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ECLS Lab Publications

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Key Publications & Abstracts

Artificial Lungs and Related Physiology

Fernando UP, Thompson AJ, Pokey J, Cheriyan H, Toomasian J, Kaesler A, Schlanstien P, Arens J, Hirschl RB, Bull JL, Bartlett RH. A membrane lung design based on circular blood flow paths. ASAIO J 2017; 63(5):637-643.
Trahanas JM, Alghanem F, Ceballos-Muriel C, Hoffman HR, Xu A, Deatrick KB, Cornell M, Rojas-Pena A, Bartlett RH, Hirschl RB. Development of a model of pediatric lung failure pathophysiology. ASAIO J 2017; 63(2):216-222.
Alghanem F, Bryner BS, Jahangir EM, Fernando UP, Trahanas JM, Hoffman HR, Bartlett RH, Rojas-Pena A, Hirschl RB. Pediatric artificial lung: a low-resistance pumpless artificial lung alleviates an acute lamb model of increased right ventricle afterload. ASAIO J 2017; 63(2):223-228.
Trahanas JM, Kolobow MA, Hardy MA, Berra L, Zapol WM, Bartlett RH. “Treating lungs” – The scientific contributions of Dr. Theodor Kolobow. ASAIO J 2016; 62(2):203-210.
Alghanem F, Davis RP, Bryner BS, Hoffman HR, Trahanas J, Cornell MS, Rojas-Pena A, Bartlett RH, Hirschl RB. The implantable pediatric artificial lung: Interim report on the development of an end-stage lung failure model. ASAIO J. 2015 Jul-Aug; 61(4): 453-458.
Camboni D, Rojas A, Sassalos P, Spurlock D, Koch KL, Menchak S, Singleton J, Boothman E, Haft JW, Bartlett RH, Cook KE. Long-term animal model of venovenous extracorporeal membrane oxygenation with atrial septal defect as a bridge to lung transplantation. ASAIO J. 2013 Nov-Dec; 59(6): 558-563.
Camboni D, Akay B, Pohlmann JR, Koch KL, Haft JW, Bartlett RH, Cook KE. Veno-venous extracorporeal membrane oxygenation with interatrial shunting: A novel approach to lung transplantation for patients in right ventricular failure. J Thorac Cardiovasc Surg. 2011 Feb; 141(2): 537-42, 542.e1.

Blood Surface Interaction

VanZalen JJ; Stein MV; Kauffman R; Hill JE; Strode, William J; Peláez-Palacio D; Lautner G; Meyerhoff ME; Bartlett RH; Lautner-Csorba O; Rojas-Peña A. 234: Nitric Oxide Surface Anticoagulation for Venovenous ECMO in an Ovine Model. 35^th ELSO Annual Conference, Sept 28 – Oct 1, 2024. Detroit, MI ASAIO Journal. 70(Supplement 4):71, September-October 2024.
Chakraborty T, Caudill M, Kauffman R, Stein M, Hill J, Burde A, Lautner G, Bartlett RH, Rojas-Peña A, Lautner-Csorba O. Bivalirudin as a Direct Thrombin Inhibitor in a Polymer Surface Coating. Oral Presentation, ASAIO 2024 Annual Conference, Baltimore, MD, 2024, ASAIO Journal.70, (May 2024, Supplement 3): 30. DOI: 10.1097/01.mat.0001024016.86815.cf
Toomasian CJ, Aiello SR, Drumright BL, Majro TC, Bartlett RH, Toomsian JM. The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction. Perfusion, [Epub ahead of print].
Brisbois EJ, Major TC, Goudie MJ, Bartlett RH, Meyerhoff ME, Handa H. Improved hemocompatibility of silicone rubber extracorporeal tubing via solvent swelling-impregnation of S-nitro-N-acetylpenicillamine (SNAP) and evaluation in rabbit thrombogenicity model. Acta Biomater 2016; 37:111-119.
Wo Y, Brisbois EJ, Bartlett RH, Meyerhoff ME. Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO). Biomater Sci 2016; 4(8):1161-1183.
Brisbois EJ, Major TC, Goudie MJ, Meyerhoff ME, Bartlett RH, Handa H. Attenuation of thrombosis and bacterial infection using dual function nitric oxide releasing central venous catheters in a 9day rabbit model. Acta Biomater 2016, 44:304-312.
Yu J, Brisbois E, Handa H, Annich G, Meyerhoff M, Bartlett R, Major T. The immobilization of a direct thrombin inhibitor to a polyurethane as a nonthrombogenic surface coating for extracorporeal circulation. J Mater Chem B Mater Biol Med 2016; 4(13):2264-2272.
Ren H, Colletta A, Koley D, Wu J, Xi C, Major TC, Bartlett RH, Meyerhoff ME. Thromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release. Bioelectrochemistry. 2015 Aug; 104: 10-16. PMC4480771.
Brisbois EJ, Davis RP, Jones AM, Major TC, Bartlett RH, Meyerhoff ME, Handa H. Reduction in thrombosis and bacterial adhesion with 7 day implantation of -nitroso--acetylpenicillamine (SNAP)-doped elast-eon E2As catheters in sheep. J Mater Chem B Mater Biol Med. 2015 Feb 28; 3(8): 1639-1645. PMC4326019.
Brisbois EJ, Bayliss J, Wu J, et al. Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model. Acta Biomater. 2014 PMC4160367.

