Singh Lab

Anemia is a very common condition that affects approximately 1 in 3 people around the world. One of the key causes of anemia is bone marrow failure, which is a condition where the body fails to produce enough red blood cells. Genetic defects in ribosomes can lead to bone marrow failure leading to severe anemia requiring chronic red blood cell transfusions or bone marrow transplant.

Our team, along with many collaborators across Michigan Medicine, are working to advance the understanding of the disease process of ribosome disorders, like Diamond Blackfan Anemia Syndrome (DBAS). This disease also leads to an increased risk of cancer and birth defects for unclear reasons. We are using new, sophisticated, unbiased approaches to learn more about the impact of ribosomal dysfunction on normal body function and to develop new treatments for anemia and cancer.