Research | Musculoskeletal Study Research
Our Studies
Welcome to the Musculoskeletal Research Lab at the University of Michigan
Current Research:
Our team works at the intersection of clinical research, genetics, and genomics to better understand the mechanisms of shoulder disorders. We lead two major initiatives: CuffGen, which explores the genetic epidemiology of rotator cuff tears, and OAGEN which investigates the genetic susceptibility to glenohumeral osteoarthritis. Together, these projects aim to define how genetics influence disease risk, progression and clinical outcomes.
We use advanced tools such as Illumina microarrays, bulk RNA-sequencing and single-cell RNA-sequencing to discover new biological signals linked to disease and point toward potential targets for therapeutics.
Our lab’s research areas include:
- Clinical research including Clinical Trials: Rotator Cuff Tears (MOON, ROW and ARC)
- Genetic causes of Rotator Cuff Tears (CuffGen)
- Multi-omics investigation of Glenohumeral Osteoarthritis (OAGEN)
Through this work, our lab is dedicated to generating insights that bridge basic science and clinical applications, ultimately advancing musculoskeletal health and patient care.
Clinical Trials
Arthroscopic Rotator Cuff
A randomized controlled trial comparing rehabilitation treatment (physical therapy) to surgery in the treatment of rotator cuff tears.
Multicenter Orthopedic Outcomes Network
The MOON Shoulder Group is a Multi-Center Orthopedic Outcome Network. This group is made up of doctors from around the country, who all work together on research with the hope of giving patients with shoulder problems the best possible care.
Rotator Cuff Outcomes Network
A cohort study assessing best way to diagnose rotator cuff tears and patient characteristics that lead to better recovery from rotator cuff tears with either surgery or physical therapy.
Genetics & Genomics
CuffGEN
The CuffGEN study is an observational cohort based on cases and controls to determine genetic patterns associated with rotator cuff tears.
Multi-omics investigation of Glenohumeral Osteoarthritis (OAGEN)
This study seeks to elucidate the genetic architecture underlying glenohumeral osteoarthritis (GH OA) through a comprehensive multi-omics approach combining genome-wide association study (GWAS) and transcriptomic analyses.