Extracorporeal Circulation

Alexander WD, Urrea K, Chakrabortty V, Nakashima T, Bartlett RH, Drake D, Rojas-Peña A. 189: Utilization of ECMO Technologies in Normothermic Ex-vivo Heart Perfusion Prolongation. 35^th ELSO Annual Conference, Sept 28 – Oct 1, 2024. Detroit, MI. ASAIO Journal. 70(Supplement 4):22, September-October 2024.
Alexander W, Urrea K, Chakrabortty V, Nakashima T, Bartlett R, Drake D, Rojas-Peña A: 48 Hour Normothermic Ex-vivo Heart Perfusion with Modified Plasma Supplementation: An Early Series, Abstract, Oral Presentation, ASAIO 2024 Annual Conference, Baltimore, MD, 2024, ASAIO Journal.70, (May 2024, Supplement 3): 78. DOI: 10.1097/01.mat.0001024016.86815.cf
Alexander W, Urrea K, Chakrabortty V, Nakashima T, Bartlett R, Rojas-Peña A, Drake D: Determination of Ideal Coronary Flow Rates for Prolonged Normothermic Ex-Vivo Heart Perfusion, Abstract, Oral Presentation, ASAIO 2024 Annual Meeting, Baltimore, MD, 2024, ASAIO Journal.70, (May 2024, Supplement 3): 77. DOI: 10.1097/01.mat.0001024016.86815.cf
Jacob M, Zhang A, Blum S, Chambers A, Seilo G, Pelaez-Palacio D, Blaine J, Vandenberg Z, Mychaliska G, Potkay J, Rojas-Peña A: Custom 3D Printed Cannulas for Extracorporeal Life Support in Preterm Neonates, Abstract, Oral Presentation, ASAIO 2024 Annual Meeting, Baltimore, MD, 2024, ASAIO Journal.70, (May 2024. Supplement 3): 44. DOI: 10.1097/01.mat.0001024016.86815.cf
Zhang A, Haimowitz B, Tappeta R, Dababna Q, Doan M, Bartlett R, Rojas-Peña A, Potkay J: An ECMO Sweep Gas Controller with Closed-Loop Feedback, Abstract, Oral Presentation, ASAIO 2024 Annual Meeting, Baltimore, MD, 2024, ASAIO Transactions.70, (May 2024, Supplement 3): 40. DOI: 10.1097/01.mat.0001024016.86815.cf
Bartlett RH. Physiology of gas exchange during ECMO for respiratory failure. J Intensive Care Med 2017; 32(4):243-248.
Bartlett RH. Esperanza: the first neonatal ECMO patient. ASAIO J 2017; 63(6):832-843.
Bartlett RH, Deatrick KB. Current and future status of extracorporeal life support for respiratory failure in adults. Curr Opin Crit Care 2016; 22(1):80-85.
Werner NL, Coughln M, Cooley E, Haft JW, Hirschl RB, Bartlett RH, Mychaliska GB. The University of Michigan experience with veno-venoarterial hybrid mode of extracorporeal membrane oxygenation. ASAIO J 2016; 62(5):578-583.
Gray BW, Haft JW, Hirsch JC, Annich GM, Hirschl RB, Bartlett RH. Extracorporeal life support: Experience with 2000 patients. ASAIO J. 2015; 61(6): 2-7. PMC4280306.
Bartlett RH. Extracorporeal life support: Gibbon fulfilled. J Am Coll Surg. 2014;218(3):317-327 PMID: 24559949.
Gray BW, El-Sabbagh A, Zakem SJ, Koch KL, Rojas-Pena A, Owens GE, Bocks ML, Rabah R, Bartlett RH, Mychaliska GB. Development of an artificial placenta V: 70h veno-venous extracorporeal life support after ventilatory failure in premature lambs. J Pediatr Surg. 2013 Jan; 48(1): 145-153.
Bryner BS, Smith C, Cooley E, Bartlett RH, Mychaliska GB. Extracorporeal life support for pancreatitis-induced acute respiratory distress syndrome. Ann Surg. 2012 Jul 20.
Spurlock DJ, Koch K, Mazur DE, Fracz EM, Bartlett RH, Haft JW. Preliminary in vivo testing of a novel pump for short-term extracorporeal life support. Ann Thorac Surg. 2012 Jan; 93(1): 141-146. PMC3244559.
Spurlock DJ, Toomasian JM, Romano MA, Cooley E, Bartlett RH, Haft JW. A simple technique to prevent limb ischemia during veno-arterial ECMO using the femoral artery: The posterior tibial approach. Perfusion. 2012 Mar; 27(2): 141-145.

