Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss. Diabetes Metab. 2024 Sep;50(5):101570. doi: 10.1016/j.diabet.2024.101570. Epub 2024 Aug 10. PMID: 39134173; PMCID: PMC12330221.

Bozadjieva-Kramer N, Shin JH, Li Z, Rupp AC, Miller N, Kernodle S, Lanthier N, Henry P, Seshadri N, Myronovych A, MacDougald OA, O'Rourke RW, Kohli R, Burant CF, Rothberg AE, Seeley RJ. Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance. JCI Insight. 2024 Apr 8;9(7):e174164. doi: 10.1172/jci.insight.174164. PMID: 38587078; PMCID: PMC11128213.

Klein, S., Seeley, R.J. Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes. Nat Metab 5, 912–914 (2023). https://doi.org/10.1038/s42255-023-00823-w

Jae Hoon Shin, Nadejda Bozadjieva-Kramer, Yikai Shao, Sally Lyons-Abbott, Alan C. Rupp, Darleen A. Sandoval, Randy J. Seeley, The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function, Cell Metabolism, Volume 34, Issue 11, 2022, Pages 1765-1778.e6, ISSN 1550-4131, https://doi.org/10.1016/j.cmet.2022.09.024.

Seeley, R.J., Rhodes, C.J. Who knew? PPARs may act in the brain too. Nat Metab 4, 965–966 (2022). https://doi.org/10.1038/s42255-022-00625-6

Bozadjieva-Kramer N, Shin JH, Shao Y, Gutierrez-Aguilar R, Li Z, Heppner KM, Chiang S, Vargo SG, Granger K, Sandoval DA, MacDougald OA, Seeley RJ. Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. Nat Commun. 2021 Aug 6;12(1):4768. doi: 10.1038/s41467-021-24914-y. PMID: 34362888; PMCID: PMC8346483.

Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun;124(6):2456-63. doi: 10.1172/JCI72434. Epub 2014 Apr 24. PMID: 24762441; PMCID: PMC4038572.

Ryan, K., Tremaroli, V., Clemmensen, C. et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509, 183–188 (2014). https://doi.org/10.1038/nature13135

Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science. 2006 May 12;312(5775):927-30. doi: 10.1126/science.1124147. PMID: 16690869.