Chronic Pain & Fatigue Research Center
The Chronic Pain and Fatigue Research Center (CPFRC) at the University of Michigan is a pioneering interdisciplinary center dedicated to advancing our understanding of chronic pain and fatigue disorders. Since our founding in 1998, we’ve been leaders in identifying how distinct conditions—such as fibromyalgia, interstitial cystitis, osteoarthritis, low back pain, and post-deployment syndromes often share common biological mechanisms.
Explore the CPFRC
Our Focus
Our research zeroes in on how the central nervous system contributes to these complex conditions, with particular interest in nociplastic pain and the interplay between peripheral and central factors that drive the pain experience. Utilizing state-of-the-art approaches, we study pain from every angle—including:
- Advanced neuroimaging (structural, functional, and neurochemical)
- Multisensory quantitative sensory testing
- Genetics and precision health
- Patient-reported outcomes
- Actigraphy and ecological momentary assessment
- Immune and autonomic nervous system measurement
We are committed to discovering effective therapies, evaluating both innovative pharmacological approaches (such as cannabis and psychedelics) and non-pharmacological treatments (such as cognitive-behavioral therapy, exercise, and acupuncture).
We do not offer patient care, give out medical advice, or physician recommendations or referrals. We are a research facility only. You may find a list of useful resources for patients here.
Make a Gift
The CPFRC invites anyone to support our research efforts.
Contribute the amount of your choice through the University of Michigan’s online giving portal.
Collaboration & Impact
Although rooted in the Department of Anesthesiology at the University of Michigan Medical School, CPFRC thrives on multidisciplinary collaboration—working with departments, schools, and global partners.
We also take pride in supporting those affected by chronic pain and fatigue, their loved ones, and the clinical and research communities. We offer innovative resources like:
- PainGuide: A free, web-based education and self-management tool for chronic pain.
- PASCGuide: Our latest patient-centric platform supporting individuals with long COVID (PASC).
Leadership & Training
CPFRC is proud to serve as the national hub for the NIH HEAL National Pain K12 Career Development Program. This award recognizes our leadership in mentoring and training the next generation of pain scientists and clinicians.
Explore Resources
PainGuide
An education and self-management resource supporting a patient-centric model of chronic pain care
PASCGuide
A resource supporting a patient-centric model for those living with long COVID, also known as post-acute sequelae of COVID-19 (PASC).
COPCScreener
The COPCS is an assessment tool that helps in the identification of different COPCs that may co-exist within a given individual.
Conquer Lupus
A place where Warriors and their communities can find resources for living with lupus.
A Better Me with Sickle Cell Disease
A place where Warriors and their communities can find resources for living with sickle cell disease.
Featured News
Studying Period Pain
Who’s at risk for painful periods?
U-M study to evaluate cannabis coaching program for chronic low back pain
Contact Us
Lobby M, Suite 3100
Ann Arbor, MI
