Clinical Trials | CPFRC
Recruiting Research Studies
The studies below are currently seeking participants.
Please find additional studies at UMHealthResearch.org.
This research is studying the pain-related effects of active components from cannabis (a.k.a. marijuana) in small numbers of people to learn about its safety and its effect on the body at certain doses among people with knee osteoarthritis. The study drugs are a combination of capsules and solution forms to be taken orally and are experimental for knee osteoarthritis but approved by the FDA for other indications.
The purpose of this study is to better understand how active components from cannabis can reduce knee osteoarthritis pain or other related symptoms.
The STEPS or “Stratifying Eye Pain Study” is a research study investigating the different types of chronic eye pain with the goal of understanding your experience when it comes to living with eye pain and the biological mechanisms causing eye pain. With the information learned from this study, doctors will be better equipped to personalize care and improve pain relief for people living with this often invisible and frustrating condition.
This research is studying whether changing an individual’s behaviors may have an impact as a treatment for migraine headaches. The purpose of the study is to test whether different types of brief Zoom-based classes can help adults with chronic migraine learn effective strategies for reducing migraine headache pain, disability and other problems that can come with headache (such as poor sleep, depression, or anxiety).
This research is studying whether a brief Zoom-based behavioral intervention can help Veterans with Chronic Low Back Pain (CLBP) learn effective strategies for reducing pain and other problems that can come with CLBP.
The goal of this study is to test whether a brief Zoom-based behavioral treatment can help adults with lupus learn effective strategies for reducing pain, disability and other problems that can come with lupus (such as depression and anxiety)
This research is studying how and why endometriosis, an often under-researched condition, causes pain and how the condition changes over time. The purpose of this study is to better understand whether several blood, imaging, and sensory tests help predict change in symptoms and response to usual treatments over one year. With this knowledge, future treatments can potentially be personalized to each patient’s specific biological profile.
The purpose of this study is to better understand how hormone suppression with Relugolix Combination-Therapy (CT) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis associated pelvic pain. Relugolix CT (a combination tablet consisting of relugolix 40mg, estradiol 1mg, norethindrone acetate 0.5mg) has been approved by the Food and Drug Administration (FDA) for the treatment of moderate-severe pain associated with endometriosis.
For more information, please contact the team at [email protected] or 734-998-0396.
The CORK or “Cannabidiol for postoperative Opioid Reduction in primary total Knee arthroplasty Study” is investigating how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The purpose of the study is to help understand whether CBD may be a useful medication before and/or after surgery.
For more information, please contact the team at [email protected] or 734-232-0320.
The purpose of this study is to better understand brain activity and thinking skills in people with Fibromyalgia, and how other symptoms such as pain, fatigue, depression, and anxiety may affect daily cognitive functioning.
Using a method called an Electroencephalogram (EEG), researchers in this study hope to identify brain regions that may be important as potential areas for targeted treatments in the future. Individuals with FM are thought to have brain characteristics that are different from pain-free individuals which may influence their thinking skills as well as their response to pain.
For more information, please contact Thomas Prince @ [email protected] or 734-998-7023
People living with Rheumatoid Arthritis commonly report persisting pain, which on average is 30% more intense than that of the general population. Previous research has found that this ongoing pain may in part be caused by problems in the way the brain processes pain signals. This is called pain centralization. This study will identify factors that lead to the development of pain centralization, so that in future studies we can learn more about how to prevent the development of this kind of chronic pain in Rheumatoid Arthritis.
For more information, please contact Courtney Cole @ [email protected] or 734-998-7021
This large clinical trial will test morning bright light versus sleep timing stabilization versus treatment as usual to reveal the key active elements of morning bright light treatment for fibromyalgia, the social determinants of health on treatment and explore the mechanism of action in the treatment of chronic pain.
The overall objective of this project is to determine whether treating low back pain patients based on their unique “pain phenotype” will lead to better outcomes. We will also evaluate if there are different and/or overlapping mechanisms driving the perception of pain. The goal is to address the questions of who responds best to what treatment and how these treatments work.
MIVetsCan: The Can-Coach Study is a research study and educational program that offers a free Fitbit and four coaching sessions to help you effectively use cannabis products for managing pain symptoms.
Note: You'll be responsible for purchasing the cannabis products you decide to use. By participating, you’ll discuss how to more effectively use cannabis products available in the state market for pain management. This includes understanding different methods of ingestion, tracking your symptoms, what you are taking, how much you take, and the potential negative side effects.
