Key Publications
Explore significant publications from the O'Rourke Lab.
- Ky A, McCoy AJ, Flesher CG, Friend NE, Li J, Akinleye K, Patsalis C, Lumeng CN, Putnam AJ, O'Rourke RW. Matrix density regulates adipocyte phenotype. Adipocyte. 2023;12(1):2268261. doi: 10.1080/21623945.2023.2268261. Epub 2023 Oct 10. PMID: 37815174; PMCID: PMC10566443.
- Muir LA, Cho KW, Geletka LM, Baker NA, Flesher CG, Ehlers AP, Kaciroti N, Lindsly S, Ronquist S, Rajapakse I, O'Rourke RW, Lumeng CN. Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters. JCI Insight. 2022;7(3):e146563. doi: 10.1172/jci.insight.146563. PMID: 34990410; PMCID: PMC8855803.
- Strieder-Barboza C, Flesher CG, Geletka LM, Eichler T, Akinleye O, Ky A, Ehlers AP, Lumeng CN, O’Rourke RW. Lumican modulates adipocyte function in obesity-associated type 2 diabetes. Adipocyte, 2022;11(1):665-675. doi: 10.1080/21623945.2022.2154112. PMID: 36457256; PMCID: PMC9728465.
- Porsche CE, DelProposto JB, Geletka L, O'Rourke RW, Lumeng CN. Obesity results in adipose tissue T cell exhaustion. JCI Insight 2021. 6(8):139793. PMID: 33724954 DOI: 10.1172/jci.insight.139793.
- Carruthers NJ, Strieder-Barboza C, Caruso JA, Flesher CG, Baker NA, Kerk SA, Ky A, Ehlers AP, Varban OA, Lyssiotis CA, Lumeng CN, Stemmer PM, O’Rourke RW. The human diabetes-specific visceral adipose tissue proteome in obesity. Sci Rep 2021;11(1):17394. PMID: 34462518 PMCID: PMC8405693 DOI: 10.1038/s41598-021-96995
- Juliar BA, Strieder-Barboza C, Baker NA, Flesher CG, Karmakar M, Varban OA, Lumeng CN, Putnam A, O'Rourke RW. Viscoelastic characterization of diabetic and non-diabetic human adipose tissue. Biorheology, 2020, 57 (1):15-26, Feb 17. PMID: 32083565; DOI: 10.3233/BIR-190234.
- Strieder-Barboza C, Baker NA, Flesher CG, Karmakar M, Patel A, Lumeng CN, O'Rourke RW. Depot-specific adipocyte-extracellular matrix metabolic crosstalk in murine obesity. Adipocyte, 2020, 9(1):89-96. PMID: 32272860; PMCID: PMC7153651; DOI: 10.1080/21623945.2020.1749500.
- Russo L, Muir LA, Geletka L, Delproposto J, Baker NA, Flesher CG, O'Rourke RW, Lumeng CN. Cholesterol 25-Hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes. Mol Met, 2020 Mar 27; 39:100983. PMID: 32229247; PMCID: PMC7267735; DOI: 10.1016/j.molmet.2020.100983
- Youngblood R, DelProposto JB, Baker NA, Flesher CG, Neeley CK, Lumeng CN, Li F, Shea LD, O'Rourke RW. Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin-4. Biotechnol Bioeng 2020, Jul 30, Online ahead of print; PMID: 32729936; DOI: 10.1002/bit.27523
- Wenderott JK, Flesher CG, Baker NA, Neeley CK, Varban OA, Lumeng CN, Muhammad LN, Yeh C, Green PF, O'Rourke RW. Elucidating nanoscale mechanical properties of diabetic and non-diabetic human adipose tissue using atomic force microscopy. Sci Rep 2020, Nov 24;10(1):20423. PMID: 33235234; PMCID: PMC7686328; DOI: 10.1038/s41598-020-77498-w.
- Frydrych LM, Bian G, Fattahi F, Morris S, O'Rourke RW, Lumeng CN, Kunkel SL, Ward PA, Delano MJ. GM-CSF administration improves defects in innate immunity and sepsis survival in obese diabetic mice; J Immunol. 2019; 202(3):931-942; PMID: 30578307. DOI: 10.4049/jimmunol.1800713.
- Flesher CG, Baker NA, Strieder-Barboza C, Polsinelli D, Varban OA, Lumeng CN, O'Rourke RW. A human 3D extracellular matrix-adipocyte culture model for studying matrix-cell metabolic crosstalk. J Vis Exp, 2019 Nov 7;(153). PMID: 31762470; DOI: 10.3791/60486.
- Strieder-Barboza C, Baker NA, Flesher CG, Karmakar M, Neeley CK, Polsinelli D, Dimick, JB, Finks JF, Ghaferi AA, Varban OA, Lumeng CN, O'Rourke RW. Advanced glycation end-products regulate adipocyte-extracellular matrix metabolic crosstalk. Sci Rep, 2019 Dec 24; 9(1):19748. PMID: 31875018; DOI: 10.1038/s41598-019-56242-z.