Organ Preservation & Transplantation

Johnson, Matthew D.; Zimmerman, Karen G.; Nakashima, Takahiro; Urrea, Kristopher A.; Rojas-Pena, Alvaro; Bartlett, Robert H.; Drake, Daniel H.. Artificial Intelligence-Assisted Strain Echocardiography in an Ex Vivo Heart. ASAIO Journal 69(12):p e523-e525, December 2023. | DOI: 10.1097/MAT.0000000000001994
Gok E, Alghanem F, Moon R, Guy E, Rojas-Pena A, Bartlett RH, Ozer K. Development of an ex-situ limb perfusion system for a rodent model. ASAIO J 2018; [Epub ahead of print].
Rojas-Pena A, Bartlett RH. Ex-situ organ preservation: the temperature paradigm. Transplantation 2018; 103(4):554-556.
Church JT, Alghanem F, Deatrick KB, Trahanas JM, Phillips JP, Song AH, Perkins EM, Bartlett RH, Rojas-Pena A, Bocks ML, Owens GE. Normothermic ex-vivo heart perfusion: effects of live animal blood and plasma cross-circulation. ASAIO J 2017; 63(6):766-773.
Werner NL, Alghanem F, Rakestraw SL, Sarver DC, Nicely B, Pietroski RE, Lange P. Rudick SM, Mendias CL, Rojas-Pena A, Magee JC, Bartlett RH, Ozer K. Ex situ perfusion of human limb allografts for 24 hours. Transplantation 2017; 101(3):e68-e74.
Ozer K, Rojas-Pena A, Mendias CL, Bryner BS, Toomasian C, Bartlett RH. The effect of ex situ perfusion in a swine limb vascularized composite tissue allograft on survival up to 24 hours. J Hand Surg Am 2016; 41(1):3-12.
Trahanas JM, Witer LJ, Alghanem F, Bryner BS, Iyangar A, Hirschl JR, Hoenerhoff MJ, Potkay JA, Bartlett RH, Rojas-Pena A, Owens GE, Bocks ML. Achieving 12 hour normothermic ex situ heart perfusion: an experience of 40 porcine hearts. ASAIO J 2016; 62(4):470-476.
Demos DS, Iyengar A, Bryner BS, Gray BW, Hoffman HR, Cornell MS, Wilkinson JE, Mazur DE, Bartlett RH, Punch JD, Rojas-Pena A. Successful porcine renal transplantation after 60 minutes of donor warm ischemia: Extracorporeal perfusion and thrombolytics. ASAIO J. 2015 Jul-Aug; 61(4): 474-479. PMC4486602.
Ozer K, Rojas-Pena A, Mendias CL, Bryner B, Toomasian C, Bartlett RH. Ex situ limb perfusion system to extend vascularized composite tissue allograft survival in swine. Transplantation. 2015 Apr 29 [Epub ahead of publication].
Rojas-Pena A, Sall LE, Gravel MT, Cooley EG, Pelletier SJ, Bartlett RH. Donation After Circulatory Determination of Death: The University of Michigan Experience With Extracorporeal Support. Transplantation. 2014 PMID: 24825520.
Teman NR, Demos DS, Bryner BS, et al. In Vivo testing of a novel blood pump for short-term extracorporeal life support. Ann Thorac Surg. 2014;98(1):97-102 PMC4097385.

