Publications | Hepler Lab

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Find significant publications from the Hepler Lab.

Key Publications

 

  • Hepler C*, Waldeck NJ, Weidemann BJ, Marcheva B, Chen Y-J, Hecker J, Zhu Z, Nozawa R, Mastroni JV, Thorne AK, Reczek CR, Cedernaes J, Ramsey KM, Peek CB, Barish GD, Chandel NS, Bass J* [*co-corresponsing authors]. Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome. Nature Metabolism. 2026. doi: 10.1038/s42255-026-01464-5
  • Dumont KD, Heydari Seradj S, Wang Y, Liu S, Cervenka I, Wu C, Jannig PR, Porsmyr-Palmertz M, Baiges-Gaya G, Huang X, Nihlen C, Dias JM, Skiotyte SS, Præstholm SM, Wilbert D, Leuchtmann AB, Quinn MA, Zhu Z, Hepler C, Lundberg JO, Teixeira AI, Rosenzweig A, Wu J, Ye L, Ruas JL. Sensory-neuron-derived CGRPα; controls white adipocyte differentiation and tissue plasticity. Cell Reports. 2025;44(12). doi: 10.1016/j.celrep.2025.116613
  • Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J: Time-restricted feeding mitigates obesity through adipocyte thermogenesis. Science.378(6617): 276-284, 10/2022. PM36264811 doi: 10.1126/science.abl8007
  • Hepler C, Shan B, Zhang Q, Henry GH, Shao M, Vishvanath L, Ghaben AL, Mobley AB, Strand D, Hon GC, Gupta RK: Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Elife.709/2018. PM30265241 doi: 10.7554/eLife.39636
  • Hepler C, Shao M, Xia JY, Ghaben AL, Pearson MJ, Vishvanath L, Sharma AX, Morley TS, Holland WL, Gupta RK: Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. Elife.607/2017. PM28722653 doi: 10.7554/eLife.27669

Selected Reviews

 

  • Hepler C, Bass J: Circadian mechanisms in adipose tissue bioenergetics and plasticity. Genes Dev.37(11-12): 454-473, 06/2023. PM37364987 doi: 10.1101/gad.350759.123
  • Hepler C, Gupta RK: The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment. Mol Cell Endocrinol.445: 95-108, 04/2017. PM27743993 doi: 10.1016/j.mce.2016.10.011
  • Hepler C, Vishvanath L, Gupta RK: Sorting out adipocyte precursors and their role in physiology and disease. Genes Dev.31(2): 127-140, 01/2017. PM28202540 doi: 10.1101/gad.293704.116

 

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