Research Activities

labcoat

Research Activities

highlighted_in_cancer_discovery

Highlighted in Cancer Discovery 2020;10:345–7.

Regulatory T cell depletion causes compensatory immune suppression and accelerated pancreatic carcinogenesis.
Abstract | PDF
highlighted_in_cancer_discovery

Highlighted in Cancer Discovery 2020;10(6):757.

Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Abstract | PDF
highlighted_in_gut_microbes

Highlighted in Gut Microbes 2020;18:1-3.

A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.
Abstract | PDF
highlighted_in_nature_reviews_nephrology

Highlighted in Nature Reviews Nephrology 2019; ePub ahead of print.

Abnormal oxidative metabolism in a quiet genomic backgorund underlies clear cell papillary renal cell carcinoma.
Abstract | Full Article
highlighted_in_nature_reviews_cancer

Highlighted in Nature Reviews Cancer 2019;19:304.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF
highlighted_in_nature_reviews_immunology

Highlighted in Science Translational Medicine 2019;11:487.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF
highlighted_in_science_translational_medicine

Highlighted in Science Translational Medicine 2019;11:487.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF
highlighted_in_cancer_discovery

Highlighted in Cancer Discovery 2019;9:574

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF
highlighted_in_nature_reviews_gastroenterology_hepatology

Highlighted in Nature Reviews Gastroenterology & Hepatology 2019;16:262

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF
highlighted_in_jbc_special_virtual_issue_on_tumor_metabolism

Highlighted in JBC Special (Virtual) Issue on Tumor Metabolism

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
Abstract | PDF
highlighted_in_cell_metabolism

Highlighted in Cell Metabolism (2017). Apoptotic Regulatory T Cells Retain Suppressive Function Through Adenosine

Oxidative Stress Controls Regulatory T cell Apoptosis and Suppressor Activity and PD-L1-blockade Resistance in Tumor
Abstract | PDF
highlighted_in_cancer_cell_2017._muc-king_with_hif_may_rewire_pyrimidine_biosynthesis_and_curb_gemcitabine_resistance_in_pancreatic_cancer

Highlighted in Cancer Cell (2017). MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Abstract | PDF
singh-lyssiotis

Highlighted in Pancreatic Cancer Action Network (2017). Grantees Collaborate to Understand Treatment Resistance

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Abstract | PDF
Highlighted in Nature (2016). Cancer metabolism: Friendly neighbours feed tumour cells

Highlighted in Nature (2016). Cancer metabolism: Friendly neighbours feed tumour cells 

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information
highlighted_in_science_signaling_2016._pdac_puts_its_neighbors_to_work

Highlighted in Science Signaling (2016). PDAC puts its neighbors to work | Article

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information
highlighted_in_nature_reviews_cancer_2016._feeding_your_friends

Highlighted in Nature Reviews Cancer (2016). Feeding your friends

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information
 
highlighted_in_nature_reviews_gastroenterology_hepatology_2016._pancreatic_cancer-_stromal_crosstalk_supports_tumour_metabolism

Highlighted in Nature Reviews Gastroenterology & Hepatology (2016). Pancreatic cancer: Stromal crosstalk supports tumour metabolism

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information
highlighted_in_cancer_discovery_2016._autophagic_pancreatic_stellate_cells_promote_pancreatic_tumour_growth

Highlighted in Cancer Discovery (2016). Autophagic Pancreatic Stellate Cells Promote Pancreatic Tumour growth

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information
highlighted_by_science_daily._team_finds_new_approach_to_curbing_cancer_growth

Highlighted by Science Daily. Team Finds New Approach to Curbing Cancer Growth

Identification of a Small Molecule Inhibitor of 3-Phosphoglycerate Dehydrogenase to Target Serine Biosynthesis in Cancers
Abstract | PDF
highlighted_in_cancer_discovery._pi3k_promotes_glycolysis_through_release_of_cytoskeletal_aldolase

Highlighted in Cancer Discovery. PI3K Promotes Glycolysis through Release of Cytoskeletal Aldolase

Phosphoinositide 3-Kinase Regulates Glycolysis Through an AKT-independent Mechanism that Mobilizes Aldolase A Release from the Actin Cytoskeleton
Abstract | PDF
Most read paper in Cancer & Metabolism, 2015.

Targeting Glutamine Metabolism Sensitizes Pancreatic Cancer to PARP1-driven Metabolic Catastrophe Induced by ß-lapachone
Abstract
U.S. Patent Number 2015/0126580, filed December 20, 2011 and issued May 7, 2015.

Methods for Diagnosing and Treating Oncogenic Kras-Associated Cancer. 

DePinho R, Cantley LC, Kimmelman A, Ying H, Lyssiotis CA. International Patent Number 14/367,341, filed June 20, 2014.
U.S. Patent Number 2015/0110773, filed May 23, 2013 and issued April 23, 2015.

Targeting the Glutamine to Pyruvate Pathway for Treatment of Oncogenic Kras-Associated Cancer.

Kimmelman AC, Son J, Cantley LC, Lyssiotis CA.