Clinical Critical Care

Trahanas JM, Lynch WR, Bartlett RH. Extracorporeal support for chronic obstructive pulmonary disease: a bright future. J Intensive Care Med 2017; 32(7):411-420.
Spinelli E, Davis RP, Ren X, Sheth PS, Tooley TR, Iyengar A, Sowell B, Owens GE, Bocks ML, Jacobs TL, Yang LJ, Stacey WC, Bartlett RH, Rojas-Pena A, Neumar RW. Thrombolytic-enhanced extracorporeal cardiopulmonary resuscitation after prolonged cardiac arrest. Crit Care Med 2016; 44(2):e58-e69.
Bartlett RH. Clinical research in acute fatal illness: lessons from extracorporeal membrane oxygenation. J Intensive Care Med 2016; 31(7):456-465.
Spinelli E, Bartlett RH. Anemia and transfusion in critical care: Physiology and management. J Intensive Care Med. 2015 Feb 18.
Dechert RE, Park PK, Bartlett RH. Evaluation of the oxygenation index in adult respiratory failure. J Trauma Acute Care Surg. 2014;76(2):469-473 PMID: 24458052.
Maclaren G, Butt W, Peek G, Lynch WR, Bartlett RH. Mistaking complications of critical illness for those of critical care. Crit Care Med. 2014;42(2):e173-4 PMID: 24434475.

Artificial Placenta

Harvey SL, Fallon BP, McLeod JS, Matusko N, Rabah R, Arnold MA, Rojas-Pena A, Bartlett RH, Mychaliska GB. Hepatic Function in Premature Lambs Supported by the Artificial Placenta and Total Parenteral Nutrition. ASAIO J. 2022 Jul 1;68(7):949-955.
Church JT, Perkins EM, Coughlin MA, McLeod JS, Boxx K, Bentley JK, Hershenson MB, Rabah R, Bartlett RH, Mychaliska GB. Perfluorocarbons prevent lung injury and promote development during artificial placenta support in extremely premature lambs. Neonatology 2018, 113(4):313-321.
El-Sabbagh AM, Gray BW, Shaffer AW, Bryner BS, Church JT, Mcleod JS, Zakem S, Perkins EM, Shellhaas RA, Barks JDE, Rojas-Pena A, Bartlett RH, Mychaliska GB. Cerebral oxygenation of premature lambs supported by an artificial placenta. ASAIO J 2017; 64(4):552-556.
Church JT, Kim AC, Erickson KM, Rana A. Drongowski R, Hirschl RB, Bartlett RH, Mychaliska GB. Pushing the boundaries of ECLS: outcomes in <34 week EGA neonates. J Pediatr Surg 2017; 52(11):1810-1815.
Bryner B, Gray B, Perkins E, Davis R, Hoffman H, Barks J, Owens G, Bocks M, Rojas-Pena A, Hirschl R, Bartlett R, Mychaliska G. An extracorporeal artificial placenta supports extremely premature lambs for 1 week. J Pediatr Surg. 2015 Jan; 50(1): 44-49. PMCID: PMC4487774.
Gray BW, El-Sabbagh A, Zakem SJ, et al. Development of an artificial placenta V: 70h veno-venous extracorporeal life support after ventilatory failure in premature lambs. JPediatr Surg. 2013;48(1):145-153.
Gray BW, El-Sabbagh A, Rojas-Pena A, et al. Development of an artificial placenta IV: 24 hour venovenous extracorporeal life support in premature lambs. ASAIO J. 2012;58(2):148-154.
Gray BW, El-Sabbagh A, Rojas A, Koch KL, Bartlett RH, Mychaliska GB. Development of an artificial placenta: 24 hour venovenous extracorporeal life support in premature lambs. ASAIO J. 2011;57(2):107.

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