Frankel Lab Publications

1. Bonilla ME, Radyk MD, Perricone MD, Elhossiny AM, Harold AC, Medina-Cabrera PI, Kadiyala P, Shi J, Frankel TL, Carpenter ES, Green MD, Mitrea C, Lyssiotis CA, Pasca di Magliano M. Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment. JCI Insight. 2024 Aug 13;9(18):e180114. doi: 10.1172/jci.insight.180114.PMID: 39315547
2. Enzler T, Shi J, McGue J, Griffith BD, Sun L, Sahai V, Nathan H, Frankel TL. A Comparison of Spatial and Phenotypic Immune Profiles of Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions. Int J Mol Sci. 2024 Mar 3;25(5):2953. doi: 10.3390/ijms25052953.PMID: 38474199
3. Griffith BD, Lazarus J, McGue J, Krishnan S, D'Angelica MI, Shia J, Dobrosotskaya I, Shi J, Edwards J, Rao A, Frankel TL. Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer. Front Immunol. 2023 Dec 13;14:1289402. doi: 10.3389/fimmu.2023.1289402. eCollection 2023.PMID: 38152402
4. McGue JJ, Edwards JJ, Griffith BD, Frankel TL. Multiplex Fluorescent Immunohistochemistry for Preservation of Tumor Microenvironment Architecture and Spatial Relationship of Cells in Tumor Tissues. Methods Mol Biol. 2023;2660:235-246. doi: 10.1007/978-1-0716-3163-8_16.PMID: 37191801
5. Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL*, Pasca di Magliano M*. Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions. Cancer Discov. 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013.PMID: 37021392 - *co-corresponding authors
6. Griffith BD, Turcotte S, Lazarus J, Lima F, Bell S, Delrosario L, McGue J, Krishnan S, Oneka MD, Nathan H, Smith JJ, D'Angelica MI, Shia J, Di Magliano MP, Rao A, Frankel TL. MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment. Cancers (Basel). 2022 Aug 24;14(17):4092. doi: 10.3390/cancers14174092.PMID: 36077630
7. Qin A, Lima F, Bell S, Kalemkerian GP, Schneider BJ, Ramnath N, Lew M, Krishnan S, Mohammed S, Rao A, Frankel TL. Cellular engagement and interaction in the tumor microenvironment predict non-response to PD-1/PD-L1 inhibitors in metastatic non-small cell lung cancer. Sci Rep. 2022 May 31;12(1):9054. doi: 10.1038/s41598-022-13236-8.PMID: 35641540
8. Krishnan SN, Mohammed S, Frankel TL, Rao A. GaWRDenMap: a quantitative framework to study the local variation in cell-cell interactions in pancreatic disease subtypes. Sci Rep. 2022 Mar 8;12(1):3708. doi: 10.1038/s41598-022-06602-z.PMID: 35260589
9. Frankel TL, Pasca di Magliano M. Immune sensing of microbial metabolites: Action at the tumor. Immunity. 2022 Feb 8;55(2):192-194. doi: 10.1016/j.immuni.2022.01.009.PMID: 35139348
10. Steele NG, Carpenter ES, Kemp SB, Sirihorachai VR, The S, Delrosario L, Lazarus J, Amir ED, Gunchick V, Espinoza C, Bell S, Harris L, Lima F, Irizarry-Negron V, Paglia D, Macchia J, Chu AKY, Schofield H, Wamsteker EJ, Kwon R, Schulman A, Prabhu A, Law R, Sondhi A, Yu J, Patel A, Donahue K, Nathan H, Cho C, Anderson MA, Sahai V, Lyssiotis CA, Zou W, Allen BL, Rao A, Crawford HC*, Bednar F*, Frankel TL*, Pasca di Magliano M*. Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer. Nat Cancer. 2020 Nov;1(11):1097-1112. doi: 10.1038/s43018-020-00121-4. Epub 2020 Oct 26.PMID: 34296197 *co-corresponding authors
11. Carpenter E, Nelson S, Bednar F, Cho C, Nathan H, Sahai V, di Magliano MP, Frankel TL. Immunotherapy for pancreatic ductal adenocarcinoma. J Surg Oncol. 2021 Mar;123(3):751-759. doi: 10.1002/jso.26312.PMID: 33595893
12. Perusina Lanfranca M, Zhang Y, Girgis A, Kasselman S, Lazarus J, Kryczek I, Delrosario L, Rhim A, Koneva L, Sartor M, Sun L, Halbrook C, Nathan H, Shi J, Crawford HC, Pasca di Magliano M, Zou W, Frankel TL. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice. Gastroenterology. 2020 Apr;158(5):1417-1432.e11. doi: 10.1053/j.gastro.2019.12.010. Epub 2019 Dec 14.PMID: 31843590

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